TY - JOUR
T1 - HbA1c-defined prediabetes and progression to type 2 diabetes in Denmark
T2 - A population-based study based on routine clinical care laboratory data
AU - Nicolaisen, Sia Kromann
AU - Pedersen, Lars
AU - Witte, Daniel R.
AU - Sørensen, Henrik Toft
AU - Thomsen, Reimar Wernich
N1 - Funding Information:
The study was supported by the Department of Clinical Epidemiology’s Research Foundation at Aarhus University. The funding source had no role in the collection, analysis, or interpretation of the data, nor in the study design or writing of the manuscript.
Publisher Copyright:
© 2023
PY - 2023/9
Y1 - 2023/9
N2 - Aims: To estimate the prevalence, incidence, mortality, and risk of progression to type 2 diabetes for individuals with HbA1c-defined prediabetes based on Danish nationwide population-based laboratory databases. Methods: We included all HbA1c measurements from general practice and hospitals during 2012 to 2018. We estimated the cumulative incidence of having at least one HbA1c measurement. The prevalence and incidence rates of prediabetes (HbA1c 42–47 mmol/mol) were examined in the adult Danish population. The 5-year cumulative incidence of progression to type 2 diabetes was estimated with death as competing event. Results: Among 4,979,590 adult Danes, 70.8% (95% CI 70.8–70.9) had at least one HbA1c measurement during 2012 to 2018. The prevalence of prediabetes was 7.1% (95% CI 7.1–7.1) in 2018. The incidence rate was 14.2 (95% CI 14.1–14.3) per 1,000 person-years, with median age 66.9 years (IQR 56.7–75.7) and median HbA1c 43 mmol/mol (IQR 42–44) at prediabetes diagnosis. Within five years, 17.5% (95% CI 17.3–17.7) died and the 5-year cumulative incidence of type 2 diabetes was 21.3% (95% CI 21.1–21.5). Conclusions: Out of 100 Danish adults, 1.4 develop prediabetes each year and they can be identified at an early stage in laboratory databases. Within five years, one in five individuals with prediabetes progresses to diabetes and one in six dies.
AB - Aims: To estimate the prevalence, incidence, mortality, and risk of progression to type 2 diabetes for individuals with HbA1c-defined prediabetes based on Danish nationwide population-based laboratory databases. Methods: We included all HbA1c measurements from general practice and hospitals during 2012 to 2018. We estimated the cumulative incidence of having at least one HbA1c measurement. The prevalence and incidence rates of prediabetes (HbA1c 42–47 mmol/mol) were examined in the adult Danish population. The 5-year cumulative incidence of progression to type 2 diabetes was estimated with death as competing event. Results: Among 4,979,590 adult Danes, 70.8% (95% CI 70.8–70.9) had at least one HbA1c measurement during 2012 to 2018. The prevalence of prediabetes was 7.1% (95% CI 7.1–7.1) in 2018. The incidence rate was 14.2 (95% CI 14.1–14.3) per 1,000 person-years, with median age 66.9 years (IQR 56.7–75.7) and median HbA1c 43 mmol/mol (IQR 42–44) at prediabetes diagnosis. Within five years, 17.5% (95% CI 17.3–17.7) died and the 5-year cumulative incidence of type 2 diabetes was 21.3% (95% CI 21.1–21.5). Conclusions: Out of 100 Danish adults, 1.4 develop prediabetes each year and they can be identified at an early stage in laboratory databases. Within five years, one in five individuals with prediabetes progresses to diabetes and one in six dies.
KW - Glycated hemoglobin
KW - HbA1c
KW - Laboratory data
KW - Prediabetes incidence
KW - Prediabetes prevalence
KW - Type 2 diabetes
UR - http://www.scopus.com/inward/record.url?scp=85167410975&partnerID=8YFLogxK
U2 - 10.1016/j.diabres.2023.110829
DO - 10.1016/j.diabres.2023.110829
M3 - Journal article
C2 - 37451628
AN - SCOPUS:85167410975
SN - 0168-8227
VL - 203
JO - Diabetes Research and Clinical Practice
JF - Diabetes Research and Clinical Practice
M1 - 110829
ER -