Gut microbiota differences in five-year-old children that were born preterm with a history of necrotizing enterocolitis: A pilot trial

Amanda Magnusson; Seyedeh Marziyeh Jabbari Shiadeh; Maryam Ardalan; Diana Swolin-Eide; Anders Elfvin

doi:10.1016/j.isci.2024.110325

Gut microbiota differences in five-year-old children that were born preterm with a history of necrotizing enterocolitis: A pilot trial

Amanda Magnusson^*, Seyedeh Marziyeh Jabbari Shiadeh, Maryam Ardalan, Diana Swolin-Eide, Anders Elfvin^*

^*Corresponding author for this work

Department of Clinical Medicine - Translational Neuropsychiatry Unit

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

Abstract

The study explores the long-term effects of necrotizing enterocolitis (NEC) on gut microbiota in preterm infants by analyzing stool samples from 5-year-old children using shotgun metagenomic sequencing. It compares children with a history of NEC, treated surgically or medically, to preterm controls without NEC. Findings reveal persistent gut microbiota dysbiosis in NEC children, with reduced species diversity and evenness, especially in those treated surgically. The surgical NEC group had a lower Shannon index, indicating less microbial diversity. Significant differences in taxonomic profiles were observed, mainly influenced by surgical treatment. These results underscore the lasting impact of NEC and its treatment on gut microbiota, suggesting a need for strategies addressing long-term dysbiosis.

Original language	English
Article number	110325
Journal	iScience
Volume	27
Issue	7
ISSN	2589-0042
DOIs	https://doi.org/10.1016/j.isci.2024.110325
Publication status	Published - Jul 2024

Keywords

gastroenterology
microbiome

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10.1016/j.isci.2024.110325Licence: CC BY

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title = "Gut microbiota differences in five-year-old children that were born preterm with a history of necrotizing enterocolitis: A pilot trial",

abstract = "The study explores the long-term effects of necrotizing enterocolitis (NEC) on gut microbiota in preterm infants by analyzing stool samples from 5-year-old children using shotgun metagenomic sequencing. It compares children with a history of NEC, treated surgically or medically, to preterm controls without NEC. Findings reveal persistent gut microbiota dysbiosis in NEC children, with reduced species diversity and evenness, especially in those treated surgically. The surgical NEC group had a lower Shannon index, indicating less microbial diversity. Significant differences in taxonomic profiles were observed, mainly influenced by surgical treatment. These results underscore the lasting impact of NEC and its treatment on gut microbiota, suggesting a need for strategies addressing long-term dysbiosis.",

keywords = "gastroenterology, microbiome",

author = "Amanda Magnusson and {Jabbari Shiadeh}, {Seyedeh Marziyeh} and Maryam Ardalan and Diana Swolin-Eide and Anders Elfvin",

note = "Publisher Copyright: {\textcopyright} 2024 The Authors",

year = "2024",

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doi = "10.1016/j.isci.2024.110325",

language = "English",

volume = "27",

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Gut microbiota differences in five-year-old children that were born preterm with a history of necrotizing enterocolitis: A pilot trial. / Magnusson, Amanda; Jabbari Shiadeh, Seyedeh Marziyeh; Ardalan, Maryam et al.
In: iScience, Vol. 27, No. 7, 110325, 07.2024.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

TY - JOUR

T1 - Gut microbiota differences in five-year-old children that were born preterm with a history of necrotizing enterocolitis

T2 - A pilot trial

AU - Magnusson, Amanda

AU - Jabbari Shiadeh, Seyedeh Marziyeh

AU - Ardalan, Maryam

AU - Swolin-Eide, Diana

AU - Elfvin, Anders

PY - 2024/7

Y1 - 2024/7

N2 - The study explores the long-term effects of necrotizing enterocolitis (NEC) on gut microbiota in preterm infants by analyzing stool samples from 5-year-old children using shotgun metagenomic sequencing. It compares children with a history of NEC, treated surgically or medically, to preterm controls without NEC. Findings reveal persistent gut microbiota dysbiosis in NEC children, with reduced species diversity and evenness, especially in those treated surgically. The surgical NEC group had a lower Shannon index, indicating less microbial diversity. Significant differences in taxonomic profiles were observed, mainly influenced by surgical treatment. These results underscore the lasting impact of NEC and its treatment on gut microbiota, suggesting a need for strategies addressing long-term dysbiosis.

AB - The study explores the long-term effects of necrotizing enterocolitis (NEC) on gut microbiota in preterm infants by analyzing stool samples from 5-year-old children using shotgun metagenomic sequencing. It compares children with a history of NEC, treated surgically or medically, to preterm controls without NEC. Findings reveal persistent gut microbiota dysbiosis in NEC children, with reduced species diversity and evenness, especially in those treated surgically. The surgical NEC group had a lower Shannon index, indicating less microbial diversity. Significant differences in taxonomic profiles were observed, mainly influenced by surgical treatment. These results underscore the lasting impact of NEC and its treatment on gut microbiota, suggesting a need for strategies addressing long-term dysbiosis.

KW - gastroenterology

KW - microbiome

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U2 - 10.1016/j.isci.2024.110325

DO - 10.1016/j.isci.2024.110325

M3 - Journal article

C2 - 39055941

AN - SCOPUS:85197610949

SN - 2589-0042

VL - 27

JO - iScience

JF - iScience

IS - 7

M1 - 110325

ER -

Gut microbiota differences in five-year-old children that were born preterm with a history of necrotizing enterocolitis: A pilot trial

Abstract

Keywords

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