Formation of Hypoxanthine Tetrad by Reaction with Sodium Chloride: From Planar to Stereo

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

DOI

  • Chong Chen, Harbin Inst Technol, Harbin Institute of Technology, Sch Chem & Chem Engn, MIIT Key Lab Crit Mat Technol New Energy Convers, State Key Lab Urban Water Resource & Environm
  • ,
  • Pengcheng Ding, Harbin Inst Technol, Harbin Institute of Technology, Condensed Matter Sci & Technol Inst
  • ,
  • Manuela Mura, Univ Lincoln, University of Lincoln, Sch Math & Phys
  • ,
  • Yanghan Chen, Harbin Inst Technol, Harbin Institute of Technology, Condensed Matter Sci & Technol Inst
  • ,
  • Ye Sun, Harbin Inst Technol, Harbin Institute of Technology, Condensed Matter Sci & Technol Inst
  • ,
  • Lev N. Kantorovich, Kings Coll London, Kings College London, University of London, Phys Dept, Strand
  • ,
  • Henkjan Gersen, Univ Bristol, University of Bristol, HH Wills Phys Lab
  • ,
  • Flemming Besenbacher
  • Miao Yu, Harbin Inst Technol, Harbin Institute of Technology, Sch Chem & Chem Engn, MIIT Key Lab Crit Mat Technol New Energy Convers, State Key Lab Urban Water Resource & Environm

By reacting with NaCl on Au(111), the formation of hypoxanthine (HX) tetrads is demonstrated at the atomic scale in real space. These results directly demonstrate that alternative purine tetrads can be formed in both planar and non-planar configuration, and that ionic bonding plays a crucial role for the formation and planar-to-stereo transformation of the tetrads, providing deeper insight for constructing artificial DNA/RNA quadruplexes. Moreover, both the tilted HXs and Na show strong charge transfer with the substrate in the non-planar phase. The insights gained by this work also open up new routes to tune the electrostatic nature of metal-organic interfaces and design stereo-nanostructures on surfaces.

Original languageEnglish
JournalAngewandte Chemie International Edition
Volume57
Issue49
Pages (from-to)16015-16019
Number of pages5
ISSN1433-7851
DOIs
Publication statusPublished - 3 Dec 2018

    Research areas

  • adlayer-substrate charge transfer, hypoxanthine, ionic bonding, non-planarity, tetrads, G-QUADRUPLEXES, ELECTRONIC-STRUCTURE, CRYSTAL-STRUCTURE, INOSINE TETRAD, DNA, NETWORKS, XANTHINE, QUARTETS, LAYERS

See relations at Aarhus University Citationformats

ID: 139016396