Genome-wide association study of school grades identifies genetic overlap between language ability, psychopathology and creativity

Veera M Rajagopal; Andrea Ganna; Jonathan R I Coleman; Andrea Allegrini; Georgios Voloudakis; Jakob Grove; Thomas D Als; Henriette T Horsdal; Liselotte Petersen; Vivek Appadurai; Andrew Schork; Alfonso Buil; Cynthia M Bulik; Jonas Bybjerg-Grauholm; Marie Bækvad-Hansen; David M Hougaard; Ole Mors; Merete Nordentoft; Thomas Werge; iPSYCH-Broad Consortium; Preben Bo Mortensen; Gerome Breen; Panos Roussos; Robert Plomin; Esben Agerbo; Anders D Børglum; Ditte Demontis

doi:10.1038/s41598-022-26845-0

Genome-wide association study of school grades identifies genetic overlap between language ability, psychopathology and creativity

Veera M Rajagopal^*, Andrea Ganna, Jonathan R I Coleman, Andrea Allegrini, Georgios Voloudakis, Jakob Grove, Thomas D Als, Henriette T Horsdal, Liselotte Petersen, Vivek Appadurai, Andrew Schork, Alfonso Buil, Cynthia M Bulik, Jonas Bybjerg-Grauholm, Marie Bækvad-Hansen, David M Hougaard, Ole Mors, Merete Nordentoft, Thomas Werge, iPSYCH-Broad ConsortiumPreben Bo Mortensen, Gerome Breen, Panos Roussos, Robert Plomin, Esben Agerbo, Anders D Børglum, Ditte Demontis^*

^*Corresponding author for this work

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

12 Citations (Scopus)

Abstract

Cognitive functions of individuals with psychiatric disorders differ from that of the general population. Such cognitive differences often manifest early in life as differential school performance and have a strong genetic basis. Here we measured genetic predictors of school performance in 30,982 individuals in English, Danish and mathematics via a genome-wide association study (GWAS) and studied their relationship with risk for six major psychiatric disorders. When decomposing the school performance into math and language-specific performances, we observed phenotypically and genetically a strong negative correlation between math performance and risk for most psychiatric disorders. But language performance correlated positively with risk for certain disorders, especially schizophrenia, which we replicate in an independent sample (n = 4547). We also found that the genetic variants relating to increased risk for schizophrenia and better language performance are overrepresented in individuals involved in creative professions (n = 2953) compared to the general population (n = 164,622). The findings together suggest that language ability, creativity and psychopathology might stem from overlapping genetic roots.

Original language	English
Article number	429
Journal	Scientific Reports
Volume	13
ISSN	2045-2322
DOIs	https://doi.org/10.1038/s41598-022-26845-0
Publication status	Published - Jan 2023

Keywords

Cognition
Creativity
Genome-Wide Association Study
Humans
Language
Mental Disorders/epidemiology

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Rajagopal, V. M., Ganna, A., Coleman, J. R. I., Allegrini, A., Voloudakis, G., Grove, J., Als, T. D., Horsdal, H. T., Petersen, L., Appadurai, V., Schork, A., Buil, A., Bulik, C. M., Bybjerg-Grauholm, J., Bækvad-Hansen, M., Hougaard, D. M., Mors, O., Nordentoft, M., Werge, T., ... Demontis, D. (2023). Genome-wide association study of school grades identifies genetic overlap between language ability, psychopathology and creativity. Scientific Reports, 13, Article 429. https://doi.org/10.1038/s41598-022-26845-0

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title = "Genome-wide association study of school grades identifies genetic overlap between language ability, psychopathology and creativity",

abstract = "Cognitive functions of individuals with psychiatric disorders differ from that of the general population. Such cognitive differences often manifest early in life as differential school performance and have a strong genetic basis. Here we measured genetic predictors of school performance in 30,982 individuals in English, Danish and mathematics via a genome-wide association study (GWAS) and studied their relationship with risk for six major psychiatric disorders. When decomposing the school performance into math and language-specific performances, we observed phenotypically and genetically a strong negative correlation between math performance and risk for most psychiatric disorders. But language performance correlated positively with risk for certain disorders, especially schizophrenia, which we replicate in an independent sample (n = 4547). We also found that the genetic variants relating to increased risk for schizophrenia and better language performance are overrepresented in individuals involved in creative professions (n = 2953) compared to the general population (n = 164,622). The findings together suggest that language ability, creativity and psychopathology might stem from overlapping genetic roots.",

keywords = "Cognition, Creativity, Genome-Wide Association Study, Humans, Language, Mental Disorders/epidemiology",

author = "Rajagopal, {Veera M} and Andrea Ganna and Coleman, {Jonathan R I} and Andrea Allegrini and Georgios Voloudakis and Jakob Grove and Als, {Thomas D} and Horsdal, {Henriette T} and Liselotte Petersen and Vivek Appadurai and Andrew Schork and Alfonso Buil and Bulik, {Cynthia M} and Jonas Bybjerg-Grauholm and Marie B{\ae}kvad-Hansen and Hougaard, {David M} and Ole Mors and Merete Nordentoft and Thomas Werge and {iPSYCH-Broad Consortium} and Mortensen, {Preben Bo} and Gerome Breen and Panos Roussos and Robert Plomin and Esben Agerbo and B{\o}rglum, {Anders D} and Ditte Demontis",

note = "{\textcopyright} 2023. The Author(s).",

year = "2023",

month = jan,

doi = "10.1038/s41598-022-26845-0",

language = "English",

volume = "13",

journal = "Scientific Reports",

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Rajagopal, VM, Ganna, A, Coleman, JRI, Allegrini, A, Voloudakis, G, Grove, J , Als, TD , Horsdal, HT , Petersen, L, Appadurai, V, Schork, A, Buil, A, Bulik, CM, Bybjerg-Grauholm, J, Bækvad-Hansen, M, Hougaard, DM, Mors, O, Nordentoft, M, Werge, T, iPSYCH-Broad Consortium, Mortensen, PB, Breen, G, Roussos, P, Plomin, R, Agerbo, E , Børglum, AD & Demontis, D 2023, 'Genome-wide association study of school grades identifies genetic overlap between language ability, psychopathology and creativity', Scientific Reports, vol. 13, 429. https://doi.org/10.1038/s41598-022-26845-0

Genome-wide association study of school grades identifies genetic overlap between language ability, psychopathology and creativity. / Rajagopal, Veera M; Ganna, Andrea; Coleman, Jonathan R I et al.
In: Scientific Reports, Vol. 13, 429, 01.2023.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

TY - JOUR

T1 - Genome-wide association study of school grades identifies genetic overlap between language ability, psychopathology and creativity

AU - Rajagopal, Veera M

AU - Ganna, Andrea

AU - Coleman, Jonathan R I

AU - Allegrini, Andrea

AU - Voloudakis, Georgios

AU - Grove, Jakob

AU - Als, Thomas D

AU - Horsdal, Henriette T

AU - Petersen, Liselotte

AU - Appadurai, Vivek

AU - Schork, Andrew

AU - Buil, Alfonso

AU - Bulik, Cynthia M

AU - Bybjerg-Grauholm, Jonas

AU - Bækvad-Hansen, Marie

AU - Hougaard, David M

AU - Mors, Ole

AU - Nordentoft, Merete

AU - Werge, Thomas

AU - iPSYCH-Broad Consortium

AU - Mortensen, Preben Bo

AU - Breen, Gerome

AU - Roussos, Panos

AU - Plomin, Robert

AU - Agerbo, Esben

AU - Børglum, Anders D

AU - Demontis, Ditte

PY - 2023/1

Y1 - 2023/1

N2 - Cognitive functions of individuals with psychiatric disorders differ from that of the general population. Such cognitive differences often manifest early in life as differential school performance and have a strong genetic basis. Here we measured genetic predictors of school performance in 30,982 individuals in English, Danish and mathematics via a genome-wide association study (GWAS) and studied their relationship with risk for six major psychiatric disorders. When decomposing the school performance into math and language-specific performances, we observed phenotypically and genetically a strong negative correlation between math performance and risk for most psychiatric disorders. But language performance correlated positively with risk for certain disorders, especially schizophrenia, which we replicate in an independent sample (n = 4547). We also found that the genetic variants relating to increased risk for schizophrenia and better language performance are overrepresented in individuals involved in creative professions (n = 2953) compared to the general population (n = 164,622). The findings together suggest that language ability, creativity and psychopathology might stem from overlapping genetic roots.

AB - Cognitive functions of individuals with psychiatric disorders differ from that of the general population. Such cognitive differences often manifest early in life as differential school performance and have a strong genetic basis. Here we measured genetic predictors of school performance in 30,982 individuals in English, Danish and mathematics via a genome-wide association study (GWAS) and studied their relationship with risk for six major psychiatric disorders. When decomposing the school performance into math and language-specific performances, we observed phenotypically and genetically a strong negative correlation between math performance and risk for most psychiatric disorders. But language performance correlated positively with risk for certain disorders, especially schizophrenia, which we replicate in an independent sample (n = 4547). We also found that the genetic variants relating to increased risk for schizophrenia and better language performance are overrepresented in individuals involved in creative professions (n = 2953) compared to the general population (n = 164,622). The findings together suggest that language ability, creativity and psychopathology might stem from overlapping genetic roots.

KW - Cognition

KW - Creativity

KW - Genome-Wide Association Study

KW - Humans

KW - Language

KW - Mental Disorders/epidemiology

U2 - 10.1038/s41598-022-26845-0

DO - 10.1038/s41598-022-26845-0

M3 - Journal article

C2 - 36624241

SN - 2045-2322

VL - 13

JO - Scientific Reports

JF - Scientific Reports

M1 - 429

ER -

Genome-wide association study of school grades identifies genetic overlap between language ability, psychopathology and creativity

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