Harmonizing neuropathic pain research: outcomes of the London consensus meeting on peripheral tissue studies

Sara Villa; Eske K Aasvang; Nadine Attal; Ralf Baron; Emmanuel Bourinet; Margarita Calvo; Nanna B Finnerup; Eleonora Galosi; James R F Hockley; Pall Karlsson; Harriet Kemp; Jannis Körner; Ekaterina Kutafina; Angelika Lampert; Margarita Mürk; Zahra Nochi; Theodore J Price; Andrew S C Rice; Claudia Sommer; Pille Taba; Andreas C Themistocleous; Rolf-Detlef Treede; Andrea Truini; Nurcan Üçeyler; David L Bennett; Annina B Schmid; Franziska Denk

doi:10.1097/j.pain.0000000000003445

Harmonizing neuropathic pain research: outcomes of the London consensus meeting on peripheral tissue studies

Sara Villa, Eske K Aasvang, Nadine Attal, Ralf Baron, Emmanuel Bourinet, Margarita Calvo, Nanna B Finnerup, Eleonora Galosi, James R F Hockley, Pall Karlsson, Harriet Kemp, Jannis Körner, Ekaterina Kutafina, Angelika Lampert, Margarita Mürk, Zahra Nochi, Theodore J Price, Andrew S C Rice, Claudia Sommer, Pille TabaAndreas C Themistocleous, Rolf-Detlef Treede, Andrea Truini, Nurcan Üçeyler, David L Bennett, Annina B Schmid, Franziska Denk

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

Abstract

Neuropathic pain remains difficult to treat, with drug development hampered by an incomplete understanding of the pathogenesis of the condition, as well as a lack of biomarkers. The problem is compounded by the scarcity of relevant human peripheral tissues, including skin, nerves, and dorsal root ganglia. Efforts to obtain such samples are accelerating, increasing the need for standardisation across laboratories. In this white paper, we report on a consensus meeting attended by neuropathic pain experts, designed to accelerate protocol alignment and harmonization of studies involving relevant peripheral tissues. The meeting was held in London in March 2024 and attended by 28 networking partners, including industry and patient representatives. We achieved consensus on minimal recommended phenotyping, harmonised wet laboratory protocols, statistical design, reporting, and data sharing. Here, we also share a variety of relevant standard operating procedures as supplementary protocols. We envision that our recommendations will help unify human tissue research in the field and accelerate our understanding of how abnormal interactions between sensory neurons and their local peripheral environment contribute towards neuropathic pain.

Original language	English
Article number	10.1097/j.pain.0000000000003445
Journal	Pain
ISSN	0304-3959
DOIs	https://doi.org/10.1097/j.pain.0000000000003445
Publication status	E-pub - 16 Oct 2024

Keywords

Dorsal root ganglia
Inflammation
Neuro-immune
Neuropathic pain
Peripheral nerve
Protocol harmonization

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10.1097/j.pain.0000000000003445

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Villa, S., Aasvang, E. K., Attal, N., Baron, R., Bourinet, E., Calvo, M., Finnerup, N. B., Galosi, E., Hockley, J. R. F., Karlsson, P., Kemp, H., Körner, J., Kutafina, E., Lampert, A., Mürk, M., Nochi, Z., Price, T. J., Rice, A. S. C., Sommer, C., ... Denk, F. (2024). Harmonizing neuropathic pain research: outcomes of the London consensus meeting on peripheral tissue studies. Pain, Article 10.1097/j.pain.0000000000003445. Advance online publication. https://doi.org/10.1097/j.pain.0000000000003445

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title = "Harmonizing neuropathic pain research: outcomes of the London consensus meeting on peripheral tissue studies",

abstract = "Neuropathic pain remains difficult to treat, with drug development hampered by an incomplete understanding of the pathogenesis of the condition, as well as a lack of biomarkers. The problem is compounded by the scarcity of relevant human peripheral tissues, including skin, nerves, and dorsal root ganglia. Efforts to obtain such samples are accelerating, increasing the need for standardisation across laboratories. In this white paper, we report on a consensus meeting attended by neuropathic pain experts, designed to accelerate protocol alignment and harmonization of studies involving relevant peripheral tissues. The meeting was held in London in March 2024 and attended by 28 networking partners, including industry and patient representatives. We achieved consensus on minimal recommended phenotyping, harmonised wet laboratory protocols, statistical design, reporting, and data sharing. Here, we also share a variety of relevant standard operating procedures as supplementary protocols. We envision that our recommendations will help unify human tissue research in the field and accelerate our understanding of how abnormal interactions between sensory neurons and their local peripheral environment contribute towards neuropathic pain.",

keywords = "Dorsal root ganglia, Inflammation, Neuro-immune, Neuropathic pain, Peripheral nerve, Protocol harmonization",

author = "Sara Villa and Aasvang, {Eske K} and Nadine Attal and Ralf Baron and Emmanuel Bourinet and Margarita Calvo and Finnerup, {Nanna B} and Eleonora Galosi and Hockley, {James R F} and Pall Karlsson and Harriet Kemp and Jannis K{\"o}rner and Ekaterina Kutafina and Angelika Lampert and Margarita M{\"u}rk and Zahra Nochi and Price, {Theodore J} and Rice, {Andrew S C} and Claudia Sommer and Pille Taba and Themistocleous, {Andreas C} and Rolf-Detlef Treede and Andrea Truini and Nurcan {\"U}{\c c}eyler and Bennett, {David L} and Schmid, {Annina B} and Franziska Denk",

note = "Copyright {\textcopyright} 2024 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the International Association for the Study of Pain.",

year = "2024",

month = oct,

day = "16",

doi = "10.1097/j.pain.0000000000003445",

language = "English",

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Villa, S, Aasvang, EK, Attal, N, Baron, R, Bourinet, E, Calvo, M, Finnerup, NB, Galosi, E, Hockley, JRF, Karlsson, P, Kemp, H, Körner, J, Kutafina, E, Lampert, A, Mürk, M, Nochi, Z, Price, TJ, Rice, ASC, Sommer, C, Taba, P, Themistocleous, AC, Treede, R-D, Truini, A, Üçeyler, N, Bennett, DL, Schmid, AB & Denk, F 2024, 'Harmonizing neuropathic pain research: outcomes of the London consensus meeting on peripheral tissue studies', Pain. https://doi.org/10.1097/j.pain.0000000000003445

TY - JOUR

T1 - Harmonizing neuropathic pain research

T2 - outcomes of the London consensus meeting on peripheral tissue studies

AU - Villa, Sara

AU - Aasvang, Eske K

AU - Attal, Nadine

AU - Baron, Ralf

AU - Bourinet, Emmanuel

AU - Calvo, Margarita

AU - Finnerup, Nanna B

AU - Galosi, Eleonora

AU - Hockley, James R F

AU - Karlsson, Pall

AU - Kemp, Harriet

AU - Körner, Jannis

AU - Kutafina, Ekaterina

AU - Lampert, Angelika

AU - Mürk, Margarita

AU - Nochi, Zahra

AU - Price, Theodore J

AU - Rice, Andrew S C

AU - Sommer, Claudia

AU - Taba, Pille

AU - Themistocleous, Andreas C

AU - Treede, Rolf-Detlef

AU - Truini, Andrea

AU - Üçeyler, Nurcan

AU - Bennett, David L

AU - Schmid, Annina B

AU - Denk, Franziska

PY - 2024/10/16

Y1 - 2024/10/16

N2 - Neuropathic pain remains difficult to treat, with drug development hampered by an incomplete understanding of the pathogenesis of the condition, as well as a lack of biomarkers. The problem is compounded by the scarcity of relevant human peripheral tissues, including skin, nerves, and dorsal root ganglia. Efforts to obtain such samples are accelerating, increasing the need for standardisation across laboratories. In this white paper, we report on a consensus meeting attended by neuropathic pain experts, designed to accelerate protocol alignment and harmonization of studies involving relevant peripheral tissues. The meeting was held in London in March 2024 and attended by 28 networking partners, including industry and patient representatives. We achieved consensus on minimal recommended phenotyping, harmonised wet laboratory protocols, statistical design, reporting, and data sharing. Here, we also share a variety of relevant standard operating procedures as supplementary protocols. We envision that our recommendations will help unify human tissue research in the field and accelerate our understanding of how abnormal interactions between sensory neurons and their local peripheral environment contribute towards neuropathic pain.

AB - Neuropathic pain remains difficult to treat, with drug development hampered by an incomplete understanding of the pathogenesis of the condition, as well as a lack of biomarkers. The problem is compounded by the scarcity of relevant human peripheral tissues, including skin, nerves, and dorsal root ganglia. Efforts to obtain such samples are accelerating, increasing the need for standardisation across laboratories. In this white paper, we report on a consensus meeting attended by neuropathic pain experts, designed to accelerate protocol alignment and harmonization of studies involving relevant peripheral tissues. The meeting was held in London in March 2024 and attended by 28 networking partners, including industry and patient representatives. We achieved consensus on minimal recommended phenotyping, harmonised wet laboratory protocols, statistical design, reporting, and data sharing. Here, we also share a variety of relevant standard operating procedures as supplementary protocols. We envision that our recommendations will help unify human tissue research in the field and accelerate our understanding of how abnormal interactions between sensory neurons and their local peripheral environment contribute towards neuropathic pain.

KW - Dorsal root ganglia

KW - Inflammation

KW - Neuro-immune

KW - Neuropathic pain

KW - Peripheral nerve

KW - Protocol harmonization

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U2 - 10.1097/j.pain.0000000000003445

DO - 10.1097/j.pain.0000000000003445

M3 - Journal article

C2 - 39432804

SN - 0304-3959

JO - Pain

JF - Pain

M1 - 10.1097/j.pain.0000000000003445

ER -

Harmonizing neuropathic pain research: outcomes of the London consensus meeting on peripheral tissue studies

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Keywords

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