Frontal cortex dysfunction as a target for remediation in opiate use disorder: Role in cognitive dysfunction and disordered reward systems

Research output: Contribution to book/anthology/report/proceedingBook chapterResearchpeer-review

  • Dominic Roberts, Montclair State University
  • ,
  • Andrew Wolfarth, Montclair State University
  • ,
  • Connie Sanchez
  • Alan L. Pehrson, Montclair State University

In this chapter, we develop a model of μ- and δ-opioid receptor (OR) effects on cellular activity in the corticostriatal circuit after reviewing clinical data on cognitive and mood impairments in opioid substance use disorder (OUD), we use this model to derive information on the relevance of opioid actions in this circuit for cognition and reward. We find that the cognitive impairments and rewarding properties of acute μ-OR activation can reasonably explained by pharmacological actions in the corticostriatal circuit. However, long-term cognitive impairments and mood dysfunction observed in OUD are probably induced by opiate abuse-related degenerative mechanisms.

Original languageEnglish
Title of host publicationThe Opioid System as the Interface between the Brain’s Cognitive and Motivational Systems
EditorsShane O'Mara
Number of pages49
Volume239
PublisherElsevier
Publication year2018
Pages179-227
Chapter5
ISBN (print)9780444641670
DOIs
Publication statusPublished - 2018
SeriesProgress in Brain Research
Volume239
ISSN0079-6123

    Research areas

  • Cognition, Frontal cortex, Mood, Nucleus accumbens, Opioid substance use disorder, δ-Opioid receptor, μ-Opioid receptor, Cognitive Dysfunction/physiopathology, Humans, Cognition/drug effects, Opioid-Related Disorders/physiopathology, Reward, Frontal Lobe/drug effects, Analgesics, Opioid/pharmacology

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ID: 150102470