Grandmaternal High-fat Diet Primed Anxiety-like Behaviour in the Second-Generation Female Offspring

Gudrun Winther; Amanda Eskelund; Cecilie Bay Richter; Betina Elfving; Heidi Kaastrup Müller; Sten Lund; Gregers Wegener

doi:10.1016/j.bbr.2018.10.017

Grandmaternal High-fat Diet Primed Anxiety-like Behaviour in the Second-Generation Female Offspring

Gudrun Winther, Amanda Eskelund, Cecilie Bay Richter, Betina Elfving, Heidi Kaastrup Müller, Sten Lund, Gregers Wegener

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

14 Citations (Scopus)

Abstract

The health consequences of maternal obesity during pregnancy are disturbing as they may contribute to mental disorders in subsequent generations. We examine the influence of suboptimal grandmaternal diet on potential metabolic and mental health outcome of grand-progenies with a high-fat diet (HFD) manipulation in adulthood in a rat HFD model. Grandmaternal exposure to HFD exacerbated granddaughter's anxiety-like phenotype. Grandmaternal exposure to HFD led to upregulated corticotropin-releasing hormone receptor 2 mRNA expression involved in the stress axis in the male F2 offspring. Thus, we demonstrate that suboptimal grandmaternal diet prior to and during pregnancy and lactation may persist across subsequent generations. These findings have important implications for understanding both individual rates of metabolic and mental health problems and the clinical impact of current global trends towards comorbidity of obesity and depression and anxiety. In conclusion, the effect of grandmaternal HFD consumption during pregnancy on stress axis function and mental disorders may be transmitted to future generations.

Original language	English
Journal	Behavioural Brain Research
Volume	359
Pages (from-to)	47-55
Number of pages	9
ISSN	0166-4328
DOIs	https://doi.org/10.1016/j.bbr.2018.10.017
Publication status	Published - Feb 2019

Keywords

Anxiety
Depression
High-fat diet
Intergenerational
Second-Generation
Sex differences

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10.1016/j.bbr.2018.10.017

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title = "Grandmaternal High-fat Diet Primed Anxiety-like Behaviour in the Second-Generation Female Offspring",

abstract = "The health consequences of maternal obesity during pregnancy are disturbing as they may contribute to mental disorders in subsequent generations. We examine the influence of suboptimal grandmaternal diet on potential metabolic and mental health outcome of grand-progenies with a high-fat diet (HFD) manipulation in adulthood in a rat HFD model. Grandmaternal exposure to HFD exacerbated granddaughter's anxiety-like phenotype. Grandmaternal exposure to HFD led to upregulated corticotropin-releasing hormone receptor 2 mRNA expression involved in the stress axis in the male F2 offspring. Thus, we demonstrate that suboptimal grandmaternal diet prior to and during pregnancy and lactation may persist across subsequent generations. These findings have important implications for understanding both individual rates of metabolic and mental health problems and the clinical impact of current global trends towards comorbidity of obesity and depression and anxiety. In conclusion, the effect of grandmaternal HFD consumption during pregnancy on stress axis function and mental disorders may be transmitted to future generations.",

keywords = "Anxiety, Depression, High-fat diet, Intergenerational, Second-Generation, Sex differences",

author = "Gudrun Winther and Amanda Eskelund and Richter, {Cecilie Bay} and Betina Elfving and M{\"u}ller, {Heidi Kaastrup} and Sten Lund and Gregers Wegener",

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year = "2019",

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doi = "10.1016/j.bbr.2018.10.017",

language = "English",

volume = "359",

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journal = "Behavioural Brain Research",

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Grandmaternal High-fat Diet Primed Anxiety-like Behaviour in the Second-Generation Female Offspring. / Winther, Gudrun; Eskelund, Amanda; Richter, Cecilie Bay et al.
In: Behavioural Brain Research, Vol. 359, 02.2019, p. 47-55.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

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T1 - Grandmaternal High-fat Diet Primed Anxiety-like Behaviour in the Second-Generation Female Offspring

AU - Winther, Gudrun

AU - Eskelund, Amanda

AU - Richter, Cecilie Bay

AU - Elfving, Betina

AU - Müller, Heidi Kaastrup

AU - Lund, Sten

AU - Wegener, Gregers

PY - 2019/2

Y1 - 2019/2

N2 - The health consequences of maternal obesity during pregnancy are disturbing as they may contribute to mental disorders in subsequent generations. We examine the influence of suboptimal grandmaternal diet on potential metabolic and mental health outcome of grand-progenies with a high-fat diet (HFD) manipulation in adulthood in a rat HFD model. Grandmaternal exposure to HFD exacerbated granddaughter's anxiety-like phenotype. Grandmaternal exposure to HFD led to upregulated corticotropin-releasing hormone receptor 2 mRNA expression involved in the stress axis in the male F2 offspring. Thus, we demonstrate that suboptimal grandmaternal diet prior to and during pregnancy and lactation may persist across subsequent generations. These findings have important implications for understanding both individual rates of metabolic and mental health problems and the clinical impact of current global trends towards comorbidity of obesity and depression and anxiety. In conclusion, the effect of grandmaternal HFD consumption during pregnancy on stress axis function and mental disorders may be transmitted to future generations.

AB - The health consequences of maternal obesity during pregnancy are disturbing as they may contribute to mental disorders in subsequent generations. We examine the influence of suboptimal grandmaternal diet on potential metabolic and mental health outcome of grand-progenies with a high-fat diet (HFD) manipulation in adulthood in a rat HFD model. Grandmaternal exposure to HFD exacerbated granddaughter's anxiety-like phenotype. Grandmaternal exposure to HFD led to upregulated corticotropin-releasing hormone receptor 2 mRNA expression involved in the stress axis in the male F2 offspring. Thus, we demonstrate that suboptimal grandmaternal diet prior to and during pregnancy and lactation may persist across subsequent generations. These findings have important implications for understanding both individual rates of metabolic and mental health problems and the clinical impact of current global trends towards comorbidity of obesity and depression and anxiety. In conclusion, the effect of grandmaternal HFD consumption during pregnancy on stress axis function and mental disorders may be transmitted to future generations.

KW - Anxiety

KW - Depression

KW - High-fat diet

KW - Intergenerational

KW - Second-Generation

KW - Sex differences

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DO - 10.1016/j.bbr.2018.10.017

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JO - Behavioural Brain Research

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ER -

Grandmaternal High-fat Diet Primed Anxiety-like Behaviour in the Second-Generation Female Offspring

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Keywords

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