Growth Hormone and Obesity

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperReviewResearchpeer-review

Growth hormone (GH) exerts IGF-I dependent protein anabolic and direct lipolytic effects. Obesity reversibly suppresses GH secretion driven by elevated FFA levels, whereas serum IGF-I levels remain normal or elevated due to elevated portal insulin levels. Fasting in lean individuals suppresses hepatic IGF-I production and increases pituitary GH release, but this pattern is less pronounced in obesity. Fasting in obesity is associated with increased sensitivity to the insulin-antagonistic effects of GH. GH treatment in obesity induces a moderate reduction in fat mass and an increase in lean body mass but the therapeutic potential is uncertain.

Original languageEnglish
JournalEndocrinology and Metabolism Clinics of North America
Volume49
Issue2
Pages (from-to)239-250
Number of pages12
ISSN0889-8529
DOIs
Publication statusPublished - 2020

    Research areas

  • Growth hormone, Insulin-like growth factor I, Obesity

See relations at Aarhus University Citationformats

ID: 185788191