From Single-Compartment Artificial Cells to Tissue-Like Materials

Isabella Nymann Westensee; Paula De Dios Andres; Brigitte Maria Stadler

doi:10.1002/admt.202301804

From Single-Compartment Artificial Cells to Tissue-Like Materials

Isabella Nymann Westensee, Paula De Dios Andres, Brigitte Maria Stadler^*

^*Corresponding author for this work

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Review › Research › peer-review

5 Citations (Scopus)

Abstract

Designing and assembling artificial cells (ACs) is a core direction in bottom-up synthetic biology. Here, the advancements in the past 3 years in engineering ACs with focus on compartmentalization and surface modifications with the aim for their integration in semi-synthetic tissue are outlined. Compartmentalization in vesicles, coacervates and hydrogels are discussed for encapsulated catalysis or cytoskeleton formation including the use of components of mammalian cells to increase the ACs’ complexity. Following on, the surface modification of the ACs is reviewed due to its relevance when integration of ACs with mammalian cells into semi-synthetic tissue is the goal. Finally, the interaction of ACs and mammalian cells for cellular communication or the fabrication of semi-synthetic tissue toward therapeutic opportunities is outlined, before a short perspective is provided.

Original language	English
Article number	2301804
Journal	Advanced Materials Technologies
Volume	9
Issue	18
ISSN	2365-709X
DOIs	https://doi.org/10.1002/admt.202301804
Publication status	Published - 18 Sept 2024

Keywords

artificial cells
cellular communication
compartmentalization
integration
tissue engineering

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10.1002/admt.202301804Licence: CC BY

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title = "From Single-Compartment Artificial Cells to Tissue-Like Materials",

abstract = "Designing and assembling artificial cells (ACs) is a core direction in bottom-up synthetic biology. Here, the advancements in the past 3 years in engineering ACs with focus on compartmentalization and surface modifications with the aim for their integration in semi-synthetic tissue are outlined. Compartmentalization in vesicles, coacervates and hydrogels are discussed for encapsulated catalysis or cytoskeleton formation including the use of components of mammalian cells to increase the ACs{\textquoteright} complexity. Following on, the surface modification of the ACs is reviewed due to its relevance when integration of ACs with mammalian cells into semi-synthetic tissue is the goal. Finally, the interaction of ACs and mammalian cells for cellular communication or the fabrication of semi-synthetic tissue toward therapeutic opportunities is outlined, before a short perspective is provided.",

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From Single-Compartment Artificial Cells to Tissue-Like Materials

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