Genome-Wide Association Study Reveals Genetic Architecture of Eating Behaviors in Pigs and its Implications for Humans Obesity by Comparative Genome Mapping

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  • Duy Ngoc Do, Department of Clinical Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark
  • Anders Bjerring Strathe, Department of Clinical Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark
  • Tage Ostersen, Danish Agriculture & Food Council, Pig Research Centre, Denmark
  • Just Jensen
  • Thomas Mark, Department of Clinical Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark
  • Haja Kadarmideen, Department of Clinical Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark
This study was aimed at identifying genomic regions controlling feeding behaviors inDanish Duroc boars and its potential implications for eating behaviors in humans.Individual daily feed intake (DFI), total daily time spent in feeder (TPD), number of dailyvisits to feeder (NVD), time spent to eat per visit (TPV), mean feed intake per visit(FPV) and mean feed intake rate (FR) were available on 1130 boars. All boars weregenotyped using the Illumina Porcine SNP60 BeadChip. The association analyseswere performed using the GenABEL package in R. Sixteen SNPs had moderategenome-wide significant (p < 5E-05) and 76 SNPs had suggestive (p < 5E-04)association with feeding behavior traits. Locus M1GA0016584 located close to theMSI2 gene on chromosome (SSC) 14 was very strongly associated with NVD (p =9.6E-07). Thirty six SNPs were located in genome regions where QTLs havepreviously been reported for behaviors and/or feed intake traits in pigs. The regions:64-65Mb on SSC 1, 124-130Mb on SSC 8, 63-68Mb on SSC 11, 32-39Mb and 59-60Mb on SSC 12 harbored several significant SNPs. Three and two haplotypes thatwere detected in significant regions on SSC1 and SSC12 affected DFI and NVD,respectively. Synapse, dephosphorylation and positive regulation of peptide secretiongenes were found highly significantly associated with feeding behavior traits byfunctional annotation. This is the first GWAS to identify genetic variants and biologicalmechanisms for feeding behavior in pigs and these results are important for geneticimprovement of pig feed efficiency. The results of pig-human comparative genemapping revealed some important genomic regions and/or genes on the humangenome that may influence eating behavior in human and consequently affect thedevelopment of obesity and metabolic syndromes. This is the first such translationalgenomics study to report potential candidate genes for eating behavior in humans
Original languageEnglish
Article numbere71509
JournalP L o S One
Volume8
Issue8
Pages (from-to)1-14
Number of pages14
ISSN1932-6203
Publication statusPublished - 19 Aug 2013

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