Grandmaternal High-fat Diet Primed Anxiety-like Behaviour in the Second-Generation Female Offspring

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Grandmaternal High-fat Diet Primed Anxiety-like Behaviour in the Second-Generation Female Offspring. / Winther, Gudrun; Eskelund, Amanda; Richter, Cecilie Bay et al.

In: Behavioural Brain Research, Vol. 359, 02.2019, p. 47-55.

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@article{bd574c666ac94c7395458200b4a73256,
title = "Grandmaternal High-fat Diet Primed Anxiety-like Behaviour in the Second-Generation Female Offspring",
abstract = "The health consequences of maternal obesity during pregnancy are disturbing as they may contribute to mental disorders in subsequent generations. We examine the influence of suboptimal grandmaternal diet on potential metabolic and mental health outcome of grand-progenies with a high-fat diet (HFD) manipulation in adulthood in a rat HFD model. Grandmaternal exposure to HFD exacerbated granddaughter's anxiety-like phenotype. Grandmaternal exposure to HFD led to upregulated corticotropin-releasing hormone receptor 2 mRNA expression involved in the stress axis in the male F2 offspring. Thus, we demonstrate that suboptimal grandmaternal diet prior to and during pregnancy and lactation may persist across subsequent generations. These findings have important implications for understanding both individual rates of metabolic and mental health problems and the clinical impact of current global trends towards comorbidity of obesity and depression and anxiety. In conclusion, the effect of grandmaternal HFD consumption during pregnancy on stress axis function and mental disorders may be transmitted to future generations.",
author = "Gudrun Winther and Amanda Eskelund and Richter, {Cecilie Bay} and Betina Elfving and M{\"u}ller, {Heidi Kaastrup} and Sten Lund and Gregers Wegener",
note = "Copyright {\textcopyright} 2018. Published by Elsevier B.V.",
year = "2019",
month = feb,
doi = "10.1016/j.bbr.2018.10.017",
language = "English",
volume = "359",
pages = "47--55",
journal = "Behavioural Brain Research",
issn = "0166-4328",
publisher = "Elsevier BV",

}

RIS

TY - JOUR

T1 - Grandmaternal High-fat Diet Primed Anxiety-like Behaviour in the Second-Generation Female Offspring

AU - Winther, Gudrun

AU - Eskelund, Amanda

AU - Richter, Cecilie Bay

AU - Elfving, Betina

AU - Müller, Heidi Kaastrup

AU - Lund, Sten

AU - Wegener, Gregers

N1 - Copyright © 2018. Published by Elsevier B.V.

PY - 2019/2

Y1 - 2019/2

N2 - The health consequences of maternal obesity during pregnancy are disturbing as they may contribute to mental disorders in subsequent generations. We examine the influence of suboptimal grandmaternal diet on potential metabolic and mental health outcome of grand-progenies with a high-fat diet (HFD) manipulation in adulthood in a rat HFD model. Grandmaternal exposure to HFD exacerbated granddaughter's anxiety-like phenotype. Grandmaternal exposure to HFD led to upregulated corticotropin-releasing hormone receptor 2 mRNA expression involved in the stress axis in the male F2 offspring. Thus, we demonstrate that suboptimal grandmaternal diet prior to and during pregnancy and lactation may persist across subsequent generations. These findings have important implications for understanding both individual rates of metabolic and mental health problems and the clinical impact of current global trends towards comorbidity of obesity and depression and anxiety. In conclusion, the effect of grandmaternal HFD consumption during pregnancy on stress axis function and mental disorders may be transmitted to future generations.

AB - The health consequences of maternal obesity during pregnancy are disturbing as they may contribute to mental disorders in subsequent generations. We examine the influence of suboptimal grandmaternal diet on potential metabolic and mental health outcome of grand-progenies with a high-fat diet (HFD) manipulation in adulthood in a rat HFD model. Grandmaternal exposure to HFD exacerbated granddaughter's anxiety-like phenotype. Grandmaternal exposure to HFD led to upregulated corticotropin-releasing hormone receptor 2 mRNA expression involved in the stress axis in the male F2 offspring. Thus, we demonstrate that suboptimal grandmaternal diet prior to and during pregnancy and lactation may persist across subsequent generations. These findings have important implications for understanding both individual rates of metabolic and mental health problems and the clinical impact of current global trends towards comorbidity of obesity and depression and anxiety. In conclusion, the effect of grandmaternal HFD consumption during pregnancy on stress axis function and mental disorders may be transmitted to future generations.

U2 - 10.1016/j.bbr.2018.10.017

DO - 10.1016/j.bbr.2018.10.017

M3 - Journal article

C2 - 30336180

VL - 359

SP - 47

EP - 55

JO - Behavioural Brain Research

JF - Behavioural Brain Research

SN - 0166-4328

ER -