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Follicular Dendritic Cells Modulate Germinal Center B Cell Diversity through FcγRIIB
Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
DOI
- https://doi.org/10.1016/j.celrep.2019.10.086
Final published version
- Cees E. van der Poel, Boston Children's Hospital ,
- Goran Bajic, Boston Children's Hospital ,
- Charles W. Macaulay, Boston Children's Hospital, Boston University ,
- Theo van den Broek, Boston Children's Hospital ,
- Christian D. Ellson, GlaxoSmithKline ,
- Gerben Bouma, GlaxoSmithKline ,
- Gabriel D. Victora, Rockefeller University ,
- Søren E. Degn
- Michael C. Carroll, Boston Children's Hospital
van der Poel et al. show that follicular dendritic cells (FDCs) can regulate germinal center diversity through FcγRIIB. In the absence of this receptor, germinal centers appear more diverse. In addition, the loss of FcγRIIB on FDCs leads to the persistence of IgM clones with decreased levels of somatic hypermutation.
| Original language | English |
|---|---|
| Journal | Cell Reports |
| Volume | 29 |
| Issue | 9 |
| Pages (from-to) | 2745-2755.e4 |
| Number of pages | 11 |
| ISSN | 2211-1247 |
| DOIs | |
| Publication status | Published - 2019 |
- autoimmunity, CD32, clonal selection, FcγRIIB, follicular dendritic cells, germinal center
Research areas
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ID: 173205875