Gut microbiota profiles of autism spectrum disorder and attention deficit/hyperactivity disorder: A systematic literature review

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperReviewResearchpeer-review

  • Caspar Bundgaard-Nielsen, Aalborg University, Aalborg University Hospital
  • ,
  • Julie Knudsen
  • Peter D C Leutscher, Aalborg University
  • ,
  • Marlene B Lauritsen, Aalborg University Hospital
  • ,
  • Mette Nyegaard
  • Søren Hagstrøm
  • Suzette Sørensen, Aalborg University

Accumulating evidence has implicated an involvement of the gut-brain axis in autism spectrum disorder (ASD) and attention-deficit hyperactivity disorder (ADHD), however with highly diverse results. This systematic review aims to describe and evaluate studies investigating the gut microbiota composition in individuals with ASD or ADHD and to evaluate if variations in gut microbiota are associated with these disorders.Twenty-four articles were identified in a systematic literature search of PubMed and Embase up to July 22, 2019. They consisted of 20 studies investigating ASD and four studies investigating ADHD. For ASD, several studies agreed on an overall difference in β-diversity, although no consistent bacterial variation between all studies was reported. For ADHD, the results were more diverse, with no clear differences observed.Several common characteristics in gut microbiota function were identified for ASD compared to controls. In contrast, highly heterogeneous results were reported for ADHD, and thus the association between gut microbiota composition and ADHD remains unclear. For both disorders, methodological differences hampered the comparison of studies.

Original languageEnglish
JournalGut Microbes
Pages (from-to)1172-1187
Number of pages16
Publication statusPublished - 2020

    Research areas

  • Autism Spectrum Disorder, attention-deficit hyperactivity disorder, gut-Brain axis, microbiome, microbiota, neurodevelopmental disorders, systematic Review

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