Functional assessment of hepatobiliary secretion by 11C-cholylsarcosine positron emission tomography

Nikolaj Ørntoft; Kim Frisch; Peter Ott; Susanne Keiding; Michael Sørensen

doi:10.1016/j.bbadis.2017.11.016

Functional assessment of hepatobiliary secretion by 11C-cholylsarcosine positron emission tomography

Nikolaj Ørntoft, Kim Frisch, Peter Ott, Susanne Keiding, Michael Sørensen

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Review › Research › peer-review

9 Citations (Scopus)

Abstract

Positron emission tomography (PET) with 11C-cholylsarcosine (11C-CSar), a radiolabelled synthetic N-methylglycine (sarcosine) conjugate of cholic acid, is a novel molecular imaging technique that enables quantitative assessment of the individual transport steps involved in hepatic secretion of conjugated bile acids. Here, we present the method and discuss its potential clinical and scientific applications based on findings in the first human study of healthy subjects and patients with cholestasis. We also present a clinical example of a patient studied during and six months after an episode of drug-induced cholestatic liver injury.

Original language	English
Journal	B B A - Molecular Basis of Disease
Volume	1864
Issue	4, Part B
Pages (from-to)	1240-1244
Number of pages	5
ISSN	0925-4439
DOIs	https://doi.org/10.1016/j.bbadis.2017.11.016
Publication status	Published - Apr 2018

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Journal Article
Review

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10.1016/j.bbadis.2017.11.016

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abstract = "Positron emission tomography (PET) with 11C-cholylsarcosine (11C-CSar), a radiolabelled synthetic N-methylglycine (sarcosine) conjugate of cholic acid, is a novel molecular imaging technique that enables quantitative assessment of the individual transport steps involved in hepatic secretion of conjugated bile acids. Here, we present the method and discuss its potential clinical and scientific applications based on findings in the first human study of healthy subjects and patients with cholestasis. We also present a clinical example of a patient studied during and six months after an episode of drug-induced cholestatic liver injury.",

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Functional assessment of hepatobiliary secretion by 11C-cholylsarcosine positron emission tomography. / Ørntoft, Nikolaj; Frisch, Kim ; Ott, Peter et al.
In: B B A - Molecular Basis of Disease, Vol. 1864, No. 4, Part B, 04.2018, p. 1240-1244.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Review › Research › peer-review

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T1 - Functional assessment of hepatobiliary secretion by 11C-cholylsarcosine positron emission tomography

AU - Ørntoft, Nikolaj

AU - Frisch, Kim

AU - Ott, Peter

AU - Keiding, Susanne

AU - Sørensen, Michael

PY - 2018/4

Y1 - 2018/4

N2 - Positron emission tomography (PET) with 11C-cholylsarcosine (11C-CSar), a radiolabelled synthetic N-methylglycine (sarcosine) conjugate of cholic acid, is a novel molecular imaging technique that enables quantitative assessment of the individual transport steps involved in hepatic secretion of conjugated bile acids. Here, we present the method and discuss its potential clinical and scientific applications based on findings in the first human study of healthy subjects and patients with cholestasis. We also present a clinical example of a patient studied during and six months after an episode of drug-induced cholestatic liver injury.

AB - Positron emission tomography (PET) with 11C-cholylsarcosine (11C-CSar), a radiolabelled synthetic N-methylglycine (sarcosine) conjugate of cholic acid, is a novel molecular imaging technique that enables quantitative assessment of the individual transport steps involved in hepatic secretion of conjugated bile acids. Here, we present the method and discuss its potential clinical and scientific applications based on findings in the first human study of healthy subjects and patients with cholestasis. We also present a clinical example of a patient studied during and six months after an episode of drug-induced cholestatic liver injury.

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KW - Review

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DO - 10.1016/j.bbadis.2017.11.016

M3 - Review

C2 - 29197661

SN - 0925-4439

VL - 1864

SP - 1240

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JO - B B A - Molecular Basis of Disease

JF - B B A - Molecular Basis of Disease

IS - 4, Part B

ER -

Functional assessment of hepatobiliary secretion by 11C-cholylsarcosine positron emission tomography

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