Department of Economics and Business Economics

Genetic risk for autism spectrum disorders and neuropsychiatric variation in the general population

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  • Elise B Robinson
  • ,
  • Beate St Pourcain
  • ,
  • Verneri Anttila
  • ,
  • Jack A Kosmicki
  • ,
  • Brendan Bulik-Sullivan
  • ,
  • Jakob Grove
  • Julian Maller
  • ,
  • Kaitlin E Samocha
  • ,
  • Stephan J Sanders
  • ,
  • Stephan Ripke
  • ,
  • Joanna Martin
  • ,
  • Mads V Hollegaard
  • ,
  • Thomas Werge
  • ,
  • David M Hougaard
  • ,
  • Benjamin M Neale
  • ,
  • David M Evans
  • ,
  • David Skuse
  • ,
  • Preben Bo Mortensen
  • Anders D Børglum
  • Angelica Ronald
  • ,
  • George Davey Smith
  • ,
  • Mark J Daly
  • ,
  • iPSYCH-SSI-Broad Autism Group
  • ,
  • Thomas Damm Als (Member of author collaboration)

Almost all genetic risk factors for autism spectrum disorders (ASDs) can be found in the general population, but the effects of this risk are unclear in people not ascertained for neuropsychiatric symptoms. Using several large ASD consortium and population-based resources (total n > 38,000), we find genome-wide genetic links between ASDs and typical variation in social behavior and adaptive functioning. This finding is evidenced through both LD score correlation and de novo variant analysis, indicating that multiple types of genetic risk for ASDs influence a continuum of behavioral and developmental traits, the severe tail of which can result in diagnosis with an ASD or other neuropsychiatric disorder. A continuum model should inform the design and interpretation of studies of neuropsychiatric disease biology.

Original languageEnglish
JournalNature Genetics
Volume48
Pages (from-to)552–555
ISSN1061-4036
DOIs
Publication statusPublished - 2016

See relations at Aarhus University Citationformats

ID: 99579037