Head and neck sarcomas: the first report addressing the duration of symptoms and diagnostic work up

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Head and neck sarcomas : the first report addressing the duration of symptoms and diagnostic work up. / Aalling, Mathilde; Klug, Tejs Ehlers; Ovesen, Therese.

In: Acta Oto-Laryngologica, Vol. 140, No. 6, 06.2020, p. 521-525.

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@article{d365858fc59a47f782f06800b1f52dc6,
title = "Head and neck sarcomas: the first report addressing the duration of symptoms and diagnostic work up",
abstract = "Background: Head and neck sarcomas are rare and difficult to diagnose and manage. Aim: To describe a population of patients with head and neck sarcomas focusing on the effect of symptom duration and time to diagnosis on mortality and recurrence risk. Materials and methods: Fifty-one patients treated in our department between 1998–2013 were retrospectively included. Patient and tumour characteristics as well as dates of interest were obtained from sarcoma registries, charts and pathology records. The effect of symptom duration and time to diagnosis on mortality and risk of recurrence was tested by multivariate analysis. Results: There was a wide range in symptom duration (1–144 months, median 5) and time for diagnosis (0–234 days, median 14) without significant effect on overall mortality, disease-specific mortality or risk of recurrence. Chondrosarcomas in the larynx dominated among the patients with the longest diagnostic duration. Conclusion and significance: The diagnostic process is challenging and in some cases of extremely long duration without effect on mortality. The symptom duration and time to diagnosis in relation to mortality and risk of recurrence has not previously been described. Early biopsy, better imaging and advanced pathological techniques can hopefully speed up the diagnostic process and reduce morbidity and mortality.",
keywords = "cancer, Head and neck, neoplasm, sarcoma, symptom duration, time to diagnosis, SURGERY, SOFT-TISSUE SARCOMAS, MANAGEMENT, PROGNOSTIC-FACTORS",
author = "Mathilde Aalling and Klug, {Tejs Ehlers} and Therese Ovesen",
year = "2020",
month = jun,
doi = "10.1080/00016489.2020.1733656",
language = "English",
volume = "140",
pages = "521--525",
journal = "Acta Oto-Laryngologica",
issn = "0001-6489",
publisher = "Taylor & Francis ",
number = "6",

}

RIS

TY - JOUR

T1 - Head and neck sarcomas

T2 - the first report addressing the duration of symptoms and diagnostic work up

AU - Aalling, Mathilde

AU - Klug, Tejs Ehlers

AU - Ovesen, Therese

PY - 2020/6

Y1 - 2020/6

N2 - Background: Head and neck sarcomas are rare and difficult to diagnose and manage. Aim: To describe a population of patients with head and neck sarcomas focusing on the effect of symptom duration and time to diagnosis on mortality and recurrence risk. Materials and methods: Fifty-one patients treated in our department between 1998–2013 were retrospectively included. Patient and tumour characteristics as well as dates of interest were obtained from sarcoma registries, charts and pathology records. The effect of symptom duration and time to diagnosis on mortality and risk of recurrence was tested by multivariate analysis. Results: There was a wide range in symptom duration (1–144 months, median 5) and time for diagnosis (0–234 days, median 14) without significant effect on overall mortality, disease-specific mortality or risk of recurrence. Chondrosarcomas in the larynx dominated among the patients with the longest diagnostic duration. Conclusion and significance: The diagnostic process is challenging and in some cases of extremely long duration without effect on mortality. The symptom duration and time to diagnosis in relation to mortality and risk of recurrence has not previously been described. Early biopsy, better imaging and advanced pathological techniques can hopefully speed up the diagnostic process and reduce morbidity and mortality.

AB - Background: Head and neck sarcomas are rare and difficult to diagnose and manage. Aim: To describe a population of patients with head and neck sarcomas focusing on the effect of symptom duration and time to diagnosis on mortality and recurrence risk. Materials and methods: Fifty-one patients treated in our department between 1998–2013 were retrospectively included. Patient and tumour characteristics as well as dates of interest were obtained from sarcoma registries, charts and pathology records. The effect of symptom duration and time to diagnosis on mortality and risk of recurrence was tested by multivariate analysis. Results: There was a wide range in symptom duration (1–144 months, median 5) and time for diagnosis (0–234 days, median 14) without significant effect on overall mortality, disease-specific mortality or risk of recurrence. Chondrosarcomas in the larynx dominated among the patients with the longest diagnostic duration. Conclusion and significance: The diagnostic process is challenging and in some cases of extremely long duration without effect on mortality. The symptom duration and time to diagnosis in relation to mortality and risk of recurrence has not previously been described. Early biopsy, better imaging and advanced pathological techniques can hopefully speed up the diagnostic process and reduce morbidity and mortality.

KW - cancer

KW - Head and neck

KW - neoplasm

KW - sarcoma

KW - symptom duration

KW - time to diagnosis

KW - SURGERY

KW - SOFT-TISSUE SARCOMAS

KW - MANAGEMENT

KW - PROGNOSTIC-FACTORS

UR - http://www.scopus.com/inward/record.url?scp=85081905124&partnerID=8YFLogxK

U2 - 10.1080/00016489.2020.1733656

DO - 10.1080/00016489.2020.1733656

M3 - Journal article

C2 - 32186247

AN - SCOPUS:85081905124

VL - 140

SP - 521

EP - 525

JO - Acta Oto-Laryngologica

JF - Acta Oto-Laryngologica

SN - 0001-6489

IS - 6

ER -