Glucagon-Like Peptide-1: Effect on Kidney Hemodynamics and Renin-Angiotensin-Aldosterone System in Healthy Men

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  • Jeppe Skov, Denmark
  • Anders Dejgaard, Novo Nordisk A/S, Denmark
  • Jørgen Frøkiær
  • Jens Juul Holst, University of Copenhagen, Denmark
  • Thomas Jonassen, University of Copenhagen, Denmark
  • Søren Rittig
  • Jens Sandahl Christiansen, Denmark
Introduction:Glucagon-like peptide-1 (GLP-1) is an incretin hormone with multiple actions in addition to control of glucose homeostasis. GLP-1 is known to cause natriuresis in humans, but the effects on basic renal physiology are still partly unknown.Subjects and Methods:Twelve healthy young males were examined in a randomized, controlled, double-blinded, single-day, crossover trial to evaluate the effects of 2 hours GLP-1 infusion on kidney functions. Glomerular filtration rate (GFR) and renal plasma flow (RPF) were assessed with (51)Cr-EDTA and (123)I-hippuran, respectively, using a constant infusion renal clearance technique based on timed urine sampling.Results:GLP-1 had no significant effect on either GFR [+1.9%, 95% confidence interval (-0.8; 4.6%)] or RPF [+2.4%, 95% confidence interval (-3.6; 8.8%)]. Fractional urine excretion of lithium increased 9% (P = .013) and renal sodium clearance increased 40% (P = .007). Angiotensin II decreased 19% (P = .003), whereas renin, aldosterone, and the urinary excretion of angiotensinogen showed no significant changes. GLP-1 did not affect blood pressure but induced a small transient increase in heart rate.Conclusion:The results indicate that although GLP-1 markedly reduces proximal tubule sodium reabsorption, the acute effects on GFR and RPF are very limited in healthy humans. The finding of GLP-1's ability to reduce angiotensin II concentration is novel and should be further elucidated.
Original languageEnglish
JournalJournal of Clinical Endocrinology and Metabolism
Pages (from-to)E664-71
Number of pages8
Publication statusPublished - 5 Mar 2013

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