Genome-wide association study in Chinese Holstein cows reveal two candidate genes for somatic cell score as an indicator for mastitis susceptibility

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  • Xiao Wang, Key Laboratory of Animal Genetics, China Agricultural University
  • ,
  • Peipei Ma, Key Laboratory of Animal Genetics, China Agricultural University
  • ,
  • Jianfeng Liu, China Agricultural University
  • ,
  • Qin Zhang
  • Yuan Zhang, Key Laboratory of Animal Genetics, China Agricultural University
  • ,
  • Xiangdong Ding, China Agricultural University
  • ,
  • Li Jiang, Key Laboratory of Animal Genetics, China Agricultural University
  • ,
  • Yachun Wang, China Agricultural University
  • ,
  • Yi Zhang, China Agricultural University
  • ,
  • Dongxiao Sun, China Agricultural University
  • ,
  • Shengli Zhang, China Agricultural University
  • ,
  • Guosheng Su
  • Ying Yu, China Agricultural University
  • ,
  • Yuan Zhang, College of Animal Science and Technology, China Agricultural University, China

Backgrounds: Bovine mastitis is a typical inflammatory disease causing seriously economic loss. Genome-wide association study (GWAS) can be a powerful method to promote marker assistant selection of this kind of complex disease. The present study aimed to analyze and identify single nucleotide polymorphisms (SNPs) and candidate genes that associated with mastitis susceptibility traits in Chinese Holstein. Results: Forty eight SNPs were identified significantly associated with mastitis resistance traits in Chinese Holstein cows, which are mainly located on the BTA 14. A total of 41 significant SNPs were linked to 31 annotated bovine genes. Gene Ontology and pathway enrichment revealed 5 genes involved in 32 pathways, in which, TRAPPC9 and ARHGAP39 genes participate cell differentiation and developmental pathway together. The six common genome-wide significant SNPs are found located within TRAPPC9 and flanking ARHGAP39 genes. Conclusions: Our data identified the six SNPs significantly associated with SCS EBVs, which suggest that their linked two genes (TRAPPC9 and ARHGAP39) are novel candidate genes of mastitis susceptibility in Holsteins.

Original languageEnglish
Article number111
JournalBMC Genetics
Volume16
Issue1
ISSN1471-2156
DOIs
Publication statusPublished - 2015

    Research areas

  • Chinese Holstein cows, EBVs of somatic cell scores, Genome-wide association study, Mastitis susceptibility, Mixed model based single locus regression analysis

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