Fungal NRPS-dependent siderophores: From function to prediction

Jens Laurids Sørensen; Michael Knudsen; Frederik Teilfeldt Hansen; Claus Olesen; Patricia Romans Fuertes; T. Verne Lee; Teis Esben Søndergaard; Christian Nørgaard Storm Pedersen; Ditlev E. Brodersen; Henriette Giese

doi:10.1007/978-1-4939-1191-2_15

Fungal NRPS-dependent siderophores: From function to prediction

Jens Laurids Sørensen, Michael Knudsen, Frederik Teilfeldt Hansen, Claus Olesen, Patricia Romans Fuertes, T. Verne Lee, Teis Esben Søndergaard, Christian Nørgaard Storm Pedersen, Ditlev E. Brodersen, Henriette Giese

Research output: Contribution to book/anthology/report/proceeding › Book chapter › Research › peer-review

Abstract

Iron is an essential, yet often limiting element for the growth of many organisms. In response to iron limitation, fungi have developed siderophores that provide a high-affinity iron uptake system and safe intracellular storage and transport mechanisms to gain a competitive advantage. Here, we discuss the function of siderophores in relation to fungal iron uptake mechanisms and their importance for coexistence with host organisms. The chemical nature of the major groups of siderophores and their regulation is described along with the function and architecture of the large multi-domain enzymes responsible for siderophore synthesis, namely the non-ribosomal peptide synthetases (NRPSs). Finally, we present the most recent advances in our understanding of the structural biology of fungal NRPSs and discuss opportunities for the development of a fungal NRPS prediction server

Original language	English
Title of host publication	Biosynthesis and Molecular Genetics of Fungal Secondary Metabolites
Editors	Juan-Francisco Martin, Carlos Garcia-Estrada, Susanne Zeilinger
Number of pages	13
Publisher	Springer
Publication date	26 Jul 2014
Pages	317-339
Chapter	15
ISBN (Print)	978-1-4939-1190-5
ISBN (Electronic)	978-1-4939-1191-2
DOIs	https://doi.org/10.1007/978-1-4939-1191-2_15
Publication status	Published - 26 Jul 2014

Series	Fungal Biology
ISSN	1878-6146

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10.1007/978-1-4939-1191-2_15

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Sørensen, J. L., Knudsen, M., Hansen, F. T., Olesen, C., Romans Fuertes, P., Lee, T. V., Søndergaard, T. E., Pedersen, C. N. S., Brodersen, D. E., & Giese, H. (2014). Fungal NRPS-dependent siderophores: From function to prediction. In J.-F. Martin, C. Garcia-Estrada, & S. Zeilinger (Eds.), Biosynthesis and Molecular Genetics of Fungal Secondary Metabolites (pp. 317-339). Springer. https://doi.org/10.1007/978-1-4939-1191-2_15

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abstract = "Iron is an essential, yet often limiting element for the growth of many organisms. In response to iron limitation, fungi have developed siderophores that provide a high-affinity iron uptake system and safe intracellular storage and transport mechanisms to gain a competitive advantage. Here, we discuss the function of siderophores in relation to fungal iron uptake mechanisms and their importance for coexistence with host organisms. The chemical nature of the major groups of siderophores and their regulation is described along with the function and architecture of the large multi-domain enzymes responsible for siderophore synthesis, namely the non-ribosomal peptide synthetases (NRPSs). Finally, we present the most recent advances in our understanding of the structural biology of fungal NRPSs and discuss opportunities for the development of a fungal NRPS prediction server",

author = "S{\o}rensen, {Jens Laurids} and Michael Knudsen and Hansen, {Frederik Teilfeldt} and Claus Olesen and {Romans Fuertes}, Patricia and Lee, {T. Verne} and S{\o}ndergaard, {Teis Esben} and Pedersen, {Christian N{\o}rgaard Storm} and Brodersen, {Ditlev E.} and Henriette Giese",

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Sørensen, JL, Knudsen, M, Hansen, FT, Olesen, C, Romans Fuertes, P, Lee, TV, Søndergaard, TE, Pedersen, CNS , Brodersen, DE & Giese, H 2014, Fungal NRPS-dependent siderophores: From function to prediction. in J-F Martin, C Garcia-Estrada & S Zeilinger (eds), Biosynthesis and Molecular Genetics of Fungal Secondary Metabolites. Springer, Fungal Biology, pp. 317-339. https://doi.org/10.1007/978-1-4939-1191-2_15

Fungal NRPS-dependent siderophores: From function to prediction. / Sørensen, Jens Laurids; Knudsen, Michael; Hansen, Frederik Teilfeldt et al.
Biosynthesis and Molecular Genetics of Fungal Secondary Metabolites. ed. / Juan-Francisco Martin; Carlos Garcia-Estrada; Susanne Zeilinger. Springer, 2014. p. 317-339 (Fungal Biology).

Research output: Contribution to book/anthology/report/proceeding › Book chapter › Research › peer-review

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AU - Sørensen, Jens Laurids

AU - Knudsen, Michael

AU - Hansen, Frederik Teilfeldt

AU - Olesen, Claus

AU - Romans Fuertes, Patricia

AU - Lee, T. Verne

AU - Søndergaard, Teis Esben

AU - Pedersen, Christian Nørgaard Storm

AU - Brodersen, Ditlev E.

AU - Giese, Henriette

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N2 - Iron is an essential, yet often limiting element for the growth of many organisms. In response to iron limitation, fungi have developed siderophores that provide a high-affinity iron uptake system and safe intracellular storage and transport mechanisms to gain a competitive advantage. Here, we discuss the function of siderophores in relation to fungal iron uptake mechanisms and their importance for coexistence with host organisms. The chemical nature of the major groups of siderophores and their regulation is described along with the function and architecture of the large multi-domain enzymes responsible for siderophore synthesis, namely the non-ribosomal peptide synthetases (NRPSs). Finally, we present the most recent advances in our understanding of the structural biology of fungal NRPSs and discuss opportunities for the development of a fungal NRPS prediction server

AB - Iron is an essential, yet often limiting element for the growth of many organisms. In response to iron limitation, fungi have developed siderophores that provide a high-affinity iron uptake system and safe intracellular storage and transport mechanisms to gain a competitive advantage. Here, we discuss the function of siderophores in relation to fungal iron uptake mechanisms and their importance for coexistence with host organisms. The chemical nature of the major groups of siderophores and their regulation is described along with the function and architecture of the large multi-domain enzymes responsible for siderophore synthesis, namely the non-ribosomal peptide synthetases (NRPSs). Finally, we present the most recent advances in our understanding of the structural biology of fungal NRPSs and discuss opportunities for the development of a fungal NRPS prediction server

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DO - 10.1007/978-1-4939-1191-2_15

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BT - Biosynthesis and Molecular Genetics of Fungal Secondary Metabolites

A2 - Martin, Juan-Francisco

A2 - Garcia-Estrada, Carlos

A2 - Zeilinger, Susanne

PB - Springer

ER -

Fungal NRPS-dependent siderophores: From function to prediction

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