Genome-wide association study identifies loci linked to serum electrolyte traits in Chinese Holstein cattle

Q. F. Gan; Y. R. Li; M. Lund; G. S. Su; X. W. Liang

doi:10.1111/age.12851

Genome-wide association study identifies loci linked to serum electrolyte traits in Chinese Holstein cattle

Q. F. Gan, Y. R. Li, M. Lund, G. S. Su, X. W. Liang^*

^*Corresponding author for this work

Center for Quantitative Genetics and Genomics

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

3 Citations (Scopus)

Abstract

We aimed to identify QTL for serum electrolyte traits by performing a GWAS of calcium, chloride, sodium, potassium and magnesium ion concentrations in Chinese Holstein cattle. We detected five SNPs that had significant associations with calcium ion concentrations and identified GATA2 from Bos taurus chromosome (BTA)22 as having the highest significance. Among the genes with significant results, we speculate that TMEM123 might be related to calcium channel proteins according to the functions of the TMEM family.

Original language	English
Journal	Animal Genetics
Volume	50
Issue	6
Pages (from-to)	744-748
Number of pages	5
ISSN	0268-9146
DOIs	https://doi.org/10.1111/age.12851
Publication status	Published - Dec 2019

Keywords

Calcium ions
Chloride ion
Dairy cattle
FarmCPU
GATA2

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title = "Genome-wide association study identifies loci linked to serum electrolyte traits in Chinese Holstein cattle",

abstract = "We aimed to identify QTL for serum electrolyte traits by performing a GWAS of calcium, chloride, sodium, potassium and magnesium ion concentrations in Chinese Holstein cattle. We detected five SNPs that had significant associations with calcium ion concentrations and identified GATA2 from Bos taurus chromosome (BTA)22 as having the highest significance. Among the genes with significant results, we speculate that TMEM123 might be related to calcium channel proteins according to the functions of the TMEM family.",

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AU - Gan, Q. F.

AU - Li, Y. R.

AU - Lund, M.

AU - Su, G. S.

AU - Liang, X. W.

PY - 2019/12

Y1 - 2019/12

N2 - We aimed to identify QTL for serum electrolyte traits by performing a GWAS of calcium, chloride, sodium, potassium and magnesium ion concentrations in Chinese Holstein cattle. We detected five SNPs that had significant associations with calcium ion concentrations and identified GATA2 from Bos taurus chromosome (BTA)22 as having the highest significance. Among the genes with significant results, we speculate that TMEM123 might be related to calcium channel proteins according to the functions of the TMEM family.

AB - We aimed to identify QTL for serum electrolyte traits by performing a GWAS of calcium, chloride, sodium, potassium and magnesium ion concentrations in Chinese Holstein cattle. We detected five SNPs that had significant associations with calcium ion concentrations and identified GATA2 from Bos taurus chromosome (BTA)22 as having the highest significance. Among the genes with significant results, we speculate that TMEM123 might be related to calcium channel proteins according to the functions of the TMEM family.

KW - Calcium ions

KW - Chloride ion

KW - Dairy cattle

KW - FarmCPU

KW - GATA2

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JF - Animal Genetics

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ER -

Genome-wide association study identifies loci linked to serum electrolyte traits in Chinese Holstein cattle

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Keywords

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