Formation of i-motifs from acyclic (l)-threoninol nucleic acids

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

DOI

Acyclic (l)-threoninol nucleic acids ((l)-aTNA) containing poly-cytosines are prepared and investigated at various pH values, revealing the formation of a highly stable structure at lower pH that have the characteristics of an i-motif. Depending on the sequence, the aTNA forms inter-, bi- and intra-molecular i-motif structures. Pyrene was conjugated to aTNA sequences and both monomeric and excimer fluorescence were efficiently quenched by the i-motif structures and thus demonstrated that the aTNA i-motif can serve as a pH switch.

Original languageEnglish
JournalOrganic & Biomolecular Chemistry
Volume17
Issue33
Pages (from-to)7655-7659
Number of pages5
ISSN1477-0520
DOIs
Publication statusPublished - Sep 2019

    Research areas

  • FLUORESCENT-PROBE, DNA, OLIGONUCLEOTIDES, DUPLEX

See relations at Aarhus University Citationformats

ID: 168074816