Genome-wide association studies revealed candidate genes for tail fat deposition and body size in the Hulun Buir sheep

Tongyu Zhang; Hongding Gao; Goutam Sahana; Yanjun Zan; Hongying Fan; Jiaxin Liu; Liangyu Shi; Jiqiang Liu; Lixin Du; Lixian Wang; Fuping Zhao

doi:10.1111/jbg.12402

Genome-wide association studies revealed candidate genes for tail fat deposition and body size in the Hulun Buir sheep

Tongyu Zhang, Hongding Gao, Goutam Sahana, Yanjun Zan, Hongying Fan, Jiaxin Liu, Liangyu Shi, Jiqiang Liu, Lixin Du, Lixian Wang^*, Fuping Zhao

^*Corresponding author for this work

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

40 Citations (Scopus)

Abstract

Fat-tailed sheep have a unique characteristic of depositing fat in their tails. In the present study, we conducted genome-wide association studies (GWAS) on traits related to tail fat deposition and body size in the Hulun Buir sheep. A total number of 300 individuals belonging to two fat-tailed lines of the Hulun Buir sheep breed genotyped with the Ovine Infinium HD SNP BeadChip were included in the current study. Two mixed models, one for continuous and one for binary phenotypic traits, were employed to analyse ten traits, that is, body length (BL), body height (BH), chest girth (CG), tail length (TL), tail width (TW), tail circumference (TC), carcass weight (CW), tail fat weight (TF), ratio of CW to TF (RCT) and tail type (TT). We identified 7, 6, 7, 2, 10 and 1 SNPs significantly associated with traits TF, CW, RCT, TW, TT and CG, respectively. Their associated genomic regions harboured 42 positional candidate genes. Out of them, 13 candidate genes including SMURF2, FBF1, DTNBP1, SETD7 and RBM11 have been associated with fat metabolism in sheep. The RBM11 gene has already been identified in a previous study on signatures of selection in this specific sheep population. Two more genes, that is, SMARCA5 and GAB1 were associated with body size in sheep. The present study has identified candidate genes that might be implicated in tail fat deposition and body size in sheep.

Original language	English
Journal	Journal of Animal Breeding and Genetics
Volume	136
Issue	5
Pages (from-to)	362-370
Number of pages	9
ISSN	0931-2668
DOIs	https://doi.org/10.1111/jbg.12402
Publication status	Published - Sept 2019

Keywords

candidate genes
fat deposition
genome-wide association study
Hulun Buir sheep
tail type

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10.1111/jbg.12402

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@article{e6ab6eebfbe34c09a6ab86dcd519732f,

title = "Genome-wide association studies revealed candidate genes for tail fat deposition and body size in the Hulun Buir sheep",

abstract = "Fat-tailed sheep have a unique characteristic of depositing fat in their tails. In the present study, we conducted genome-wide association studies (GWAS) on traits related to tail fat deposition and body size in the Hulun Buir sheep. A total number of 300 individuals belonging to two fat-tailed lines of the Hulun Buir sheep breed genotyped with the Ovine Infinium HD SNP BeadChip were included in the current study. Two mixed models, one for continuous and one for binary phenotypic traits, were employed to analyse ten traits, that is, body length (BL), body height (BH), chest girth (CG), tail length (TL), tail width (TW), tail circumference (TC), carcass weight (CW), tail fat weight (TF), ratio of CW to TF (RCT) and tail type (TT). We identified 7, 6, 7, 2, 10 and 1 SNPs significantly associated with traits TF, CW, RCT, TW, TT and CG, respectively. Their associated genomic regions harboured 42 positional candidate genes. Out of them, 13 candidate genes including SMURF2, FBF1, DTNBP1, SETD7 and RBM11 have been associated with fat metabolism in sheep. The RBM11 gene has already been identified in a previous study on signatures of selection in this specific sheep population. Two more genes, that is, SMARCA5 and GAB1 were associated with body size in sheep. The present study has identified candidate genes that might be implicated in tail fat deposition and body size in sheep.",

keywords = "candidate genes, fat deposition, genome-wide association study, Hulun Buir sheep, tail type",

author = "Tongyu Zhang and Hongding Gao and Goutam Sahana and Yanjun Zan and Hongying Fan and Jiaxin Liu and Liangyu Shi and Jiqiang Liu and Lixin Du and Lixian Wang and Fuping Zhao",

year = "2019",

month = sep,

doi = "10.1111/jbg.12402",

language = "English",

volume = "136",

pages = "362--370",

journal = "Journal of Animal Breeding and Genetics",

issn = "0931-2668",

publisher = "Wiley-Blackwell",

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}

Genome-wide association studies revealed candidate genes for tail fat deposition and body size in the Hulun Buir sheep. / Zhang, Tongyu; Gao, Hongding; Sahana, Goutam et al.
In: Journal of Animal Breeding and Genetics, Vol. 136, No. 5, 09.2019, p. 362-370.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

TY - JOUR

T1 - Genome-wide association studies revealed candidate genes for tail fat deposition and body size in the Hulun Buir sheep

AU - Zhang, Tongyu

AU - Gao, Hongding

AU - Sahana, Goutam

AU - Zan, Yanjun

AU - Fan, Hongying

AU - Liu, Jiaxin

AU - Shi, Liangyu

AU - Liu, Jiqiang

AU - Du, Lixin

AU - Wang, Lixian

AU - Zhao, Fuping

PY - 2019/9

Y1 - 2019/9

N2 - Fat-tailed sheep have a unique characteristic of depositing fat in their tails. In the present study, we conducted genome-wide association studies (GWAS) on traits related to tail fat deposition and body size in the Hulun Buir sheep. A total number of 300 individuals belonging to two fat-tailed lines of the Hulun Buir sheep breed genotyped with the Ovine Infinium HD SNP BeadChip were included in the current study. Two mixed models, one for continuous and one for binary phenotypic traits, were employed to analyse ten traits, that is, body length (BL), body height (BH), chest girth (CG), tail length (TL), tail width (TW), tail circumference (TC), carcass weight (CW), tail fat weight (TF), ratio of CW to TF (RCT) and tail type (TT). We identified 7, 6, 7, 2, 10 and 1 SNPs significantly associated with traits TF, CW, RCT, TW, TT and CG, respectively. Their associated genomic regions harboured 42 positional candidate genes. Out of them, 13 candidate genes including SMURF2, FBF1, DTNBP1, SETD7 and RBM11 have been associated with fat metabolism in sheep. The RBM11 gene has already been identified in a previous study on signatures of selection in this specific sheep population. Two more genes, that is, SMARCA5 and GAB1 were associated with body size in sheep. The present study has identified candidate genes that might be implicated in tail fat deposition and body size in sheep.

AB - Fat-tailed sheep have a unique characteristic of depositing fat in their tails. In the present study, we conducted genome-wide association studies (GWAS) on traits related to tail fat deposition and body size in the Hulun Buir sheep. A total number of 300 individuals belonging to two fat-tailed lines of the Hulun Buir sheep breed genotyped with the Ovine Infinium HD SNP BeadChip were included in the current study. Two mixed models, one for continuous and one for binary phenotypic traits, were employed to analyse ten traits, that is, body length (BL), body height (BH), chest girth (CG), tail length (TL), tail width (TW), tail circumference (TC), carcass weight (CW), tail fat weight (TF), ratio of CW to TF (RCT) and tail type (TT). We identified 7, 6, 7, 2, 10 and 1 SNPs significantly associated with traits TF, CW, RCT, TW, TT and CG, respectively. Their associated genomic regions harboured 42 positional candidate genes. Out of them, 13 candidate genes including SMURF2, FBF1, DTNBP1, SETD7 and RBM11 have been associated with fat metabolism in sheep. The RBM11 gene has already been identified in a previous study on signatures of selection in this specific sheep population. Two more genes, that is, SMARCA5 and GAB1 were associated with body size in sheep. The present study has identified candidate genes that might be implicated in tail fat deposition and body size in sheep.

KW - candidate genes

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KW - genome-wide association study

KW - Hulun Buir sheep

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U2 - 10.1111/jbg.12402

DO - 10.1111/jbg.12402

M3 - Journal article

C2 - 31045295

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SN - 0931-2668

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SP - 362

EP - 370

JO - Journal of Animal Breeding and Genetics

JF - Journal of Animal Breeding and Genetics

IS - 5

ER -

Genome-wide association studies revealed candidate genes for tail fat deposition and body size in the Hulun Buir sheep

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Keywords

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