Functional and Structural Changes of the Blood-Nerve-Barrier in Diabetic Neuropathy

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperReviewResearchpeer-review

DOI

The incidence of diabetes mellitus is approaching global epidemic proportions and should be considered a major health-care problem of modern societies in the twenty-first century. Diabetic neuropathy is a common chronic complication of diabetes and, although an adequate glycemic control can reduce the frequency of diabetic neuropathy in type 1 diabetes, the majority of type 2 diabetic patients will develop this complication. The underlying cellular and molecular mechanisms are still poorly understood, preventing the development of effective treatment strategies. However, accumulating evidence suggests that breakdown of the blood-nerve barrier (BNB) plays a pivotal pathophysiological role in diabetic neuropathy. In the present review, we highlight the structural and functional significance of the BNB in health and disease, focusing on the pathological molecular events leading to BNB dysfunction in diabetic neuropathy. In addition, we discuss potential molecular targets involved in BNB homeostasis that may pave the way toward novel therapeutic strategies for treating diabetic neuropathy.

Original languageEnglish
Article number1038
JournalFrontiers in Neuroscience
Volume12
Number of pages9
ISSN1662-4548
DOIs
Publication statusPublished - 1 Jan 2019

    Research areas

  • Blood-nerve barrier, Diabetes, Diabetic neuropathy, Microvascular liabilities, Peripheral nerve

See relations at Aarhus University Citationformats

ID: 142884290