Glycans in autophagy, endocytosis and lysosomal functions

Fulvio Reggiori; Hans-Joachim Gabius; Massimo Aureli; Winfried Römer; Sandro Sonnino; Eeva-Liisa Eskelinen

doi:10.1007/s10719-021-10007-x

Glycans in autophagy, endocytosis and lysosomal functions

Fulvio Reggiori, Hans-Joachim Gabius, Massimo Aureli, Winfried Römer, Sandro Sonnino, Eeva-Liisa Eskelinen

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Review › Research › peer-review

17 Citations (Scopus)

Abstract

Glycans have been shown to function as versatile molecular signals in cells. This prompted us to look at their roles in endocytosis, endolysosomal system and autophagy. We start by introducing the cell biological aspects of these pathways, the concept of the sugar code, and provide an overview on the role of glycans in the targeting of lysosomal proteins and in lysosomal functions. Moreover, we review evidence on the regulation of endocytosis and autophagy by glycans. Finally, we discuss the emerging concept that cytosolic exposure of luminal glycans, and their detection by endogenous lectins, provides a mechanism for the surveillance of the integrity of the endolysosomal compartments, and serves their eventual repair or disposal.

Original language	English
Journal	Glycoconjugate Journal
Volume	38
Issue	5
Pages (from-to)	625-647
Number of pages	23
ISSN	0282-0080
DOIs	https://doi.org/10.1007/s10719-021-10007-x
Publication status	Published - Oct 2021
Externally published	Yes

Keywords

Autophagy/physiology
Endocytosis/physiology
Gene Expression Regulation
Lysosomes/physiology
Polysaccharides/metabolism
Proteins/genetics

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10.1007/s10719-021-10007-x

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title = "Glycans in autophagy, endocytosis and lysosomal functions",

abstract = "Glycans have been shown to function as versatile molecular signals in cells. This prompted us to look at their roles in endocytosis, endolysosomal system and autophagy. We start by introducing the cell biological aspects of these pathways, the concept of the sugar code, and provide an overview on the role of glycans in the targeting of lysosomal proteins and in lysosomal functions. Moreover, we review evidence on the regulation of endocytosis and autophagy by glycans. Finally, we discuss the emerging concept that cytosolic exposure of luminal glycans, and their detection by endogenous lectins, provides a mechanism for the surveillance of the integrity of the endolysosomal compartments, and serves their eventual repair or disposal.",

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doi = "10.1007/s10719-021-10007-x",

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T1 - Glycans in autophagy, endocytosis and lysosomal functions

AU - Reggiori, Fulvio

AU - Gabius, Hans-Joachim

AU - Aureli, Massimo

AU - Römer, Winfried

AU - Sonnino, Sandro

AU - Eskelinen, Eeva-Liisa

PY - 2021/10

Y1 - 2021/10

N2 - Glycans have been shown to function as versatile molecular signals in cells. This prompted us to look at their roles in endocytosis, endolysosomal system and autophagy. We start by introducing the cell biological aspects of these pathways, the concept of the sugar code, and provide an overview on the role of glycans in the targeting of lysosomal proteins and in lysosomal functions. Moreover, we review evidence on the regulation of endocytosis and autophagy by glycans. Finally, we discuss the emerging concept that cytosolic exposure of luminal glycans, and their detection by endogenous lectins, provides a mechanism for the surveillance of the integrity of the endolysosomal compartments, and serves their eventual repair or disposal.

AB - Glycans have been shown to function as versatile molecular signals in cells. This prompted us to look at their roles in endocytosis, endolysosomal system and autophagy. We start by introducing the cell biological aspects of these pathways, the concept of the sugar code, and provide an overview on the role of glycans in the targeting of lysosomal proteins and in lysosomal functions. Moreover, we review evidence on the regulation of endocytosis and autophagy by glycans. Finally, we discuss the emerging concept that cytosolic exposure of luminal glycans, and their detection by endogenous lectins, provides a mechanism for the surveillance of the integrity of the endolysosomal compartments, and serves their eventual repair or disposal.

KW - Autophagy/physiology

KW - Endocytosis/physiology

KW - Gene Expression Regulation

KW - Lysosomes/physiology

KW - Polysaccharides/metabolism

KW - Proteins/genetics

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U2 - 10.1007/s10719-021-10007-x

DO - 10.1007/s10719-021-10007-x

M3 - Review

C2 - 34390447

SN - 0282-0080

VL - 38

SP - 625

EP - 647

JO - Glycoconjugate Journal

JF - Glycoconjugate Journal

IS - 5

ER -

Glycans in autophagy, endocytosis and lysosomal functions

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