Genetic Susceptibility for Childhood BMI has no Impact on Weight Loss Following Lifestyle Intervention in Danish Children

Mette Fogh; Mette Hollensted; Theresia M Schnurr; Julie T Kloppenborg; Christian T Have; Tenna Ruest Haarmark Nielsen; Johanne Rask; Morten Asp Vonsild Lund; Christine Frithioff-Bøjsøe; Mia Østergaard Johansen; Emil Vincent Rosenbaum Appel; Yuvaraj Mahendran; Niels Grarup; Haja N Kadarmideen; Oluf Pedersen; Jens-Christian Holm; Torben Hansen

doi:10.1002/oby.22308

Genetic Susceptibility for Childhood BMI has no Impact on Weight Loss Following Lifestyle Intervention in Danish Children

Mette Fogh, Mette Hollensted, Theresia M Schnurr, Julie T Kloppenborg, Christian T Have, Tenna Ruest Haarmark Nielsen, Johanne Rask, Morten Asp Vonsild Lund, Christine Frithioff-Bøjsøe, Mia Østergaard Johansen, Emil Vincent Rosenbaum Appel, Yuvaraj Mahendran, Niels Grarup, Haja N Kadarmideen, Oluf Pedersen, Jens-Christian Holm, Torben Hansen

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

Abstract

OBJECTIVE: This study aimed to investigate the effect of a genetic risk score (GRS) comprising 15 single-nucleotide polymorphisms, previously shown to associate with childhood BMI, on the baseline cardiometabolic traits and the response to a lifestyle intervention in Danish children and adolescents.

METHODS: Children and adolescents with overweight or obesity (n = 920) and a population-based control sample (n = 698) were recruited. Anthropometric and biochemical measures were obtained at baseline and in a subgroup of children and adolescents with overweight or obesity again after 6 to 24 months of lifestyle intervention (n = 754). The effects of the GRS were examined by multiple linear regressions using additive genetic models.

RESULTS: At baseline, the GRS associated with BMI standard deviation score (SDS) both in children and adolescents with overweight or obesity (β = 0.033 [SE = 0.01]; P = 0.001) and in the population-based sample (β = 0.065 [SE = 0.02]; P = 0.001). No associations were observed for cardiometabolic traits. The GRS did not influence changes in BMI SDS or cardiometabolic traits following lifestyle intervention.

CONCLUSIONS: A GRS for childhood BMI was associated with BMI SDS but not with other cardiometabolic traits in Danish children and adolescents. The GRS did not influence treatment response following lifestyle intervention.

Original language	English
Journal	Obesity
Volume	26
Issue	12
Pages (from-to)	1915-1922
Number of pages	8
ISSN	1930-7381
DOIs	https://doi.org/10.1002/oby.22308
Publication status	Published - Dec 2018
Externally published	Yes

Keywords

Adolescent
Body Mass Index
Child
Denmark
Female
Genetic Predisposition to Disease/genetics
Humans
Life Style
Male
Obesity/therapy
Polymorphism, Single Nucleotide/genetics
Weight Loss/genetics

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10.1002/oby.22308

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Fogh, M., Hollensted, M., Schnurr, T. M., Kloppenborg, J. T., Have, C. T., Ruest Haarmark Nielsen, T., Rask, J., Asp Vonsild Lund, M., Frithioff-Bøjsøe, C., Østergaard Johansen, M., Vincent Rosenbaum Appel, E., Mahendran, Y., Grarup, N., Kadarmideen, H. N., Pedersen, O., Holm, J.-C., & Hansen, T. (2018). Genetic Susceptibility for Childhood BMI has no Impact on Weight Loss Following Lifestyle Intervention in Danish Children. Obesity, 26(12), 1915-1922. https://doi.org/10.1002/oby.22308

@article{468fd24c1187487b83c4c259de604348,

title = "Genetic Susceptibility for Childhood BMI has no Impact on Weight Loss Following Lifestyle Intervention in Danish Children",

abstract = "OBJECTIVE: This study aimed to investigate the effect of a genetic risk score (GRS) comprising 15 single-nucleotide polymorphisms, previously shown to associate with childhood BMI, on the baseline cardiometabolic traits and the response to a lifestyle intervention in Danish children and adolescents.METHODS: Children and adolescents with overweight or obesity (n = 920) and a population-based control sample (n = 698) were recruited. Anthropometric and biochemical measures were obtained at baseline and in a subgroup of children and adolescents with overweight or obesity again after 6 to 24 months of lifestyle intervention (n = 754). The effects of the GRS were examined by multiple linear regressions using additive genetic models.RESULTS: At baseline, the GRS associated with BMI standard deviation score (SDS) both in children and adolescents with overweight or obesity (β = 0.033 [SE = 0.01]; P = 0.001) and in the population-based sample (β = 0.065 [SE = 0.02]; P = 0.001). No associations were observed for cardiometabolic traits. The GRS did not influence changes in BMI SDS or cardiometabolic traits following lifestyle intervention.CONCLUSIONS: A GRS for childhood BMI was associated with BMI SDS but not with other cardiometabolic traits in Danish children and adolescents. The GRS did not influence treatment response following lifestyle intervention.",

keywords = "Adolescent, Body Mass Index, Child, Denmark, Female, Genetic Predisposition to Disease/genetics, Humans, Life Style, Male, Obesity/therapy, Polymorphism, Single Nucleotide/genetics, Weight Loss/genetics",

author = "Mette Fogh and Mette Hollensted and Schnurr, {Theresia M} and Kloppenborg, {Julie T} and Have, {Christian T} and {Ruest Haarmark Nielsen}, Tenna and Johanne Rask and {Asp Vonsild Lund}, Morten and Christine Frithioff-B{\o}js{\o}e and {{\O}stergaard Johansen}, Mia and {Vincent Rosenbaum Appel}, Emil and Yuvaraj Mahendran and Niels Grarup and Kadarmideen, {Haja N} and Oluf Pedersen and Jens-Christian Holm and Torben Hansen",

note = "{\textcopyright} 2018 The Obesity Society.",

year = "2018",

month = dec,

doi = "10.1002/oby.22308",

language = "English",

volume = "26",

pages = "1915--1922",

journal = "Obesity",

issn = "1930-7381",

publisher = "Wiley-Blackwell Publishing, Inc.",

number = "12",

}

Fogh, M, Hollensted, M, Schnurr, TM, Kloppenborg, JT, Have, CT, Ruest Haarmark Nielsen, T, Rask, J, Asp Vonsild Lund, M, Frithioff-Bøjsøe, C, Østergaard Johansen, M, Vincent Rosenbaum Appel, E, Mahendran, Y, Grarup, N, Kadarmideen, HN, Pedersen, O, Holm, J-C & Hansen, T 2018, 'Genetic Susceptibility for Childhood BMI has no Impact on Weight Loss Following Lifestyle Intervention in Danish Children', Obesity, vol. 26, no. 12, pp. 1915-1922. https://doi.org/10.1002/oby.22308

Genetic Susceptibility for Childhood BMI has no Impact on Weight Loss Following Lifestyle Intervention in Danish Children. / Fogh, Mette; Hollensted, Mette; Schnurr, Theresia M et al.
In: Obesity, Vol. 26, No. 12, 12.2018, p. 1915-1922.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

TY - JOUR

T1 - Genetic Susceptibility for Childhood BMI has no Impact on Weight Loss Following Lifestyle Intervention in Danish Children

AU - Fogh, Mette

AU - Hollensted, Mette

AU - Schnurr, Theresia M

AU - Kloppenborg, Julie T

AU - Have, Christian T

AU - Ruest Haarmark Nielsen, Tenna

AU - Rask, Johanne

AU - Asp Vonsild Lund, Morten

AU - Frithioff-Bøjsøe, Christine

AU - Østergaard Johansen, Mia

AU - Vincent Rosenbaum Appel, Emil

AU - Mahendran, Yuvaraj

AU - Grarup, Niels

AU - Kadarmideen, Haja N

AU - Pedersen, Oluf

AU - Holm, Jens-Christian

AU - Hansen, Torben

PY - 2018/12

Y1 - 2018/12

N2 - OBJECTIVE: This study aimed to investigate the effect of a genetic risk score (GRS) comprising 15 single-nucleotide polymorphisms, previously shown to associate with childhood BMI, on the baseline cardiometabolic traits and the response to a lifestyle intervention in Danish children and adolescents.METHODS: Children and adolescents with overweight or obesity (n = 920) and a population-based control sample (n = 698) were recruited. Anthropometric and biochemical measures were obtained at baseline and in a subgroup of children and adolescents with overweight or obesity again after 6 to 24 months of lifestyle intervention (n = 754). The effects of the GRS were examined by multiple linear regressions using additive genetic models.RESULTS: At baseline, the GRS associated with BMI standard deviation score (SDS) both in children and adolescents with overweight or obesity (β = 0.033 [SE = 0.01]; P = 0.001) and in the population-based sample (β = 0.065 [SE = 0.02]; P = 0.001). No associations were observed for cardiometabolic traits. The GRS did not influence changes in BMI SDS or cardiometabolic traits following lifestyle intervention.CONCLUSIONS: A GRS for childhood BMI was associated with BMI SDS but not with other cardiometabolic traits in Danish children and adolescents. The GRS did not influence treatment response following lifestyle intervention.

AB - OBJECTIVE: This study aimed to investigate the effect of a genetic risk score (GRS) comprising 15 single-nucleotide polymorphisms, previously shown to associate with childhood BMI, on the baseline cardiometabolic traits and the response to a lifestyle intervention in Danish children and adolescents.METHODS: Children and adolescents with overweight or obesity (n = 920) and a population-based control sample (n = 698) were recruited. Anthropometric and biochemical measures were obtained at baseline and in a subgroup of children and adolescents with overweight or obesity again after 6 to 24 months of lifestyle intervention (n = 754). The effects of the GRS were examined by multiple linear regressions using additive genetic models.RESULTS: At baseline, the GRS associated with BMI standard deviation score (SDS) both in children and adolescents with overweight or obesity (β = 0.033 [SE = 0.01]; P = 0.001) and in the population-based sample (β = 0.065 [SE = 0.02]; P = 0.001). No associations were observed for cardiometabolic traits. The GRS did not influence changes in BMI SDS or cardiometabolic traits following lifestyle intervention.CONCLUSIONS: A GRS for childhood BMI was associated with BMI SDS but not with other cardiometabolic traits in Danish children and adolescents. The GRS did not influence treatment response following lifestyle intervention.

KW - Adolescent

KW - Body Mass Index

KW - Child

KW - Denmark

KW - Female

KW - Genetic Predisposition to Disease/genetics

KW - Humans

KW - Life Style

KW - Male

KW - Obesity/therapy

KW - Polymorphism, Single Nucleotide/genetics

KW - Weight Loss/genetics

U2 - 10.1002/oby.22308

DO - 10.1002/oby.22308

M3 - Journal article

C2 - 30460774

SN - 1930-7381

VL - 26

SP - 1915

EP - 1922

JO - Obesity

JF - Obesity

IS - 12

ER -

Genetic Susceptibility for Childhood BMI has no Impact on Weight Loss Following Lifestyle Intervention in Danish Children

Abstract

Keywords

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