Ghrelin, growth hormone and insulin-like growth Factor-I levels in people with protein C deficiency

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The primary objective of this study was to examine if people with protein C deficiency, which is a natural anticoagulant and also an endogenous acyl ghrelin peptidase, have elevated circulating levels of acyl ghrelin. The clinical trial was conducted in a university hospital setting. People with protein C deficiency were identified and invited to participate by a specialized coagulation outpatient clinic. People with protein C deficiency were examined and compared to age, sex, and body mass index matched healthy controls with regards to acyl ghrelin, unacylated ghrelin, growth hormone (GH) and insulin-like growth-factor I (IGF-I) in a cross-sectional case-control study. Systemic levels of acyl ghrelin, desacyl ghrelin, acyl-to-desacyl ghrelin ratio, GH and IGF-I were similar in people with protein C deficiency and healthy controls. Despite a significant reduction of protein C in people with protein C deficiency, there was no difference in acyl ghrelin or the secondary end points unacylated ghrelin, GH, or IGF-I in people with protein C deficiency.

Original languageEnglish
Book seriesScandinavian Journal of Clinical and Laboratory Investigation
Volume82
Issue6
Pages (from-to)435-438
Number of pages4
ISSN0085-591X
DOIs
Publication statusPublished - Oct 2022

    Research areas

  • Ghrelin, Ghrelin des-n-octanoyl, Insulin-like growth factor I, Protein C, protein C deficiency

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