Generation of eight human induced pluripotent stem cell lines from Parkinson's disease patients carrying familial mutations

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We generated eight induced pluripotent stem cell (iPSC) lines from Parkinson's disease (PD) patients with different familial mutations using non-integrating episomal plasmids. All iPSC lines have a normal karyotype, express pluripotent genes including POU5F1, NANOG, and show alkaline phosphatase activity, as well as the ability to differentiate into all three germ layers. These PD iPSC lines can be used for disease modeling to identify PD mechanisms and for the development or stratification of new drugs.
Original languageEnglish
Article number101657
JournalStem Cell Research
Volume42
Number of pages5
ISSN1873-5061
DOIs
Publication statusPublished - 2020

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