Follicular Dendritic Cells Modulate Germinal Center B Cell Diversity through FcγRIIB

Cees E. van der Poel; Goran Bajic; Charles W. Macaulay; Theo van den Broek; Christian D. Ellson; Gerben Bouma; Gabriel D. Victora; Søren E. Degn; Michael C. Carroll

doi:10.1016/j.celrep.2019.10.086

Follicular Dendritic Cells Modulate Germinal Center B Cell Diversity through FcγRIIB

Cees E. van der Poel, Goran Bajic, Charles W. Macaulay, Theo van den Broek, Christian D. Ellson, Gerben Bouma, Gabriel D. Victora, Søren E. Degn, Michael C. Carroll^*

^*Corresponding author for this work

Department of Biomedicine - Forskning og uddannelse, Skou-bygningen

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

28 Citations (Scopus)

Abstract

van der Poel et al. show that follicular dendritic cells (FDCs) can regulate germinal center diversity through FcγRIIB. In the absence of this receptor, germinal centers appear more diverse. In addition, the loss of FcγRIIB on FDCs leads to the persistence of IgM clones with decreased levels of somatic hypermutation.

Original language	English
Journal	Cell Reports
Volume	29
Issue	9
Pages (from-to)	2745-2755.e4
Number of pages	11
ISSN	2211-1247
DOIs	https://doi.org/10.1016/j.celrep.2019.10.086
Publication status	Published - 2019

Keywords

autoimmunity
CD32
clonal selection
FcγRIIB
follicular dendritic cells
germinal center

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10.1016/j.celrep.2019.10.086Licence: CC BY-NC-ND

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@article{65ed27a9dae94e8884d0b74e74b49558,

title = "Follicular Dendritic Cells Modulate Germinal Center B Cell Diversity through FcγRIIB",

abstract = "van der Poel et al. show that follicular dendritic cells (FDCs) can regulate germinal center diversity through FcγRIIB. In the absence of this receptor, germinal centers appear more diverse. In addition, the loss of FcγRIIB on FDCs leads to the persistence of IgM clones with decreased levels of somatic hypermutation.",

keywords = "autoimmunity, CD32, clonal selection, FcγRIIB, follicular dendritic cells, germinal center",

author = "{van der Poel}, {Cees E.} and Goran Bajic and Macaulay, {Charles W.} and {van den Broek}, Theo and Ellson, {Christian D.} and Gerben Bouma and Victora, {Gabriel D.} and Degn, {S{\o}ren E.} and Carroll, {Michael C.}",

year = "2019",

doi = "10.1016/j.celrep.2019.10.086",

language = "English",

volume = "29",

pages = "2745--2755.e4",

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T1 - Follicular Dendritic Cells Modulate Germinal Center B Cell Diversity through FcγRIIB

AU - van der Poel, Cees E.

AU - Bajic, Goran

AU - Macaulay, Charles W.

AU - van den Broek, Theo

AU - Ellson, Christian D.

AU - Bouma, Gerben

AU - Victora, Gabriel D.

AU - Degn, Søren E.

AU - Carroll, Michael C.

PY - 2019

Y1 - 2019

N2 - van der Poel et al. show that follicular dendritic cells (FDCs) can regulate germinal center diversity through FcγRIIB. In the absence of this receptor, germinal centers appear more diverse. In addition, the loss of FcγRIIB on FDCs leads to the persistence of IgM clones with decreased levels of somatic hypermutation.

AB - van der Poel et al. show that follicular dendritic cells (FDCs) can regulate germinal center diversity through FcγRIIB. In the absence of this receptor, germinal centers appear more diverse. In addition, the loss of FcγRIIB on FDCs leads to the persistence of IgM clones with decreased levels of somatic hypermutation.

KW - autoimmunity

KW - CD32

KW - clonal selection

KW - FcγRIIB

KW - follicular dendritic cells

KW - germinal center

UR - http://www.scopus.com/inward/record.url?scp=85075471163&partnerID=8YFLogxK

U2 - 10.1016/j.celrep.2019.10.086

DO - 10.1016/j.celrep.2019.10.086

M3 - Journal article

C2 - 31775042

AN - SCOPUS:85075471163

SN - 2211-1247

VL - 29

SP - 2745-2755.e4

JO - Cell Reports

JF - Cell Reports

IS - 9

ER -

Follicular Dendritic Cells Modulate Germinal Center B Cell Diversity through FcγRIIB

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Keywords

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