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Growing vertical aligned mesoporous silica thin film on nanoporous substrate for enhanced degradation, drug delivery and bioactivity

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  • Zhe Li, Fourth Military Medical University
  • ,
  • Yide He, Fourth Military Medical University
  • ,
  • Lasse Hyldgaard Klausen
  • Ning Yan, Fourth Military Medical University
  • ,
  • Jing Liu, Fourth Military Medical University
  • ,
  • Fanghao Chen, Fourth Military Medical University
  • ,
  • Wen Song, State Key Laboratory of Military Stomatology & National Clinical Research Center for Oral Diseases & Shaanxi Key Laboratory of Oral Diseases, Fourth Military Medical University
  • ,
  • Mingdong Dong
  • Yumei Zhang, Fourth Military Medical University

Mesoporous silica thin film has been widely used in various fields, particularly the medical implant coating for drug delivery. However, some drawbacks remain with the films produced by traditional method (evaporation-induced self-assembly, EISA), such as the poor permeability caused by their horizontal aligned mesochannels. In this study, the vertical aligned mesoporous silica thin film (VMSTF) is uniformly grown alongside the walls of titania nanotubes array via a biphase stratification growth method, resulting in a hierarchical two-layered nanotubular structure. Due to the exposure of opened mesopores, VMSTF exhibits more appealing performances, including rapid degradation, efficient small-molecular drug (dexamethasone) loading and release, enhanced early adhesion and osteogenic differentiation of MC3T3-E1 cells. This is the first time successfully depositing VMSTF on nanoporous substrate and our findings suggest that the VMSTF may be a promising candidate for bone implant surface coating to obtain bioactive performances.

Original languageEnglish
JournalBioactive Materials
Pages (from-to)1452-1463
Number of pages12
Publication statusPublished - May 2021

    Research areas

  • Drug delivery, Mesoporous silica film, Osteoblasts, Titania nanotubes array, Vertical aligned mesochannels

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ID: 201551526