Department of Economics and Business Economics

Genome-wide association study identifies 143 loci associated with 25 hydroxyvitamin D concentration

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  • Joana A. Revez, The University of Queensland
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  • Tian Lin, The University of Queensland
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  • Zhen Qiao, The University of Queensland
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  • Angli Xue, The University of Queensland
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  • Yan Holtz, The University of Queensland
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  • Zhihong Zhu, The University of Queensland
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  • Jian Zeng, The University of Queensland
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  • Huanwei Wang, The University of Queensland
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  • Julia Sidorenko, The University of Queensland
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  • Kathryn E. Kemper, The University of Queensland
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  • Anna A.E. Vinkhuyzen, The University of Queensland
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  • Julanne Frater, The University of Queensland
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  • Darryl Eyles, The University of Queensland, Park Centre for Mental Health
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  • Thomas H.J. Burne, The University of Queensland, Park Centre for Mental Health
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  • Brittany Mitchell, Queensland University of Technology, QIMR Berghofer Medical Research Institute
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  • Nicholas G. Martin, QIMR Berghofer Medical Research Institute
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  • Gu Zhu, QIMR Berghofer Medical Research Institute
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  • Peter M. Visscher, The University of Queensland
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  • Jian Yang, The University of Queensland, Wenzhou Medical University
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  • Naomi R. Wray, The University of Queensland
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  • John J. McGrath

Vitamin D deficiency is a candidate risk factor for a range of adverse health outcomes. In a genome-wide association study of 25 hydroxyvitamin D (25OHD) concentration in 417,580 Europeans we identify 143 independent loci in 112 1-Mb regions, providing insights into the physiology of vitamin D and implicating genes involved in lipid and lipoprotein metabolism, dermal tissue properties, and the sulphonation and glucuronidation of 25OHD. Mendelian randomization models find no robust evidence that 25OHD concentration has causal effects on candidate phenotypes (e.g. BMI, psychiatric disorders), but many phenotypes have (direct or indirect) causal effects on 25OHD concentration, clarifying the epidemiological relationship between 25OHD status and the health outcomes examined in this study.

Original languageEnglish
Article number1647
JournalNature Communications
Volume11
Issue1
Number of pages12
ISSN2041-1723
DOIs
Publication statusPublished - Apr 2020

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