Genome Scan Detects Quantitative Trait Loci Affecting Female Fertility Traits in Danish and Swedish Holstein Cattle

Johanna Karolina Höglund; B Guldbrandtsen; G Su; B Thomsen; M S Lund

doi:10.3168/jds.2008-1104

Genome Scan Detects Quantitative Trait Loci Affecting Female Fertility Traits in Danish and Swedish Holstein Cattle

Johanna Karolina Höglund, B Guldbrandtsen, G Su, B Thomsen, M S Lund

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

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Abstract

Data from the joint Nordic breeding value prediction for Danishand Swedish Holstein grandsire families were used to locatequantitative trait loci (QTL) for female fertility traits inDanish and Swedish Holstein cattle. Up to 36 Holstein grandsireswith over 2,000 sons were genotyped for 416 microsatellite markers.Single trait breeding values were used for 12 traits relatingto female fertility and female reproductive disorders. Datawere analyzed by least squares regression analysis within andacross families. Twenty-six QTL were detected on 17 differentchromosomes. The best evidence was found for QTL segregatingon Bos taurus chromosome (BTA)1, BTA7, BTA10, and BTA26. Oneach of these chromosomes, several QTL were detected affectingmore than one of the fertility traits investigated in this study.Evidence for segregation of additional QTL on BTA2, BTA9, andBTA24 was found

Original language	English
Journal	Journal of Dairy Science
Issue	92
Pages (from-to)	2136-2143
ISSN	0022-0302
DOIs	https://doi.org/10.3168/jds.2008-1104
Publication status	Published - 2009

Keywords

quantitative trait locus
genome-wide scan
female fertility

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Journal of Dairy Science 92Final published version, 628 KB

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@article{b569c5a0fa8311dc8e62000ea68e967b,

title = "Genome Scan Detects Quantitative Trait Loci Affecting Female Fertility Traits in Danish and Swedish Holstein Cattle",

abstract = "Data from the joint Nordic breeding value prediction for Danish and Swedish Holstein grandsire families were used to locate quantitative trait loci (QTL) for female fertility traits in Danish and Swedish Holstein cattle. Up to 36 Holstein grandsires with over 2,000 sons were genotyped for 416 microsatellite markers. Single trait breeding values were used for 12 traits relating to female fertility and female reproductive disorders. Data were analyzed by least squares regression analysis within and across families. Twenty-six QTL were detected on 17 different chromosomes. The best evidence was found for QTL segregating on Bos taurus chromosome (BTA)1, BTA7, BTA10, and BTA26. On each of these chromosomes, several QTL were detected affecting more than one of the fertility traits investigated in this study. Evidence for segregation of additional QTL on BTA2, BTA9, and BTA24 was found",

keywords = "quantitative trait locus, genome-wide scan, female fertility",

author = "H{\"o}glund, {Johanna Karolina} and B Guldbrandtsen and G Su and B Thomsen and Lund, {M S}",

year = "2009",

doi = "10.3168/jds.2008-1104",

language = "English",

pages = "2136--2143",

journal = "Journal of Dairy Science",

issn = "0022-0302",

publisher = "Elsevier Inc.",

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Genome Scan Detects Quantitative Trait Loci Affecting Female Fertility Traits in Danish and Swedish Holstein Cattle. / Höglund, Johanna Karolina; Guldbrandtsen, B; Su, G et al.
In: Journal of Dairy Science, No. 92, 2009, p. 2136-2143.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

TY - JOUR

T1 - Genome Scan Detects Quantitative Trait Loci Affecting Female Fertility Traits in Danish and Swedish Holstein Cattle

AU - Höglund, Johanna Karolina

AU - Guldbrandtsen, B

AU - Su, G

AU - Thomsen, B

AU - Lund, M S

PY - 2009

Y1 - 2009

N2 - Data from the joint Nordic breeding value prediction for Danish and Swedish Holstein grandsire families were used to locate quantitative trait loci (QTL) for female fertility traits in Danish and Swedish Holstein cattle. Up to 36 Holstein grandsires with over 2,000 sons were genotyped for 416 microsatellite markers. Single trait breeding values were used for 12 traits relating to female fertility and female reproductive disorders. Data were analyzed by least squares regression analysis within and across families. Twenty-six QTL were detected on 17 different chromosomes. The best evidence was found for QTL segregating on Bos taurus chromosome (BTA)1, BTA7, BTA10, and BTA26. On each of these chromosomes, several QTL were detected affecting more than one of the fertility traits investigated in this study. Evidence for segregation of additional QTL on BTA2, BTA9, and BTA24 was found

AB - Data from the joint Nordic breeding value prediction for Danish and Swedish Holstein grandsire families were used to locate quantitative trait loci (QTL) for female fertility traits in Danish and Swedish Holstein cattle. Up to 36 Holstein grandsires with over 2,000 sons were genotyped for 416 microsatellite markers. Single trait breeding values were used for 12 traits relating to female fertility and female reproductive disorders. Data were analyzed by least squares regression analysis within and across families. Twenty-six QTL were detected on 17 different chromosomes. The best evidence was found for QTL segregating on Bos taurus chromosome (BTA)1, BTA7, BTA10, and BTA26. On each of these chromosomes, several QTL were detected affecting more than one of the fertility traits investigated in this study. Evidence for segregation of additional QTL on BTA2, BTA9, and BTA24 was found

KW - quantitative trait locus

KW - genome-wide scan

KW - female fertility

U2 - 10.3168/jds.2008-1104

DO - 10.3168/jds.2008-1104

M3 - Journal article

C2 - 19389971

SN - 0022-0302

SP - 2136

EP - 2143

JO - Journal of Dairy Science

JF - Journal of Dairy Science

IS - 92

ER -

Genome Scan Detects Quantitative Trait Loci Affecting Female Fertility Traits in Danish and Swedish Holstein Cattle

Abstract

Keywords

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