Department of Economics and Business Economics

GWAS of suicide attempt in psychiatric disorders and association with major depression polygenic risk scores

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  • Niamh Mullins, King's College London, Icahn School of Medicine at Mount Sinai
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  • Tim B. Bigdeli, State University of New York Downstate Medical Center, Virginia Commonwealth University
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  • Anders D. Børglum
  • Jonathan R.I. Coleman, King's College London
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  • Ditte Demontis
  • Divya Mehta, The University of Queensland, Queensland University of Technology QUT, SUNY Downstate Medical Center
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  • Robert A. Power, King's College London
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  • Stephan Ripke, Massachusetts General Hospital, Boston, Charite - Universitatsmedizin Berlin, Broad Institute, University of California Los Angeles
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  • Eli A. Stahl, Icahn School of Medicine at Mount Sinai, Broad Institute, University of California Los Angeles
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  • Anna Starnawska
  • Adebayo Anjorin, The National Institute for Health Research Collaboration for Leadership in Applied Health Research and Care West (NIHR CLAHRC West) at University Hospitals Bristol NHS Foundation Trust, Centre for Addiction and Mental Health
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  • Aiden Corvin, Trinity College Dublin
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  • Alan R. Sanders, University of Chicago, Chicago, Illinois., NorthShore University Health System and University of Chicago
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  • Andreas J. Forstner, University of Basel, F. Hoffmann-La Roche, University Hospital and University of Basel, University of Bonn
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  • Andreas Reif, University Hospital Frankfurt
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  • Anna C. Koller, University of Bonn
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  • Beata Swia Tkowska, Nofer Institute of Occupational Medicine
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  • Bernhard T. Baune, Melbourne Medical School, Westfälische Wilhelms-Universität Münster
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  • Bertram Müller-Myhsok, University of Liverpool, Max Planck Institute of Psychiatry, Munich Cluster for Systems Neurology (SyNergy)
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  • Brenda W.J.H. Penninx, VU University Medical Center
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  • Carlos Pato, SUNY Downstate Medical Center
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  • Clement Zai, Centre for Addiction and Mental Health
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  • Dan Rujescu, University Halle-Wittenberg, Ludwig-Maximilians-University München
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  • David M. Hougaard, Lundbeck Foundation Initiative for Integrative Psychiatric Research, Statens Serum Institut
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  • Digby Quested, Oxford University, Oxford, UK.
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  • Douglas F. Levinson, Stanford University
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  • Elisabeth B. Binder, King's College London, Max Planck Institute of Psychiatry, Emory University School of Medicine
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  • Enda M. Byrne, Social Genetic and Developmental Psychiatry Centre, King's College London, Institute for Molecular Bioscience, The University of Queensland
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  • Esben Agerbo
  • Fabian Streit, University Medical Centre Mannheim
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  • Fermin Mayoral, University Regional Hospital. Biomedicine Institute (IBIMA)
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  • Frank Bellivier, AP-HP Assistance Publique - Hopitaux de Paris, Fondamental Foundation, INSERM, Université Paris—Denis Diderot
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  • Franziska Degenhardt, University of Bonn
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  • Gerome Breen, King's College London
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  • Gunnar Morken, Norwegian University of Science and Technology, St Olavs Hospital, Trondheim University Hospital
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  • Gustavo Turecki, McGill University
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  • Guy A. Rouleau, McGill University, University Medicine Greifswald
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  • Hans J. Grabe, University Medicine Greifswald
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  • Henry Völzke, University Medicine Greifswald
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  • Ian Jones, Cardiff University
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  • Ina Giegling, University Halle-Wittenberg, Ludwig-Maximilians-University München
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  • Ingrid Agartz, Diakonhjemmet Hospital, Universitetet i Oslo, Karolinska Institutet
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  • Ingrid Melle, University of Oslo, Universitetet i Oslo
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  • Jacob Lawrence, North East London NHS Foundation Trust
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  • James T.R. Walters, Cardiff University
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  • Jana Strohmaier, University Medical Centre Mannheim
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  • Jianxin Shi, National Cancer Institute, Bratislava, Slovakia
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  • Ole Mors
  • Preben Bo Mortensen
  • Thomas Hansen, Lundbeck Foundation Initiative for Integrative Psychiatric Research, Institute of Biological Psychiatry, Mental Health Services Copenhagen
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  • Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, Bipolar Disorder Working Group of the Psychiatric Genomics Consortium, Schizophrenia Working Group of the Psychiatric Genomics Consortium

Objective: More than 90% of people who attempt suicide have a psychiatric diagnosis; however, twin and family studies suggest that the genetic etiology of suicide attempt is partially distinct from that of the psychiatric disorders themselves. The authors present the largest genome-wide association study (GWAS) on suicide attempt, using cohorts of individuals with major depressive disorder, bipolar disorder, and schizophrenia from the Psychiatric Genomics Consortium. Methods: The samples comprised 1,622 suicide attempters and 8,786 nonattempters with major depressive disorder; 3,264 attempters and 5,500 nonattempters with bipolar disorder; and 1,683 attempters and 2,946 nonattempters with schizophrenia. A GWAS on suicide attempt was performed by comparing attempters to nonattempters with each disorder, followed by a meta-analysis across disorders. Polygenic risk scoring was used to investigate the genetic relationship between suicide attempt and the psychiatric disorders. Results: Three genome-wide significant loci for suicide attempt were found: one associated with suicide attempt in major depressive disorder, one associated with suicide attempt in bipolar disorder, and one in the meta-analysis of suicide attempt in mood disorders. These associations were not replicated in independent mood disorder cohorts from the UK Biobank and iPSYCH. No significant associations were found in the meta-analysis of all three disorders. Polygenic risk scores for major depression were significantly associated with suicide attempt in major depressive disorder (R2= 0.25%), bipolar disorder (R2=0.24%), and schizophrenia (R2= 0.40%). Conclusions: This study provides new information on genetic associations and demonstrates that genetic liability for major depression increases risk for suicide attempt across psychiatric disorders. Further collaborative efforts to increase sample size may help to robustly identify genetic associations and provide biological insights into the etiology of suicide attempt.

Original languageEnglish
JournalAmerican Journal of Psychiatry
Volume176
Issue8
Pages (from-to)651-660
Number of pages10
ISSN0002-953X
DOIs
Publication statusPublished - Aug 2019

    Research areas

  • GENOME-WIDE ASSOCIATION, SCHIZOPHRENIA

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