Genome-wide and local pattern of linkage disequilibrium and persistence of phase for 3 Danish pig breeds

TY - JOUR

T1 - Genome-wide and local pattern of linkage disequilibrium and persistence of phase for 3 Danish pig breeds

AU - Wang, Lei

AU - Sørensen, Peter

AU - Janss, Luc

AU - Ostersen, Tage

AU - Edwards, David

PY - 2013/12/5

Y1 - 2013/12/5

N2 - The extent of linkage disequilibrium (LD) is of critical importance for genomic selection and marker assisted selection. The primary purpose of this study is to examine patterns of LD in three Danish pig breeds (Duroc, Landrace and Yorkshire); we also examine patterns of persistence of phase between the breeds. We quantify local LD by fitting a model relating LD to physical distance between markers in sliding windows, and use this to visualize how LD varies according to physical position. We use a similar method to examine local persistence of phase.

AB - The extent of linkage disequilibrium (LD) is of critical importance for genomic selection and marker assisted selection. The primary purpose of this study is to examine patterns of LD in three Danish pig breeds (Duroc, Landrace and Yorkshire); we also examine patterns of persistence of phase between the breeds. We quantify local LD by fitting a model relating LD to physical distance between markers in sliding windows, and use this to visualize how LD varies according to physical position. We use a similar method to examine local persistence of phase.

KW - Linkage disequilibrium

KW - Persistence of phase

KW - Danish pig breeds

KW - Model local LD

KW - Visualize local LD variation

U2 - 10.1186/1471-2156-14-115

DO - 10.1186/1471-2156-14-115

M3 - Journal article

C2 - 24304600

SN - 1471-2156

VL - 14

JO - BMC Genetics

JF - BMC Genetics

IS - 115

ER -