Genome‐wide association for milk production and lactation curve parameters in Holstein dairy cows

TY - JOUR

T1 - Genome‐wide association for milk production and lactation curve parameters in Holstein dairy cows

AU - Atashi, Hadi

AU - Salavati, Mazdak

AU - De Koster, Jenne

AU - Ehrlich, Jim

AU - Crowe, Mark

AU - Opsomer, Gert

AU - GplusE Consortium

AU - Hostens, Miel

AU - Foldager, Leslie

AU - Larsen, Torben

AU - Rousing, Tine

AU - Ettema, Jehan

AU - Østergaard, Søren

AU - Sørensen, Martin Tang

AU - Ingvartsen, Klaus Lønne

N1 - © 2019 The Authors. Journal of Animal Breeding and Genetics published by Blackwell Verlag GmbH.

PY - 2020/5

Y1 - 2020/5

N2 - The aim of this study was to identify genomic regions associated with 305‐day milk yield and lactation curve parameters on primiparous (n = 9,910) and multiparous (n = 11,158) Holstein cows. The SNP solutions were estimated using a weighted single‐step genomic BLUP approach and imputed high‐density panel (777k) genotypes. The proportion of genetic variance explained by windows of 50 consecutive SNP (with an average of 165 Kb) was calculated, and regions that accounted for more than 0.50% of the variance were used to search for candidate genes. Estimated heritabilities were 0.37, 0.34, 0.17, 0.12, 0.30 and 0.19, respectively, for 305‐day milk yield, peak yield, peak time, ramp, scale and decay for primiparous cows. Genetic correlations of 305‐day milk yield with peak yield, peak time, ramp, scale and decay in primiparous cows were 0.99, 0.63, 0.20, 0.97 and −0.52, respectively. The results identified three windows on BTA14 associated with 305‐day milk yield and the parameters of lactation curve in primi‐ and multiparous cows. Previously proposed candidate genes for milk yield supported by this work include GRINA, CYHR1, FOXH1, TONSL, PPP1R16A, ARHGAP39, MAF1, OPLAH and MROH1, whereas newly identified candidate genes are MIR2308, ZNF7, ZNF34, SLURP1, MAFA and KIFC2 (BTA14). The protein lipidation biological process term, which plays a key role in controlling protein localization and function, was identified as the most important term enriched by the identified genes.

AB - The aim of this study was to identify genomic regions associated with 305‐day milk yield and lactation curve parameters on primiparous (n = 9,910) and multiparous (n = 11,158) Holstein cows. The SNP solutions were estimated using a weighted single‐step genomic BLUP approach and imputed high‐density panel (777k) genotypes. The proportion of genetic variance explained by windows of 50 consecutive SNP (with an average of 165 Kb) was calculated, and regions that accounted for more than 0.50% of the variance were used to search for candidate genes. Estimated heritabilities were 0.37, 0.34, 0.17, 0.12, 0.30 and 0.19, respectively, for 305‐day milk yield, peak yield, peak time, ramp, scale and decay for primiparous cows. Genetic correlations of 305‐day milk yield with peak yield, peak time, ramp, scale and decay in primiparous cows were 0.99, 0.63, 0.20, 0.97 and −0.52, respectively. The results identified three windows on BTA14 associated with 305‐day milk yield and the parameters of lactation curve in primi‐ and multiparous cows. Previously proposed candidate genes for milk yield supported by this work include GRINA, CYHR1, FOXH1, TONSL, PPP1R16A, ARHGAP39, MAF1, OPLAH and MROH1, whereas newly identified candidate genes are MIR2308, ZNF7, ZNF34, SLURP1, MAFA and KIFC2 (BTA14). The protein lipidation biological process term, which plays a key role in controlling protein localization and function, was identified as the most important term enriched by the identified genes.

KW - genome-wide association study

KW - Holstein

KW - lactation curve

KW - milk yield

U2 - 10.1111/jbg.12442

DO - 10.1111/jbg.12442

M3 - Journal article

C2 - 31576624

SN - 0931-2668

VL - 137

SP - 292

EP - 304

JO - Journal of Animal Breeding and Genetics

JF - Journal of Animal Breeding and Genetics

IS - 3

ER -