Haemostatis activity in rectal cancer patients exposed to preoperative radiotherapy: a clinical prospective cohort study

Mogens Stender; Torben Larsen; Søren Lundbye-Christensen; Mette Yilmaz; Ole Thorlacius-Ussing

doi:10.1097/MBC.0b013e328329e4ae

Haemostatis activity in rectal cancer patients exposed to preoperative radiotherapy: a clinical prospective cohort study

Mogens Stender, Torben Larsen, Søren Lundbye-Christensen, Mette Yilmaz, Ole Thorlacius-Ussing

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

Abstract

To investigate whether markers of haemostasis activity increased during preoperative radiotherapy and whether postoperative marker levels were increased in irradiated rectal cancer patients when compared with nonirradiated rectal and colon cancer patients. In 45 rectal cancer patients, we measured plasma levels of prothrombin fragment 1 + 2 (F1 + 2), thrombin-antithrombin complex, and D-dimer during radiotherapy. Postoperative levels of F1 + 2, thrombin-antithrombin complex, and D-dimer in irradiated patients were compared with postoperative levels in 123 nonirradiated colon and rectal cancer patients. A small oscillation in F1 + 2 levels was observed during radiotherapy among long-term low-intensity radiotherapy recipients. Postoperative levels of F1 + 2 and D-dimer were significantly higher among patients who received short-term high-intensity radiotherapy. This study provided no evidence for activation of the haemostatic system during preoperative radiotherapy in patients with rectal cancer. Some evidence was provided for increased postoperative haemostatic activity among rectal cancer patients who received short-term high-intensity radiotherapy, when compared with patients who received long-term low-intensity radiotherapy, and nonirradiated patients.

Original language	English
Journal	Blood Coagulation and Fibrinolysis
Volume	20
Issue	4
Pages (from-to)	276-82
Number of pages	7
ISSN	0957-5235
DOIs	https://doi.org/10.1097/MBC.0b013e328329e4ae
Publication status	Published - 2009

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10.1097/MBC.0b013e328329e4ae

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@article{604596a028f711deaee0000ea68e967b,

title = "Haemostatis activity in rectal cancer patients exposed to preoperative radiotherapy: a clinical prospective cohort study",

abstract = "To investigate whether markers of haemostasis activity increased during preoperative radiotherapy and whether postoperative marker levels were increased in irradiated rectal cancer patients when compared with nonirradiated rectal and colon cancer patients. In 45 rectal cancer patients, we measured plasma levels of prothrombin fragment 1 + 2 (F1 + 2), thrombin-antithrombin complex, and D-dimer during radiotherapy. Postoperative levels of F1 + 2, thrombin-antithrombin complex, and D-dimer in irradiated patients were compared with postoperative levels in 123 nonirradiated colon and rectal cancer patients. A small oscillation in F1 + 2 levels was observed during radiotherapy among long-term low-intensity radiotherapy recipients. Postoperative levels of F1 + 2 and D-dimer were significantly higher among patients who received short-term high-intensity radiotherapy. This study provided no evidence for activation of the haemostatic system during preoperative radiotherapy in patients with rectal cancer. Some evidence was provided for increased postoperative haemostatic activity among rectal cancer patients who received short-term high-intensity radiotherapy, when compared with patients who received long-term low-intensity radiotherapy, and nonirradiated patients.",

author = "Mogens Stender and Torben Larsen and S{\o}ren Lundbye-Christensen and Mette Yilmaz and Ole Thorlacius-Ussing",

year = "2009",

doi = "10.1097/MBC.0b013e328329e4ae",

language = "English",

volume = "20",

pages = "276--82",

journal = "Blood Coagulation and Fibrinolysis",

issn = "0957-5235",

publisher = "LIPPINCOTT WILLIAMS & WILKINS",

number = "4",

}

Haemostatis activity in rectal cancer patients exposed to preoperative radiotherapy: a clinical prospective cohort study. / Stender, Mogens; Larsen, Torben; Lundbye-Christensen, Søren et al.
In: Blood Coagulation and Fibrinolysis, Vol. 20, No. 4, 2009, p. 276-82.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

TY - JOUR

T1 - Haemostatis activity in rectal cancer patients exposed to preoperative radiotherapy: a clinical prospective cohort study

AU - Stender, Mogens

AU - Larsen, Torben

AU - Lundbye-Christensen, Søren

AU - Yilmaz, Mette

AU - Thorlacius-Ussing, Ole

PY - 2009

Y1 - 2009

N2 - To investigate whether markers of haemostasis activity increased during preoperative radiotherapy and whether postoperative marker levels were increased in irradiated rectal cancer patients when compared with nonirradiated rectal and colon cancer patients. In 45 rectal cancer patients, we measured plasma levels of prothrombin fragment 1 + 2 (F1 + 2), thrombin-antithrombin complex, and D-dimer during radiotherapy. Postoperative levels of F1 + 2, thrombin-antithrombin complex, and D-dimer in irradiated patients were compared with postoperative levels in 123 nonirradiated colon and rectal cancer patients. A small oscillation in F1 + 2 levels was observed during radiotherapy among long-term low-intensity radiotherapy recipients. Postoperative levels of F1 + 2 and D-dimer were significantly higher among patients who received short-term high-intensity radiotherapy. This study provided no evidence for activation of the haemostatic system during preoperative radiotherapy in patients with rectal cancer. Some evidence was provided for increased postoperative haemostatic activity among rectal cancer patients who received short-term high-intensity radiotherapy, when compared with patients who received long-term low-intensity radiotherapy, and nonirradiated patients.

AB - To investigate whether markers of haemostasis activity increased during preoperative radiotherapy and whether postoperative marker levels were increased in irradiated rectal cancer patients when compared with nonirradiated rectal and colon cancer patients. In 45 rectal cancer patients, we measured plasma levels of prothrombin fragment 1 + 2 (F1 + 2), thrombin-antithrombin complex, and D-dimer during radiotherapy. Postoperative levels of F1 + 2, thrombin-antithrombin complex, and D-dimer in irradiated patients were compared with postoperative levels in 123 nonirradiated colon and rectal cancer patients. A small oscillation in F1 + 2 levels was observed during radiotherapy among long-term low-intensity radiotherapy recipients. Postoperative levels of F1 + 2 and D-dimer were significantly higher among patients who received short-term high-intensity radiotherapy. This study provided no evidence for activation of the haemostatic system during preoperative radiotherapy in patients with rectal cancer. Some evidence was provided for increased postoperative haemostatic activity among rectal cancer patients who received short-term high-intensity radiotherapy, when compared with patients who received long-term low-intensity radiotherapy, and nonirradiated patients.

U2 - 10.1097/MBC.0b013e328329e4ae

DO - 10.1097/MBC.0b013e328329e4ae

M3 - Journal article

C2 - 19318923

SN - 0957-5235

VL - 20

SP - 276

EP - 282

JO - Blood Coagulation and Fibrinolysis

JF - Blood Coagulation and Fibrinolysis

IS - 4

ER -

Haemostatis activity in rectal cancer patients exposed to preoperative radiotherapy: a clinical prospective cohort study

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