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Genetic polymorphisms in COMT and BDNF influence synchronization dynamics of human neuronal oscillations

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Genetic polymorphisms in COMT and BDNF influence synchronization dynamics of human neuronal oscillations. / Simola, Jaana; Siebenhühner, Felix; Myrov, Vladislav et al.

In: iScience, Vol. 25, No. 9, 104985, 09.2022.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

Harvard

Simola, J, Siebenhühner, F, Myrov, V, Kantojärvi, K, Paunio, T, Palva, JM, Brattico, E & Palva, S 2022, 'Genetic polymorphisms in COMT and BDNF influence synchronization dynamics of human neuronal oscillations', iScience, vol. 25, no. 9, 104985. https://doi.org/10.1016/j.isci.2022.104985

APA

Simola, J., Siebenhühner, F., Myrov, V., Kantojärvi, K., Paunio, T., Palva, J. M., Brattico, E., & Palva, S. (2022). Genetic polymorphisms in COMT and BDNF influence synchronization dynamics of human neuronal oscillations. iScience, 25(9), [104985]. https://doi.org/10.1016/j.isci.2022.104985

CBE

Simola J, Siebenhühner F, Myrov V, Kantojärvi K, Paunio T, Palva JM, Brattico E, Palva S. 2022. Genetic polymorphisms in COMT and BDNF influence synchronization dynamics of human neuronal oscillations. iScience. 25(9):Article 104985. https://doi.org/10.1016/j.isci.2022.104985

MLA

Simola, Jaana et al. "Genetic polymorphisms in COMT and BDNF influence synchronization dynamics of human neuronal oscillations". iScience. 2022. 25(9). https://doi.org/10.1016/j.isci.2022.104985

Vancouver

Simola J, Siebenhühner F, Myrov V, Kantojärvi K, Paunio T, Palva JM et al. Genetic polymorphisms in COMT and BDNF influence synchronization dynamics of human neuronal oscillations. iScience. 2022 Sep;25(9):104985. doi: 10.1016/j.isci.2022.104985

Author

Simola, Jaana ; Siebenhühner, Felix ; Myrov, Vladislav et al. / Genetic polymorphisms in COMT and BDNF influence synchronization dynamics of human neuronal oscillations. In: iScience. 2022 ; Vol. 25, No. 9.

Bibtex

@article{6c3d432b01ad454987d4e7c7d6024b8d,
title = "Genetic polymorphisms in COMT and BDNF influence synchronization dynamics of human neuronal oscillations",
abstract = "Neuronal oscillations, their inter-areal synchronization, and scale-free dynamics constitute fundamental mechanisms for cognition by regulating communication in neuronal networks. These oscillatory dynamics have large inter-individual variability that is partly heritable. We hypothesized that this variability could be partially explained by genetic polymorphisms in neuromodulatory genes. We recorded resting-state magnetoencephalography (MEG) from 82 healthy participants and investigated whether oscillation dynamics were influenced by genetic polymorphisms in catechol-O-methyltransferase (COMT) Val158Met and brain-derived neurotrophic factor (BDNF) Val66Met. Both COMT and BDNF polymorphisms influenced local oscillation amplitudes and their long-range temporal correlations (LRTCs), while only BDNF polymorphism affected the strength of large-scale synchronization. Our findings demonstrate that COMT and BDNF genetic polymorphisms contribute to inter-individual variability in neuronal oscillation dynamics. Comparison of these results to computational modeling of near-critical synchronization dynamics further suggested that COMT and BDNF polymorphisms influenced local oscillations by modulating the excitation-inhibition balance according to the brain criticality framework.",
keywords = "Biological sciences, Cognitive neuroscience, Neuroscience",
author = "Jaana Simola and Felix Siebenh{\"u}hner and Vladislav Myrov and Katri Kantoj{\"a}rvi and Tiina Paunio and Palva, {J. Matias} and Elvira Brattico and Satu Palva",
note = "Publisher Copyright: {\textcopyright} 2022 The Authors",
year = "2022",
month = sep,
doi = "10.1016/j.isci.2022.104985",
language = "English",
volume = "25",
journal = "iScience",
issn = "2589-0042",
publisher = "Elsevier Inc.",
number = "9",

}

RIS

TY - JOUR

T1 - Genetic polymorphisms in COMT and BDNF influence synchronization dynamics of human neuronal oscillations

AU - Simola, Jaana

AU - Siebenhühner, Felix

AU - Myrov, Vladislav

AU - Kantojärvi, Katri

AU - Paunio, Tiina

AU - Palva, J. Matias

AU - Brattico, Elvira

AU - Palva, Satu

N1 - Publisher Copyright: © 2022 The Authors

PY - 2022/9

Y1 - 2022/9

N2 - Neuronal oscillations, their inter-areal synchronization, and scale-free dynamics constitute fundamental mechanisms for cognition by regulating communication in neuronal networks. These oscillatory dynamics have large inter-individual variability that is partly heritable. We hypothesized that this variability could be partially explained by genetic polymorphisms in neuromodulatory genes. We recorded resting-state magnetoencephalography (MEG) from 82 healthy participants and investigated whether oscillation dynamics were influenced by genetic polymorphisms in catechol-O-methyltransferase (COMT) Val158Met and brain-derived neurotrophic factor (BDNF) Val66Met. Both COMT and BDNF polymorphisms influenced local oscillation amplitudes and their long-range temporal correlations (LRTCs), while only BDNF polymorphism affected the strength of large-scale synchronization. Our findings demonstrate that COMT and BDNF genetic polymorphisms contribute to inter-individual variability in neuronal oscillation dynamics. Comparison of these results to computational modeling of near-critical synchronization dynamics further suggested that COMT and BDNF polymorphisms influenced local oscillations by modulating the excitation-inhibition balance according to the brain criticality framework.

AB - Neuronal oscillations, their inter-areal synchronization, and scale-free dynamics constitute fundamental mechanisms for cognition by regulating communication in neuronal networks. These oscillatory dynamics have large inter-individual variability that is partly heritable. We hypothesized that this variability could be partially explained by genetic polymorphisms in neuromodulatory genes. We recorded resting-state magnetoencephalography (MEG) from 82 healthy participants and investigated whether oscillation dynamics were influenced by genetic polymorphisms in catechol-O-methyltransferase (COMT) Val158Met and brain-derived neurotrophic factor (BDNF) Val66Met. Both COMT and BDNF polymorphisms influenced local oscillation amplitudes and their long-range temporal correlations (LRTCs), while only BDNF polymorphism affected the strength of large-scale synchronization. Our findings demonstrate that COMT and BDNF genetic polymorphisms contribute to inter-individual variability in neuronal oscillation dynamics. Comparison of these results to computational modeling of near-critical synchronization dynamics further suggested that COMT and BDNF polymorphisms influenced local oscillations by modulating the excitation-inhibition balance according to the brain criticality framework.

KW - Biological sciences

KW - Cognitive neuroscience

KW - Neuroscience

UR - http://www.scopus.com/inward/record.url?scp=85137304148&partnerID=8YFLogxK

U2 - 10.1016/j.isci.2022.104985

DO - 10.1016/j.isci.2022.104985

M3 - Journal article

C2 - 36093050

AN - SCOPUS:85137304148

VL - 25

JO - iScience

JF - iScience

SN - 2589-0042

IS - 9

M1 - 104985

ER -