Functional Prototissues Using Artificial Cells as Building Blocks and Their Biomedical Applications

Xiangxiang Zhang; Chao Li; Boyu Yang; Weichen Wang; Jingjing Zhao; Wan Zhao; Mingdong Dong; Xiaojun Han

doi:10.1002/adfm.202405823

Functional Prototissues Using Artificial Cells as Building Blocks and Their Biomedical Applications

Xiangxiang Zhang, Chao Li^*, Boyu Yang, Weichen Wang, Jingjing Zhao, Wan Zhao, Mingdong Dong^*, Xiaojun Han^*

^*Corresponding author for this work

Interdisciplinary Nanoscience Center

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Review › Research › peer-review

Abstract

The construction of living systems from the bottom-up helps to explore the complex processes of life and to understand their working mechanism. Prototissues, constructed using artificial cells as building blocks, mimic life systems at a high-order tissue level, whilst artificial cells usually mimic living cells at the individual cell level. The 3D biomimetic prototissues demonstrate exceptional performances and collective functions, which reveal the working mechanisms of living tissues and hold promising potential for biomedical applications. This review systematically summarized the research progress of the field of prototissues. The engineering methods for fabricating two types of prototissues are introduced first, followed by the functions of prototissues including collective behaviors and signal communications, as well as their biomedical applications. The challenges and future trends are proposed at the end of the paper.

Original language	English
Article number	2405823
Journal	Advanced Functional Materials
Volume	34
Issue	40
ISSN	1616-301X
DOIs	https://doi.org/10.1002/adfm.202405823
Publication status	Published - 1 Oct 2024

Keywords

artificial cell
collective behavior
prototissue
signal communication

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10.1002/adfm.202405823

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title = "Functional Prototissues Using Artificial Cells as Building Blocks and Their Biomedical Applications",

abstract = "The construction of living systems from the bottom-up helps to explore the complex processes of life and to understand their working mechanism. Prototissues, constructed using artificial cells as building blocks, mimic life systems at a high-order tissue level, whilst artificial cells usually mimic living cells at the individual cell level. The 3D biomimetic prototissues demonstrate exceptional performances and collective functions, which reveal the working mechanisms of living tissues and hold promising potential for biomedical applications. This review systematically summarized the research progress of the field of prototissues. The engineering methods for fabricating two types of prototissues are introduced first, followed by the functions of prototissues including collective behaviors and signal communications, as well as their biomedical applications. The challenges and future trends are proposed at the end of the paper.",

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T1 - Functional Prototissues Using Artificial Cells as Building Blocks and Their Biomedical Applications

AU - Zhang, Xiangxiang

AU - Li, Chao

AU - Yang, Boyu

AU - Wang, Weichen

AU - Zhao, Jingjing

AU - Zhao, Wan

AU - Dong, Mingdong

AU - Han, Xiaojun

PY - 2024/10/1

Y1 - 2024/10/1

N2 - The construction of living systems from the bottom-up helps to explore the complex processes of life and to understand their working mechanism. Prototissues, constructed using artificial cells as building blocks, mimic life systems at a high-order tissue level, whilst artificial cells usually mimic living cells at the individual cell level. The 3D biomimetic prototissues demonstrate exceptional performances and collective functions, which reveal the working mechanisms of living tissues and hold promising potential for biomedical applications. This review systematically summarized the research progress of the field of prototissues. The engineering methods for fabricating two types of prototissues are introduced first, followed by the functions of prototissues including collective behaviors and signal communications, as well as their biomedical applications. The challenges and future trends are proposed at the end of the paper.

AB - The construction of living systems from the bottom-up helps to explore the complex processes of life and to understand their working mechanism. Prototissues, constructed using artificial cells as building blocks, mimic life systems at a high-order tissue level, whilst artificial cells usually mimic living cells at the individual cell level. The 3D biomimetic prototissues demonstrate exceptional performances and collective functions, which reveal the working mechanisms of living tissues and hold promising potential for biomedical applications. This review systematically summarized the research progress of the field of prototissues. The engineering methods for fabricating two types of prototissues are introduced first, followed by the functions of prototissues including collective behaviors and signal communications, as well as their biomedical applications. The challenges and future trends are proposed at the end of the paper.

KW - artificial cell

KW - collective behavior

KW - prototissue

KW - signal communication

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U2 - 10.1002/adfm.202405823

DO - 10.1002/adfm.202405823

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JO - Advanced Functional Materials

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Functional Prototissues Using Artificial Cells as Building Blocks and Their Biomedical Applications

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Keywords

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