Department of Economics and Business Economics

Genome-wide association study identifies 30 loci associated with bipolar disorder

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Standard

Genome-wide association study identifies 30 loci associated with bipolar disorder. / Stahl, Eli A; Breen, Gerome; Forstner, Andreas J; McQuillin, Andrew; Ripke, Stephan; Trubetskoy, Vassily; Mattheisen, Manuel; Wang, Yunpeng; Coleman, Jonathan R I; Gaspar, Héléna A; de Leeuw, Christiaan A; Steinberg, Stacy; Pavlides, Jennifer M Whitehead; Trzaskowski, Maciej; Byrne, Enda M; Pers, Tune H; Holmans, Peter A; Richards, Alexander L; Abbott, Liam; Agerbo, Esben; Akil, Huda; Albani, Diego; Alliey-Rodriguez, Ney; Als, Thomas D; Anjorin, Adebayo; Antilla, Verneri; Awasthi, Swapnil; Badner, Judith A; Bækvad-Hansen, Marie; Barchas, Jack D; Bass, Nicholas; Bauer, Michael; Belliveau, Richard; Bergen, Sarah E; Pedersen, Carsten Bøcker; Bøen, Erlend; Boks, Marco P; Boocock, James; Budde, Monika; Bunney, William; Burmeister, Margit; Bybjerg-Grauholm, Jonas; Byerley, William; Pedersen, Marianne Giørtz; Grove, Jakob; Xu, Wei; Zhang, Peng; Børglum, Anders D; Mors, Ole; Mortensen, Preben Bo; eQTLGen Consortium.

In: Nature Genetics, Vol. 51, No. 5, 05.2019, p. 793-803.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Harvard

Stahl, EA, Breen, G, Forstner, AJ, McQuillin, A, Ripke, S, Trubetskoy, V, Mattheisen, M, Wang, Y, Coleman, JRI, Gaspar, HA, de Leeuw, CA, Steinberg, S, Pavlides, JMW, Trzaskowski, M, Byrne, EM, Pers, TH, Holmans, PA, Richards, AL, Abbott, L, Agerbo, E, Akil, H, Albani, D, Alliey-Rodriguez, N, Als, TD, Anjorin, A, Antilla, V, Awasthi, S, Badner, JA, Bækvad-Hansen, M, Barchas, JD, Bass, N, Bauer, M, Belliveau, R, Bergen, SE, Pedersen, CB, Bøen, E, Boks, MP, Boocock, J, Budde, M, Bunney, W, Burmeister, M, Bybjerg-Grauholm, J, Byerley, W, Pedersen, MG, Grove, J, Xu, W, Zhang, P, Børglum, AD, Mors, O, Mortensen, PB & eQTLGen Consortium 2019, 'Genome-wide association study identifies 30 loci associated with bipolar disorder', Nature Genetics, vol. 51, no. 5, pp. 793-803. https://doi.org/10.1038/s41588-019-0397-8

APA

Stahl, E. A., Breen, G., Forstner, A. J., McQuillin, A., Ripke, S., Trubetskoy, V., Mattheisen, M., Wang, Y., Coleman, J. R. I., Gaspar, H. A., de Leeuw, C. A., Steinberg, S., Pavlides, J. M. W., Trzaskowski, M., Byrne, E. M., Pers, T. H., Holmans, P. A., Richards, A. L., Abbott, L., ... eQTLGen Consortium (2019). Genome-wide association study identifies 30 loci associated with bipolar disorder. Nature Genetics, 51(5), 793-803. https://doi.org/10.1038/s41588-019-0397-8

CBE

Stahl EA, Breen G, Forstner AJ, McQuillin A, Ripke S, Trubetskoy V, Mattheisen M, Wang Y, Coleman JRI, Gaspar HA, de Leeuw CA, Steinberg S, Pavlides JMW, Trzaskowski M, Byrne EM, Pers TH, Holmans PA, Richards AL, Abbott L, Agerbo E, Akil H, Albani D, Alliey-Rodriguez N, Als TD, Anjorin A, Antilla V, Awasthi S, Badner JA, Bækvad-Hansen M, Barchas JD, Bass N, Bauer M, Belliveau R, Bergen SE, Pedersen CB, Bøen E, Boks MP, Boocock J, Budde M, Bunney W, Burmeister M, Bybjerg-Grauholm J, Byerley W, Pedersen MG, Grove J, Xu W, Zhang P, Børglum AD, Mors O, Mortensen PB, eQTLGen Consortium. 2019. Genome-wide association study identifies 30 loci associated with bipolar disorder. Nature Genetics. 51(5):793-803. https://doi.org/10.1038/s41588-019-0397-8

MLA

Vancouver

Stahl EA, Breen G, Forstner AJ, McQuillin A, Ripke S, Trubetskoy V et al. Genome-wide association study identifies 30 loci associated with bipolar disorder. Nature Genetics. 2019 May;51(5):793-803. https://doi.org/10.1038/s41588-019-0397-8

Author

Stahl, Eli A ; Breen, Gerome ; Forstner, Andreas J ; McQuillin, Andrew ; Ripke, Stephan ; Trubetskoy, Vassily ; Mattheisen, Manuel ; Wang, Yunpeng ; Coleman, Jonathan R I ; Gaspar, Héléna A ; de Leeuw, Christiaan A ; Steinberg, Stacy ; Pavlides, Jennifer M Whitehead ; Trzaskowski, Maciej ; Byrne, Enda M ; Pers, Tune H ; Holmans, Peter A ; Richards, Alexander L ; Abbott, Liam ; Agerbo, Esben ; Akil, Huda ; Albani, Diego ; Alliey-Rodriguez, Ney ; Als, Thomas D ; Anjorin, Adebayo ; Antilla, Verneri ; Awasthi, Swapnil ; Badner, Judith A ; Bækvad-Hansen, Marie ; Barchas, Jack D ; Bass, Nicholas ; Bauer, Michael ; Belliveau, Richard ; Bergen, Sarah E ; Pedersen, Carsten Bøcker ; Bøen, Erlend ; Boks, Marco P ; Boocock, James ; Budde, Monika ; Bunney, William ; Burmeister, Margit ; Bybjerg-Grauholm, Jonas ; Byerley, William ; Pedersen, Marianne Giørtz ; Grove, Jakob ; Xu, Wei ; Zhang, Peng ; Børglum, Anders D ; Mors, Ole ; Mortensen, Preben Bo ; eQTLGen Consortium. / Genome-wide association study identifies 30 loci associated with bipolar disorder. In: Nature Genetics. 2019 ; Vol. 51, No. 5. pp. 793-803.

Bibtex

@article{353c46e3c8c849bfa513e615a7c94d44,
title = "Genome-wide association study identifies 30 loci associated with bipolar disorder",
abstract = "Bipolar disorder is a highly heritable psychiatric disorder. We performed a genome-wide association study (GWAS) including 20,352 cases and 31,358 controls of European descent, with follow-up analysis of 822 variants with P < 1 × 10-4 in an additional 9,412 cases and 137,760 controls. Eight of the 19 variants that were genome-wide significant (P < 5 × 10-8) in the discovery GWAS were not genome-wide significant in the combined analysis, consistent with small effect sizes and limited power but also with genetic heterogeneity. In the combined analysis, 30 loci were genome-wide significant, including 20 newly identified loci. The significant loci contain genes encoding ion channels, neurotransmitter transporters and synaptic components. Pathway analysis revealed nine significantly enriched gene sets, including regulation of insulin secretion and endocannabinoid signaling. Bipolar I disorder is strongly genetically correlated with schizophrenia, driven by psychosis, whereas bipolar II disorder is more strongly correlated with major depressive disorder. These findings address key clinical questions and provide potential biological mechanisms for bipolar disorder.",
keywords = "GENES, GWAS, HERITABILITY, INDIVIDUALS, LD SCORE REGRESSION, METAANALYSIS, POLYGENICITY, RISK, SCHIZOPHRENIA, VARIANTS",
author = "Stahl, {Eli A} and Gerome Breen and Forstner, {Andreas J} and Andrew McQuillin and Stephan Ripke and Vassily Trubetskoy and Manuel Mattheisen and Yunpeng Wang and Coleman, {Jonathan R I} and Gaspar, {H{\'e}l{\'e}na A} and {de Leeuw}, {Christiaan A} and Stacy Steinberg and Pavlides, {Jennifer M Whitehead} and Maciej Trzaskowski and Byrne, {Enda M} and Pers, {Tune H} and Holmans, {Peter A} and Richards, {Alexander L} and Liam Abbott and Esben Agerbo and Huda Akil and Diego Albani and Ney Alliey-Rodriguez and Als, {Thomas D} and Adebayo Anjorin and Verneri Antilla and Swapnil Awasthi and Badner, {Judith A} and Marie B{\ae}kvad-Hansen and Barchas, {Jack D} and Nicholas Bass and Michael Bauer and Richard Belliveau and Bergen, {Sarah E} and Pedersen, {Carsten B{\o}cker} and Erlend B{\o}en and Boks, {Marco P} and James Boocock and Monika Budde and William Bunney and Margit Burmeister and Jonas Bybjerg-Grauholm and William Byerley and Pedersen, {Marianne Gi{\o}rtz} and Jakob Grove and Wei Xu and Peng Zhang and B{\o}rglum, {Anders D} and Ole Mors and Mortensen, {Preben Bo} and {eQTLGen Consortium}",
year = "2019",
month = may,
doi = "10.1038/s41588-019-0397-8",
language = "English",
volume = "51",
pages = "793--803",
journal = "Nature Genetics",
issn = "1061-4036",
publisher = "Nature Publishing Group",
number = "5",

}

RIS

TY - JOUR

T1 - Genome-wide association study identifies 30 loci associated with bipolar disorder

AU - Stahl, Eli A

AU - Breen, Gerome

AU - Forstner, Andreas J

AU - McQuillin, Andrew

AU - Ripke, Stephan

AU - Trubetskoy, Vassily

AU - Mattheisen, Manuel

AU - Wang, Yunpeng

AU - Coleman, Jonathan R I

AU - Gaspar, Héléna A

AU - de Leeuw, Christiaan A

AU - Steinberg, Stacy

AU - Pavlides, Jennifer M Whitehead

AU - Trzaskowski, Maciej

AU - Byrne, Enda M

AU - Pers, Tune H

AU - Holmans, Peter A

AU - Richards, Alexander L

AU - Abbott, Liam

AU - Agerbo, Esben

AU - Akil, Huda

AU - Albani, Diego

AU - Alliey-Rodriguez, Ney

AU - Als, Thomas D

AU - Anjorin, Adebayo

AU - Antilla, Verneri

AU - Awasthi, Swapnil

AU - Badner, Judith A

AU - Bækvad-Hansen, Marie

AU - Barchas, Jack D

AU - Bass, Nicholas

AU - Bauer, Michael

AU - Belliveau, Richard

AU - Bergen, Sarah E

AU - Pedersen, Carsten Bøcker

AU - Bøen, Erlend

AU - Boks, Marco P

AU - Boocock, James

AU - Budde, Monika

AU - Bunney, William

AU - Burmeister, Margit

AU - Bybjerg-Grauholm, Jonas

AU - Byerley, William

AU - Pedersen, Marianne Giørtz

AU - Grove, Jakob

AU - Xu, Wei

AU - Zhang, Peng

AU - Børglum, Anders D

AU - Mors, Ole

AU - Mortensen, Preben Bo

AU - eQTLGen Consortium

PY - 2019/5

Y1 - 2019/5

N2 - Bipolar disorder is a highly heritable psychiatric disorder. We performed a genome-wide association study (GWAS) including 20,352 cases and 31,358 controls of European descent, with follow-up analysis of 822 variants with P < 1 × 10-4 in an additional 9,412 cases and 137,760 controls. Eight of the 19 variants that were genome-wide significant (P < 5 × 10-8) in the discovery GWAS were not genome-wide significant in the combined analysis, consistent with small effect sizes and limited power but also with genetic heterogeneity. In the combined analysis, 30 loci were genome-wide significant, including 20 newly identified loci. The significant loci contain genes encoding ion channels, neurotransmitter transporters and synaptic components. Pathway analysis revealed nine significantly enriched gene sets, including regulation of insulin secretion and endocannabinoid signaling. Bipolar I disorder is strongly genetically correlated with schizophrenia, driven by psychosis, whereas bipolar II disorder is more strongly correlated with major depressive disorder. These findings address key clinical questions and provide potential biological mechanisms for bipolar disorder.

AB - Bipolar disorder is a highly heritable psychiatric disorder. We performed a genome-wide association study (GWAS) including 20,352 cases and 31,358 controls of European descent, with follow-up analysis of 822 variants with P < 1 × 10-4 in an additional 9,412 cases and 137,760 controls. Eight of the 19 variants that were genome-wide significant (P < 5 × 10-8) in the discovery GWAS were not genome-wide significant in the combined analysis, consistent with small effect sizes and limited power but also with genetic heterogeneity. In the combined analysis, 30 loci were genome-wide significant, including 20 newly identified loci. The significant loci contain genes encoding ion channels, neurotransmitter transporters and synaptic components. Pathway analysis revealed nine significantly enriched gene sets, including regulation of insulin secretion and endocannabinoid signaling. Bipolar I disorder is strongly genetically correlated with schizophrenia, driven by psychosis, whereas bipolar II disorder is more strongly correlated with major depressive disorder. These findings address key clinical questions and provide potential biological mechanisms for bipolar disorder.

KW - GENES

KW - GWAS

KW - HERITABILITY

KW - INDIVIDUALS

KW - LD SCORE REGRESSION

KW - METAANALYSIS

KW - POLYGENICITY

KW - RISK

KW - SCHIZOPHRENIA

KW - VARIANTS

U2 - 10.1038/s41588-019-0397-8

DO - 10.1038/s41588-019-0397-8

M3 - Journal article

C2 - 31043756

VL - 51

SP - 793

EP - 803

JO - Nature Genetics

JF - Nature Genetics

SN - 1061-4036

IS - 5

ER -