Genomics using the Assembly of the Mink Genome

TY - GEN

T1 - Genomics using the Assembly of the Mink Genome

AU - Guldbrandtsen, Bernt

AU - Cai, Zexi

AU - Sahana, Goutam

AU - Villumsen, Trine Michelle

AU - Asp, Torben

AU - Thomsen, Bo

AU - Lund, Mogens Sandø

N1 - Conference code: 11

PY - 2018

Y1 - 2018

N2 - The American Mink’s (Neovison vison) genome has recently been sequenced. This opens numerous avenues of research both for studying the basic genetics and physiology of the mink as well as genetic improvement in mink. Using genotyping-by-sequencing (GBS) generated marker data for 2,352 Danish farm mink runs of homozygosity (ROH) were detect in mink genomes. Detectable ROH made up on average 1.7% of the genome indicating the presence of at most a moderate level of genomic inbreeding. The fraction of genome regions found in ROH varied. Ten percent of the included regions were never found in ROH. Other parts were in ROH in up to about 1/6 of the individuals. Some haplotypes must have achieved high frequencies during the relatively short time since domestication of the American mink. However, there was no evidence of haplotypes nearing fixation. Selection is therefore likely to be ongoing. The ability to detect ROH in the mink genome also demonstrates the general reliability of the new mink genome assembly. Keywords: american mink, run of homozygosity, genome, selection, genomic inbreeding

AB - The American Mink’s (Neovison vison) genome has recently been sequenced. This opens numerous avenues of research both for studying the basic genetics and physiology of the mink as well as genetic improvement in mink. Using genotyping-by-sequencing (GBS) generated marker data for 2,352 Danish farm mink runs of homozygosity (ROH) were detect in mink genomes. Detectable ROH made up on average 1.7% of the genome indicating the presence of at most a moderate level of genomic inbreeding. The fraction of genome regions found in ROH varied. Ten percent of the included regions were never found in ROH. Other parts were in ROH in up to about 1/6 of the individuals. Some haplotypes must have achieved high frequencies during the relatively short time since domestication of the American mink. However, there was no evidence of haplotypes nearing fixation. Selection is therefore likely to be ongoing. The ability to detect ROH in the mink genome also demonstrates the general reliability of the new mink genome assembly. Keywords: american mink, run of homozygosity, genome, selection, genomic inbreeding

M3 - Article in proceedings

BT - Proceedings of the World Congress on Genetics Applied to Livestock Production, 2018

T2 - The 11th World Congress on Genetics Applied to Livestock Production

Y2 - 11 February 2018 through 16 February 2018

ER -