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Genome-wide association study of the sensitivity to environmental stress and adversity neuroticism cluster

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Neuroticism is a highly heritable personality trait, characterized by emotions such as guilt, loneliness, embarrassment and being easily hurt. Individuals with high levels of neuroticism are at increased risk of developing mental disorders, depression in particular.1 Neuroticism is commonly measured using the 12-item version of the Eysenck Personality Questionnaire (EPQ).2 A recent genome-wide association study (GWAS) of approximately 370.000 EPQ responders by Nagel et al.3 identified two genetically distinct neuroticism clusters: "depressed affect" and "worry", each defined by four of the 12 EPQ questions.

Original languageEnglish
JournalActa Psychiatrica Scandinavica
Pages (from-to)476-478
Number of pages3
Publication statusPublished - May 2020

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© 2020 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

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