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Harmonic Brain Modes: A Unifying Framework for Linking Space and Time in Brain Dynamics

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Harmonic Brain Modes : A Unifying Framework for Linking Space and Time in Brain Dynamics. / Atasoy, Selen; Deco, Gustavo; Kringelbach, Morten L; Pearson, Joel.

In: Neuroscientist, Vol. 24, No. 3, 06.2018, p. 277–293.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

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Atasoy, Selen ; Deco, Gustavo ; Kringelbach, Morten L ; Pearson, Joel. / Harmonic Brain Modes : A Unifying Framework for Linking Space and Time in Brain Dynamics. In: Neuroscientist. 2018 ; Vol. 24, No. 3. pp. 277–293.

Bibtex

@article{7c014efd0cc2465d927621c5fb7ace9e,
title = "Harmonic Brain Modes: A Unifying Framework for Linking Space and Time in Brain Dynamics",
abstract = "A fundamental characteristic of spontaneous brain activity is coherent oscillations covering a wide range of frequencies. Interestingly, these temporal oscillations are highly correlated among spatially distributed cortical areas forming structured correlation patterns known as the resting state networks, although the brain is never truly at {"}rest.{"} Here, we introduce the concept of harmonic brain modes-fundamental building blocks of complex spatiotemporal patterns of neural activity. We define these elementary harmonic brain modes as harmonic modes of structural connectivity; that is, connectome harmonics, yielding fully synchronous neural activity patterns with different frequency oscillations emerging on and constrained by the particular structure of the brain. Hence, this particular definition implicitly links the hitherto poorly understood dimensions of space and time in brain dynamics and its underlying anatomy. Further we show how harmonic brain modes can explain the relationship between neurophysiological, temporal, and network-level changes in the brain across different mental states ( wakefulness, sleep, anesthesia, psychedelic). Notably, when decoded as activation of connectome harmonics, spatial and temporal characteristics of neural activity naturally emerge from the interplay between excitation and inhibition and this critical relation fits the spatial, temporal, and neurophysiological changes associated with different mental states. Thus, the introduced framework of harmonic brain modes not only establishes a relation between the spatial structure of correlation patterns and temporal oscillations (linking space and time in brain dynamics), but also enables a new dimension of tools for understanding fundamental principles underlying brain dynamics in different states of consciousness.",
keywords = "Journal Article",
author = "Selen Atasoy and Gustavo Deco and Kringelbach, {Morten L} and Joel Pearson",
year = "2018",
month = jun,
doi = "10.1177/1073858417728032",
language = "English",
volume = "24",
pages = "277–293",
journal = "Neuroscientist",
issn = "1073-8584",
publisher = "Sage Publications, Inc.",
number = "3",

}

RIS

TY - JOUR

T1 - Harmonic Brain Modes

T2 - A Unifying Framework for Linking Space and Time in Brain Dynamics

AU - Atasoy, Selen

AU - Deco, Gustavo

AU - Kringelbach, Morten L

AU - Pearson, Joel

PY - 2018/6

Y1 - 2018/6

N2 - A fundamental characteristic of spontaneous brain activity is coherent oscillations covering a wide range of frequencies. Interestingly, these temporal oscillations are highly correlated among spatially distributed cortical areas forming structured correlation patterns known as the resting state networks, although the brain is never truly at "rest." Here, we introduce the concept of harmonic brain modes-fundamental building blocks of complex spatiotemporal patterns of neural activity. We define these elementary harmonic brain modes as harmonic modes of structural connectivity; that is, connectome harmonics, yielding fully synchronous neural activity patterns with different frequency oscillations emerging on and constrained by the particular structure of the brain. Hence, this particular definition implicitly links the hitherto poorly understood dimensions of space and time in brain dynamics and its underlying anatomy. Further we show how harmonic brain modes can explain the relationship between neurophysiological, temporal, and network-level changes in the brain across different mental states ( wakefulness, sleep, anesthesia, psychedelic). Notably, when decoded as activation of connectome harmonics, spatial and temporal characteristics of neural activity naturally emerge from the interplay between excitation and inhibition and this critical relation fits the spatial, temporal, and neurophysiological changes associated with different mental states. Thus, the introduced framework of harmonic brain modes not only establishes a relation between the spatial structure of correlation patterns and temporal oscillations (linking space and time in brain dynamics), but also enables a new dimension of tools for understanding fundamental principles underlying brain dynamics in different states of consciousness.

AB - A fundamental characteristic of spontaneous brain activity is coherent oscillations covering a wide range of frequencies. Interestingly, these temporal oscillations are highly correlated among spatially distributed cortical areas forming structured correlation patterns known as the resting state networks, although the brain is never truly at "rest." Here, we introduce the concept of harmonic brain modes-fundamental building blocks of complex spatiotemporal patterns of neural activity. We define these elementary harmonic brain modes as harmonic modes of structural connectivity; that is, connectome harmonics, yielding fully synchronous neural activity patterns with different frequency oscillations emerging on and constrained by the particular structure of the brain. Hence, this particular definition implicitly links the hitherto poorly understood dimensions of space and time in brain dynamics and its underlying anatomy. Further we show how harmonic brain modes can explain the relationship between neurophysiological, temporal, and network-level changes in the brain across different mental states ( wakefulness, sleep, anesthesia, psychedelic). Notably, when decoded as activation of connectome harmonics, spatial and temporal characteristics of neural activity naturally emerge from the interplay between excitation and inhibition and this critical relation fits the spatial, temporal, and neurophysiological changes associated with different mental states. Thus, the introduced framework of harmonic brain modes not only establishes a relation between the spatial structure of correlation patterns and temporal oscillations (linking space and time in brain dynamics), but also enables a new dimension of tools for understanding fundamental principles underlying brain dynamics in different states of consciousness.

KW - Journal Article

U2 - 10.1177/1073858417728032

DO - 10.1177/1073858417728032

M3 - Journal article

C2 - 28863720

VL - 24

SP - 277

EP - 293

JO - Neuroscientist

JF - Neuroscientist

SN - 1073-8584

IS - 3

ER -