Genomics of body fat percentage may contribute to sex bias in anorexia nervosa

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Standard

Genomics of body fat percentage may contribute to sex bias in anorexia nervosa. / Hübel, Christopher; Gaspar, Héléna A.; Coleman, Jonathan R.I.; Finucane, Hilary; Purves, Kirstin L.; Hanscombe, Ken B.; Prokopenko, Inga; Graff, Mariaelisa; Ngwa, Julius S.; Workalemahu, Tsegaselassie; O'Reilly, Paul F.; Bulik, Cynthia M.; Breen, Gerome; Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium; Schizophrenia Working Group of the Psychiatric Genomics Consortium; Tourette Syndrome/Obsessive-Compulsive Disorder Working Group of the Psychiatric Genomics Consortium; MAGIC Investigators; Eating Disorders Working Group of the Psychiatric Genomics Consortium ; Mattheisen, Manuel (Member of author collaboration); Grove, Jakob (Member of author collaboration); Mortensen, Preben Bo (Member of author collaboration).

In: American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics, Vol. 180, No. 6, 09.2019, p. 428-438.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Harvard

Hübel, C, Gaspar, HA, Coleman, JRI, Finucane, H, Purves, KL, Hanscombe, KB, Prokopenko, I, Graff, M, Ngwa, JS, Workalemahu, T, O'Reilly, PF, Bulik, CM, Breen, G, Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, Schizophrenia Working Group of the Psychiatric Genomics Consortium, Tourette Syndrome/Obsessive-Compulsive Disorder Working Group of the Psychiatric Genomics Consortium, MAGIC Investigators, Eating Disorders Working Group of the Psychiatric Genomics Consortium, Mattheisen, M, Grove, J & Mortensen, PB 2019, 'Genomics of body fat percentage may contribute to sex bias in anorexia nervosa', American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics, vol. 180, no. 6, pp. 428-438. https://doi.org/10.1002/ajmg.b.32709

APA

Hübel, C., Gaspar, H. A., Coleman, J. R. I., Finucane, H., Purves, K. L., Hanscombe, K. B., Prokopenko, I., Graff, M., Ngwa, J. S., Workalemahu, T., O'Reilly, P. F., Bulik, C. M., Breen, G., Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, Schizophrenia Working Group of the Psychiatric Genomics Consortium, Tourette Syndrome/Obsessive-Compulsive Disorder Working Group of the Psychiatric Genomics Consortium, MAGIC Investigators, Eating Disorders Working Group of the Psychiatric Genomics Consortium, Mattheisen, M., ... Mortensen, P. B. (2019). Genomics of body fat percentage may contribute to sex bias in anorexia nervosa. American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics, 180(6), 428-438. https://doi.org/10.1002/ajmg.b.32709

CBE

Hübel C, Gaspar HA, Coleman JRI, Finucane H, Purves KL, Hanscombe KB, Prokopenko I, Graff M, Ngwa JS, Workalemahu T, O'Reilly PF, Bulik CM, Breen G, Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, Schizophrenia Working Group of the Psychiatric Genomics Consortium, Tourette Syndrome/Obsessive-Compulsive Disorder Working Group of the Psychiatric Genomics Consortium, MAGIC Investigators, Eating Disorders Working Group of the Psychiatric Genomics Consortium, Mattheisen M, Grove J, Mortensen PB. 2019. Genomics of body fat percentage may contribute to sex bias in anorexia nervosa. American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics. 180(6):428-438. https://doi.org/10.1002/ajmg.b.32709

MLA

Hübel, Christopher et al. "Genomics of body fat percentage may contribute to sex bias in anorexia nervosa". American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics. 2019, 180(6). 428-438. https://doi.org/10.1002/ajmg.b.32709

Vancouver

Hübel C, Gaspar HA, Coleman JRI, Finucane H, Purves KL, Hanscombe KB et al. Genomics of body fat percentage may contribute to sex bias in anorexia nervosa. American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics. 2019 Sep;180(6):428-438. https://doi.org/10.1002/ajmg.b.32709

Author

Hübel, Christopher ; Gaspar, Héléna A. ; Coleman, Jonathan R.I. ; Finucane, Hilary ; Purves, Kirstin L. ; Hanscombe, Ken B. ; Prokopenko, Inga ; Graff, Mariaelisa ; Ngwa, Julius S. ; Workalemahu, Tsegaselassie ; O'Reilly, Paul F. ; Bulik, Cynthia M. ; Breen, Gerome ; Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium ; Schizophrenia Working Group of the Psychiatric Genomics Consortium ; Tourette Syndrome/Obsessive-Compulsive Disorder Working Group of the Psychiatric Genomics Consortium ; MAGIC Investigators ; Eating Disorders Working Group of the Psychiatric Genomics Consortium ; Mattheisen, Manuel ; Grove, Jakob ; Mortensen, Preben Bo. / Genomics of body fat percentage may contribute to sex bias in anorexia nervosa. In: American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics. 2019 ; Vol. 180, No. 6. pp. 428-438.

Bibtex

@article{56956a0f7a9e4a01928ce4928cf63e61,
title = "Genomics of body fat percentage may contribute to sex bias in anorexia nervosa",
abstract = "Anorexia nervosa (AN) occurs nine times more often in females than in males. Although environmental factors likely play a role, the reasons for this imbalanced sex ratio remain unresolved. AN displays high genetic correlations with anthropometric and metabolic traits. Given sex differences in body composition, we investigated the possible metabolic underpinnings of female propensity for AN. We conducted sex-specific GWAS in a healthy and medication-free subsample of the UK Biobank (n = 155,961), identifying 77 genome-wide significant loci associated with body fat percentage (BF%) and 174 with fat-free mass (FFM). Partitioned heritability analysis showed an enrichment for central nervous tissue-associated genes for BF%, which was more prominent in females than males. Genetic correlations of BF% and FFM with the largest GWAS of AN by the Psychiatric Genomics Consortium were estimated to explore shared genomics. The genetic correlations of BF%male and BF%female with AN differed significantly from each other (p <.0001, δ = −0.17), suggesting that the female preponderance in AN may, in part, be explained by sex-specific anthropometric and metabolic genetic factors increasing liability to AN.",
keywords = "eating disorder, fat-free mass, female, genetic correlation, GWAS, shared genetics, GENETIC-BASIS, METAANALYSIS, MASS INDEX, LOCI, HERITABILITY, RISK-FACTOR, GLYCEMIC TRAITS, POOLED ANALYSIS, WIDE ASSOCIATION, BIOLOGICAL INSIGHTS",
author = "Christopher H{\"u}bel and Gaspar, {H{\'e}l{\'e}na A.} and Coleman, {Jonathan R.I.} and Hilary Finucane and Purves, {Kirstin L.} and Hanscombe, {Ken B.} and Inga Prokopenko and Mariaelisa Graff and Ngwa, {Julius S.} and Tsegaselassie Workalemahu and O'Reilly, {Paul F.} and Bulik, {Cynthia M.} and Gerome Breen and {Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium} and {Schizophrenia Working Group of the Psychiatric Genomics Consortium} and {Tourette Syndrome/Obsessive-Compulsive Disorder Working Group of the Psychiatric Genomics Consortium} and {MAGIC Investigators} and {Eating Disorders Working Group of the Psychiatric Genomics Consortium} and Manuel Mattheisen and Jakob Grove and Mortensen, {Preben Bo}",
year = "2019",
month = sep,
doi = "10.1002/ajmg.b.32709",
language = "English",
volume = "180",
pages = "428--438",
journal = "American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics",
issn = "1552-4841",
publisher = "JohnWiley & Sons, Inc.",
number = "6",

}

RIS

TY - JOUR

T1 - Genomics of body fat percentage may contribute to sex bias in anorexia nervosa

AU - Hübel, Christopher

AU - Gaspar, Héléna A.

AU - Coleman, Jonathan R.I.

AU - Finucane, Hilary

AU - Purves, Kirstin L.

AU - Hanscombe, Ken B.

AU - Prokopenko, Inga

AU - Graff, Mariaelisa

AU - Ngwa, Julius S.

AU - Workalemahu, Tsegaselassie

AU - O'Reilly, Paul F.

AU - Bulik, Cynthia M.

AU - Breen, Gerome

AU - Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium

AU - Schizophrenia Working Group of the Psychiatric Genomics Consortium

AU - Tourette Syndrome/Obsessive-Compulsive Disorder Working Group of the Psychiatric Genomics Consortium

AU - MAGIC Investigators

AU - Eating Disorders Working Group of the Psychiatric Genomics Consortium

AU - Mattheisen, Manuel

AU - Grove, Jakob

AU - Mortensen, Preben Bo

PY - 2019/9

Y1 - 2019/9

N2 - Anorexia nervosa (AN) occurs nine times more often in females than in males. Although environmental factors likely play a role, the reasons for this imbalanced sex ratio remain unresolved. AN displays high genetic correlations with anthropometric and metabolic traits. Given sex differences in body composition, we investigated the possible metabolic underpinnings of female propensity for AN. We conducted sex-specific GWAS in a healthy and medication-free subsample of the UK Biobank (n = 155,961), identifying 77 genome-wide significant loci associated with body fat percentage (BF%) and 174 with fat-free mass (FFM). Partitioned heritability analysis showed an enrichment for central nervous tissue-associated genes for BF%, which was more prominent in females than males. Genetic correlations of BF% and FFM with the largest GWAS of AN by the Psychiatric Genomics Consortium were estimated to explore shared genomics. The genetic correlations of BF%male and BF%female with AN differed significantly from each other (p <.0001, δ = −0.17), suggesting that the female preponderance in AN may, in part, be explained by sex-specific anthropometric and metabolic genetic factors increasing liability to AN.

AB - Anorexia nervosa (AN) occurs nine times more often in females than in males. Although environmental factors likely play a role, the reasons for this imbalanced sex ratio remain unresolved. AN displays high genetic correlations with anthropometric and metabolic traits. Given sex differences in body composition, we investigated the possible metabolic underpinnings of female propensity for AN. We conducted sex-specific GWAS in a healthy and medication-free subsample of the UK Biobank (n = 155,961), identifying 77 genome-wide significant loci associated with body fat percentage (BF%) and 174 with fat-free mass (FFM). Partitioned heritability analysis showed an enrichment for central nervous tissue-associated genes for BF%, which was more prominent in females than males. Genetic correlations of BF% and FFM with the largest GWAS of AN by the Psychiatric Genomics Consortium were estimated to explore shared genomics. The genetic correlations of BF%male and BF%female with AN differed significantly from each other (p <.0001, δ = −0.17), suggesting that the female preponderance in AN may, in part, be explained by sex-specific anthropometric and metabolic genetic factors increasing liability to AN.

KW - eating disorder

KW - fat-free mass

KW - female

KW - genetic correlation

KW - GWAS

KW - shared genetics

KW - GENETIC-BASIS

KW - METAANALYSIS

KW - MASS INDEX

KW - LOCI

KW - HERITABILITY

KW - RISK-FACTOR

KW - GLYCEMIC TRAITS

KW - POOLED ANALYSIS

KW - WIDE ASSOCIATION

KW - BIOLOGICAL INSIGHTS

UR - http://www.scopus.com/inward/record.url?scp=85059291248&partnerID=8YFLogxK

U2 - 10.1002/ajmg.b.32709

DO - 10.1002/ajmg.b.32709

M3 - Journal article

C2 - 30593698

AN - SCOPUS:85059291248

VL - 180

SP - 428

EP - 438

JO - American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics

JF - American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics

SN - 1552-4841

IS - 6

ER -