Generation of eight human induced pluripotent stem cell lines from Parkinson's disease patients carrying familial mutations

Muwan Chen; Maimaitili Muyesier; Susanne Hvolbøl Buchholdt; Uffe Birk Jensen; Fabia Febbraro; Mark Denham

doi:10.1016/j.scr.2019.101657

Generation of eight human induced pluripotent stem cell lines from Parkinson's disease patients carrying familial mutations

Muwan Chen, Maimaitili Muyesier, Susanne Hvolbøl Buchholdt, Uffe Birk Jensen, Fabia Febbraro, Mark Denham

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

Abstract

We generated eight induced pluripotent stem cell (iPSC) lines from Parkinson's disease (PD) patients with different familial mutations using non-integrating episomal plasmids. All iPSC lines have a normal karyotype, express pluripotent genes including POU5F1, NANOG, and show alkaline phosphatase activity, as well as the ability to differentiate into all three germ layers. These PD iPSC lines can be used for disease modeling to identify PD mechanisms and for the development or stratification of new drugs.

Original language	English
Article number	101657
Journal	Stem Cell Research
Volume	42
Number of pages	5
ISSN	1873-5061
DOIs	https://doi.org/10.1016/j.scr.2019.101657
Publication status	Published - 2020

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title = "Generation of eight human induced pluripotent stem cell lines from Parkinson's disease patients carrying familial mutations",

abstract = "We generated eight induced pluripotent stem cell (iPSC) lines from Parkinson's disease (PD) patients with different familial mutations using non-integrating episomal plasmids. All iPSC lines have a normal karyotype, express pluripotent genes including POU5F1, NANOG, and show alkaline phosphatase activity, as well as the ability to differentiate into all three germ layers. These PD iPSC lines can be used for disease modeling to identify PD mechanisms and for the development or stratification of new drugs.",

author = "Muwan Chen and Maimaitili Muyesier and Buchholdt, {Susanne Hvolb{\o}l} and Jensen, {Uffe Birk} and Fabia Febbraro and Mark Denham",

year = "2020",

doi = "10.1016/j.scr.2019.101657",

language = "English",

volume = "42",

journal = "Stem Cell Research",

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Generation of eight human induced pluripotent stem cell lines from Parkinson's disease patients carrying familial mutations. / Chen, Muwan ; Muyesier, Maimaitili ; Buchholdt, Susanne Hvolbøl et al.
In: Stem Cell Research, Vol. 42, 101657, 2020.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

TY - JOUR

T1 - Generation of eight human induced pluripotent stem cell lines from Parkinson's disease patients carrying familial mutations

AU - Chen, Muwan

AU - Muyesier, Maimaitili

AU - Buchholdt, Susanne Hvolbøl

AU - Jensen, Uffe Birk

AU - Febbraro, Fabia

AU - Denham, Mark

PY - 2020

Y1 - 2020

N2 - We generated eight induced pluripotent stem cell (iPSC) lines from Parkinson's disease (PD) patients with different familial mutations using non-integrating episomal plasmids. All iPSC lines have a normal karyotype, express pluripotent genes including POU5F1, NANOG, and show alkaline phosphatase activity, as well as the ability to differentiate into all three germ layers. These PD iPSC lines can be used for disease modeling to identify PD mechanisms and for the development or stratification of new drugs.

AB - We generated eight induced pluripotent stem cell (iPSC) lines from Parkinson's disease (PD) patients with different familial mutations using non-integrating episomal plasmids. All iPSC lines have a normal karyotype, express pluripotent genes including POU5F1, NANOG, and show alkaline phosphatase activity, as well as the ability to differentiate into all three germ layers. These PD iPSC lines can be used for disease modeling to identify PD mechanisms and for the development or stratification of new drugs.

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U2 - 10.1016/j.scr.2019.101657

DO - 10.1016/j.scr.2019.101657

M3 - Journal article

C2 - 31786474

SN - 1873-5061

VL - 42

JO - Stem Cell Research

JF - Stem Cell Research

M1 - 101657

ER -

Generation of eight human induced pluripotent stem cell lines from Parkinson's disease patients carrying familial mutations

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