Follicular Dendritic Cells Modulate Germinal Center B Cell Diversity through FcγRIIB

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  • Cees E. van der Poel, Boston Children's Hospital
  • ,
  • Goran Bajic, Boston Children's Hospital
  • ,
  • Charles W. Macaulay, Boston Children's Hospital, Boston University
  • ,
  • Theo van den Broek, Boston Children's Hospital
  • ,
  • Christian D. Ellson, GlaxoSmithKline
  • ,
  • Gerben Bouma, GlaxoSmithKline
  • ,
  • Gabriel D. Victora, Rockefeller University
  • ,
  • Søren E. Degn
  • Michael C. Carroll, Boston Children's Hospital

van der Poel et al. show that follicular dendritic cells (FDCs) can regulate germinal center diversity through FcγRIIB. In the absence of this receptor, germinal centers appear more diverse. In addition, the loss of FcγRIIB on FDCs leads to the persistence of IgM clones with decreased levels of somatic hypermutation.

Original languageEnglish
JournalCell Reports
Volume29
Issue9
Pages (from-to)2745-2755.e4
Number of pages11
ISSN2211-1247
DOIs
Publication statusPublished - 2019

    Research areas

  • autoimmunity, CD32, clonal selection, FcγRIIB, follicular dendritic cells, germinal center

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