The performance and reliability of Cyber-Physical Systems are increasingly aided through the use of digital twins, which mirror the static and dynamic behaviour of a Cyber-Physical System (CPS) in software. Digital twins enable the development of self-adaptive CPSs which reconfigure their behaviour in response to novel environments. It is crucial that these self-adaptations are formally verified at runtime, to avoid expensive re-certification of the reconfigured CPS. In this paper, we demonstrate formally verified self-adaptation in a digital twinning system, by constructing a non-deterministic model which captures the uncertainties in the system behaviour after a self-adaptation. We use Signal Temporal Logic to specify the safety requirements the system must satisfy after reconfiguration and employ formal methods based on verified monitoring over Flow* flowpipes to check these properties at runtime. This gives us a framework to predictively detect and mitigate unsafe self-adaptations before they can lead to unsafe states in the physical system.