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Functional harmonics reveal multi-dimensional basis functions underlying cortical organization

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  • Katharina Glomb, University of Lausanne
  • ,
  • Morten L. Kringelbach
  • Gustavo Deco, Pompeu Fabra University, ICREA, Max Planck Institute for Human Cognitive and Brain Sciences, Monash University
  • ,
  • Patric Hagmann, University of Lausanne
  • ,
  • Joel Pearson, University of New South Wales
  • ,
  • Selen Atasoy, University of Oxford

The human brain consists of specialized areas that flexibly interact to form a multitude of functional networks. Complementary to this notion of modular organization, brain function has been shown to vary along a smooth continuum across the whole cortex. We demonstrate a mathematical framework that accounts for both of these perspectives: harmonic modes. We calculate the harmonic modes of the brain's functional connectivity graph, called “functional harmonics,” revealing a multi-dimensional, frequency-ordered set of basis functions. Functional harmonics link characteristics of cortical organization across several spatial scales, capturing aspects of intra-areal organizational features (retinotopy, somatotopy), delineating brain areas, and explaining macroscopic functional networks as well as global cortical gradients. Furthermore, we show how the activity patterns elicited by seven different tasks are reconstructed from a very small subset of functional harmonics. Our results suggest that the principle of harmonicity, ubiquitous in nature, also underlies functional cortical organization in the human brain.

Original languageEnglish
Article number109554
JournalCell Reports
Volume36
Issue8
Number of pages21
ISSN2211-1247
DOIs
Publication statusPublished - Aug 2021

Bibliographical note

Publisher Copyright:
© 2021 The Author(s)

    Research areas

  • brain networks, fMRI, functional connectivity, harmonic modes, human cortex

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