Giant cell tumour of bone in os sacrum of a prepubertal girl – Surgical and medical treatment with zoledronate and denosumab

Signe Sparre Beck-Nielsen; Henrik Hasle; Akmal Safwat; Kestutis Valancius; Bente Langdahl; Ebbe Stender Hansen

doi:10.1016/j.bonr.2023.101687

Giant cell tumour of bone in os sacrum of a prepubertal girl – Surgical and medical treatment with zoledronate and denosumab

Signe Sparre Beck-Nielsen^*, Henrik Hasle, Akmal Safwat, Kestutis Valancius, Bente Langdahl, Ebbe Stender Hansen

^*Corresponding author for this work

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

2 Citations (Scopus)

Abstract

A giant cell tumour of bone presented in the os sacrum of a prepubertal girl. Surgery with reconstruction was performed, but total resection was impossible. Zoledronate failed to avoid tumour regrowth, and treatment was changed to denosumab, despite not being recommended for use in growing children. Denosumab treatment for 21 months reduced and stabilized tumour size, the girl became pain free with asymptomatic side effects as mild hypocalcemia, hypophosphatemia and sclerosis of newly formed bone.

Original language	English
Article number	101687
Journal	Bone Reports
Volume	18
Number of pages	7
ISSN	2352-1872
DOIs	https://doi.org/10.1016/j.bonr.2023.101687
Publication status	Published - Jun 2023

Keywords

Bone markers
Bone specific alkaline phosphatase
Denosumab
Giant cell tumour of bone
Os sacrum
Prepubertal
Zoledronate

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title = "Giant cell tumour of bone in os sacrum of a prepubertal girl – Surgical and medical treatment with zoledronate and denosumab",

abstract = "A giant cell tumour of bone presented in the os sacrum of a prepubertal girl. Surgery with reconstruction was performed, but total resection was impossible. Zoledronate failed to avoid tumour regrowth, and treatment was changed to denosumab, despite not being recommended for use in growing children. Denosumab treatment for 21 months reduced and stabilized tumour size, the girl became pain free with asymptomatic side effects as mild hypocalcemia, hypophosphatemia and sclerosis of newly formed bone.",

keywords = "Bone markers, Bone specific alkaline phosphatase, Denosumab, Giant cell tumour of bone, Os sacrum, Prepubertal, Zoledronate",

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Giant cell tumour of bone in os sacrum of a prepubertal girl – Surgical and medical treatment with zoledronate and denosumab. / Beck-Nielsen, Signe Sparre ; Hasle, Henrik ; Safwat, Akmal et al.
In: Bone Reports, Vol. 18, 101687, 06.2023.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

TY - JOUR

T1 - Giant cell tumour of bone in os sacrum of a prepubertal girl – Surgical and medical treatment with zoledronate and denosumab

AU - Beck-Nielsen, Signe Sparre

AU - Hasle, Henrik

AU - Safwat, Akmal

AU - Valancius, Kestutis

AU - Langdahl, Bente

AU - Hansen, Ebbe Stender

PY - 2023/6

Y1 - 2023/6

N2 - A giant cell tumour of bone presented in the os sacrum of a prepubertal girl. Surgery with reconstruction was performed, but total resection was impossible. Zoledronate failed to avoid tumour regrowth, and treatment was changed to denosumab, despite not being recommended for use in growing children. Denosumab treatment for 21 months reduced and stabilized tumour size, the girl became pain free with asymptomatic side effects as mild hypocalcemia, hypophosphatemia and sclerosis of newly formed bone.

AB - A giant cell tumour of bone presented in the os sacrum of a prepubertal girl. Surgery with reconstruction was performed, but total resection was impossible. Zoledronate failed to avoid tumour regrowth, and treatment was changed to denosumab, despite not being recommended for use in growing children. Denosumab treatment for 21 months reduced and stabilized tumour size, the girl became pain free with asymptomatic side effects as mild hypocalcemia, hypophosphatemia and sclerosis of newly formed bone.

KW - Bone markers

KW - Bone specific alkaline phosphatase

KW - Denosumab

KW - Giant cell tumour of bone

KW - Os sacrum

KW - Prepubertal

KW - Zoledronate

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Giant cell tumour of bone in os sacrum of a prepubertal girl – Surgical and medical treatment with zoledronate and denosumab

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