Functional Amyloids: The Biomaterials of Tomorrow?

Samuel Peña-Díaz, William Pallisgaard Olsen, Huabing Wang, Daniel E Otzen

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review


Functional amyloid (FAs), particularly the bacterial proteins CsgA and FapC, have many useful properties as biomaterials: high stability, efficient, and controllable formation of a single type of amyloid, easy availability as extracellular material in bacterial biofilm and flexible engineering to introduce new properties. CsgA in particular has already demonstrated its worth in hydrogels for stable gastrointestinal colonization and regenerative tissue engineering, cell-specific drug release, water-purification filters, and different biosensors. It also holds promise as catalytic amyloid; existing weak and unspecific activity can undoubtedly be improved by targeted engineering and benefit from the repetitive display of active sites on a surface. Unfortunately, FapC remains largely unexplored and no application is described so far. Since FapC shares many common features with CsgA, this opens the window to its development as a functional scaffold. The multiple imperfect repeats in CsgA and FapC form a platform to introduce novel properties, e.g., in connecting linkers of variable lengths. While exploitation of this potential is still at an early stage, particularly for FapC, a thorough understanding of their molecular properties will pave the way for multifunctional fibrils which can contribute toward solving many different societal challenges, ranging from CO 2 fixation to hydrolysis of plastic nanoparticles.

Original languageEnglish
Article number2312823
JournalAdvanced Materials
Publication statusPublished - 2 May 2024


  • bacterial amyloid
  • bioplastic
  • biosensors
  • catalytic amyloid
  • hydrogels


Dive into the research topics of 'Functional Amyloids: The Biomaterials of Tomorrow?'. Together they form a unique fingerprint.

Cite this