Department of Economics and Business Economics

Genetic identification of cell types underlying brain complex traits yields insights into the etiology of Parkinson's disease

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Standard

Genetic identification of cell types underlying brain complex traits yields insights into the etiology of Parkinson's disease. / Bryois, Julien; Skene, Nathan G; Hansen, Thomas Folkmann; Kogelman, Lisette J A; Watson, Hunna J; Liu, Zijing; Brueggeman, Leo; Breen, Gerome; Bulik, Cynthia M; Arenas, Ernest; Hjerling-Leffler, Jens; Sullivan, Patrick F; Eating Disorders Working Group of the Psychiatric Genomics Consortium.

In: Nature Genetics, Vol. 52, No. 5, 05.2020, p. 482-493.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Harvard

Bryois, J, Skene, NG, Hansen, TF, Kogelman, LJA, Watson, HJ, Liu, Z, Brueggeman, L, Breen, G, Bulik, CM, Arenas, E, Hjerling-Leffler, J, Sullivan, PF & Eating Disorders Working Group of the Psychiatric Genomics Consortium 2020, 'Genetic identification of cell types underlying brain complex traits yields insights into the etiology of Parkinson's disease', Nature Genetics, vol. 52, no. 5, pp. 482-493. https://doi.org/10.1038/s41588-020-0610-9

APA

Bryois, J., Skene, N. G., Hansen, T. F., Kogelman, L. J. A., Watson, H. J., Liu, Z., Brueggeman, L., Breen, G., Bulik, C. M., Arenas, E., Hjerling-Leffler, J., Sullivan, P. F., & Eating Disorders Working Group of the Psychiatric Genomics Consortium (2020). Genetic identification of cell types underlying brain complex traits yields insights into the etiology of Parkinson's disease. Nature Genetics, 52(5), 482-493. https://doi.org/10.1038/s41588-020-0610-9

CBE

Bryois J, Skene NG, Hansen TF, Kogelman LJA, Watson HJ, Liu Z, Brueggeman L, Breen G, Bulik CM, Arenas E, Hjerling-Leffler J, Sullivan PF, Eating Disorders Working Group of the Psychiatric Genomics Consortium. 2020. Genetic identification of cell types underlying brain complex traits yields insights into the etiology of Parkinson's disease. Nature Genetics. 52(5):482-493. https://doi.org/10.1038/s41588-020-0610-9

MLA

Vancouver

Bryois J, Skene NG, Hansen TF, Kogelman LJA, Watson HJ, Liu Z et al. Genetic identification of cell types underlying brain complex traits yields insights into the etiology of Parkinson's disease. Nature Genetics. 2020 May;52(5):482-493. https://doi.org/10.1038/s41588-020-0610-9

Author

Bryois, Julien ; Skene, Nathan G ; Hansen, Thomas Folkmann ; Kogelman, Lisette J A ; Watson, Hunna J ; Liu, Zijing ; Brueggeman, Leo ; Breen, Gerome ; Bulik, Cynthia M ; Arenas, Ernest ; Hjerling-Leffler, Jens ; Sullivan, Patrick F ; Eating Disorders Working Group of the Psychiatric Genomics Consortium. / Genetic identification of cell types underlying brain complex traits yields insights into the etiology of Parkinson's disease. In: Nature Genetics. 2020 ; Vol. 52, No. 5. pp. 482-493.

Bibtex

@article{ccabb2b8160c4b7ba242545c007b0653,
title = "Genetic identification of cell types underlying brain complex traits yields insights into the etiology of Parkinson's disease",
abstract = "Genome-wide association studies have discovered hundreds of loci associated with complex brain disorders, but it remains unclear in which cell types these loci are active. Here we integrate genome-wide association study results with single-cell transcriptomic data from the entire mouse nervous system to systematically identify cell types underlying brain complex traits. We show that psychiatric disorders are predominantly associated with projecting excitatory and inhibitory neurons. Neurological diseases were associated with different cell types, which is consistent with other lines of evidence. Notably, Parkinson's disease was genetically associated not only with cholinergic and monoaminergic neurons (which include dopaminergic neurons) but also with enteric neurons and oligodendrocytes. Using post-mortem brain transcriptomic data, we confirmed alterations in these cells, even at the earliest stages of disease progression. Our study provides an important framework for understanding the cellular basis of complex brain maladies, and reveals an unexpected role of oligodendrocytes in Parkinson's disease.",
author = "Julien Bryois and Skene, {Nathan G} and Hansen, {Thomas Folkmann} and Kogelman, {Lisette J A} and Watson, {Hunna J} and Zijing Liu and Leo Brueggeman and Gerome Breen and Bulik, {Cynthia M} and Ernest Arenas and Jens Hjerling-Leffler and Sullivan, {Patrick F} and {Eating Disorders Working Group of the Psychiatric Genomics Consortium} and Mortensen, {Preben Bo}",
year = "2020",
month = may,
doi = "10.1038/s41588-020-0610-9",
language = "English",
volume = "52",
pages = "482--493",
journal = "Nature Genetics",
issn = "1061-4036",
publisher = "Nature Publishing Group",
number = "5",

}

RIS

TY - JOUR

T1 - Genetic identification of cell types underlying brain complex traits yields insights into the etiology of Parkinson's disease

AU - Bryois, Julien

AU - Skene, Nathan G

AU - Hansen, Thomas Folkmann

AU - Kogelman, Lisette J A

AU - Watson, Hunna J

AU - Liu, Zijing

AU - Brueggeman, Leo

AU - Breen, Gerome

AU - Bulik, Cynthia M

AU - Arenas, Ernest

AU - Hjerling-Leffler, Jens

AU - Sullivan, Patrick F

AU - Eating Disorders Working Group of the Psychiatric Genomics Consortium

AU - Mortensen, Preben Bo

PY - 2020/5

Y1 - 2020/5

N2 - Genome-wide association studies have discovered hundreds of loci associated with complex brain disorders, but it remains unclear in which cell types these loci are active. Here we integrate genome-wide association study results with single-cell transcriptomic data from the entire mouse nervous system to systematically identify cell types underlying brain complex traits. We show that psychiatric disorders are predominantly associated with projecting excitatory and inhibitory neurons. Neurological diseases were associated with different cell types, which is consistent with other lines of evidence. Notably, Parkinson's disease was genetically associated not only with cholinergic and monoaminergic neurons (which include dopaminergic neurons) but also with enteric neurons and oligodendrocytes. Using post-mortem brain transcriptomic data, we confirmed alterations in these cells, even at the earliest stages of disease progression. Our study provides an important framework for understanding the cellular basis of complex brain maladies, and reveals an unexpected role of oligodendrocytes in Parkinson's disease.

AB - Genome-wide association studies have discovered hundreds of loci associated with complex brain disorders, but it remains unclear in which cell types these loci are active. Here we integrate genome-wide association study results with single-cell transcriptomic data from the entire mouse nervous system to systematically identify cell types underlying brain complex traits. We show that psychiatric disorders are predominantly associated with projecting excitatory and inhibitory neurons. Neurological diseases were associated with different cell types, which is consistent with other lines of evidence. Notably, Parkinson's disease was genetically associated not only with cholinergic and monoaminergic neurons (which include dopaminergic neurons) but also with enteric neurons and oligodendrocytes. Using post-mortem brain transcriptomic data, we confirmed alterations in these cells, even at the earliest stages of disease progression. Our study provides an important framework for understanding the cellular basis of complex brain maladies, and reveals an unexpected role of oligodendrocytes in Parkinson's disease.

U2 - 10.1038/s41588-020-0610-9

DO - 10.1038/s41588-020-0610-9

M3 - Journal article

C2 - 32341526

VL - 52

SP - 482

EP - 493

JO - Nature Genetics

JF - Nature Genetics

SN - 1061-4036

IS - 5

ER -