Fyn Tyrosine Kinase as Harmonizing Factor in Neuronal Functions and Dysfunctions

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DOI

  • Carmela Matrone, University of Naples Federico II
  • ,
  • Federica Petrillo
  • Rosarita Nasso, University of Naples Federico II
  • ,
  • Gabriella Ferretti, University of Naples Federico II

Fyn is a non-receptor or cytoplasmatic tyrosine kinase (TK) belonging to the Src family kinases (SFKs) involved in multiple transduction pathways in the central nervous system (CNS) including synaptic transmission, myelination, axon guidance, and oligodendrocyte formation. Almost one hundred years after the original description of Fyn, this protein continues to attract extreme interest because of its multiplicity of actions in the molecular signaling pathways underlying neurodevelopmental as well as neuropathologic events. This review highlights and summarizes the most relevant recent findings pertinent to the role that Fyn exerts in the brain, emphasizing aspects related to neurodevelopment and synaptic plasticity. Fyn is a common factor in healthy and diseased brains that targets different proteins and shapes different transduction signals according to the neurological conditions. We will primarily focus on Fyn-mediated signaling pathways involved in neuronal differentiation and plasticity that have been subjected to considerable attention lately, opening the fascinating scenario to target Fyn TK for the development of potential therapeutic interventions for the treatment of CNS injuries and certain neurodegenerative disorders like Alzheimer's disease.

Original languageEnglish
Article number4444
JournalInternational Journal of Molecular Sciences
Volume21
Issue12
ISSN1661-6596
DOIs
Publication statusPublished - Jun 2020

    Research areas

  • Alzheimer’s disease, Fyn tyrosine kinase, neurodegeneration, plexins, semaphorins, synaptic plasticity

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