Fluctuation-dissipation theorem and the discovery of distinctive off-equilibrium signatures of brain states

Juan Manuel Monti; Yonatan Sanz Perl; Enzo Tagliazucchi; Morten L. Kringelbach; Gustavo Deco

doi:10.1103/PhysRevResearch.7.013301

Fluctuation-dissipation theorem and the discovery of distinctive off-equilibrium signatures of brain states

Juan Manuel Monti^*, Yonatan Sanz Perl, Enzo Tagliazucchi, Morten L. Kringelbach, Gustavo Deco

^*Corresponding author for this work

Department of Clinical Medicine - Center for Music In the Brain

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Abstract

The brain is able to sustain many different states as shown by the daily natural transitions between wakefulness and sleep. Yet, the underlying complex dynamics of these brain states are essentially in nonequilibrium. Here, we develop a thermodynamical formalism based on the off-equilibrium extension of the fluctuation-dissipation theorem (FDT) together with a whole-brain model. This allows us to investigate the nonequilibrium dynamics of different brain states and more specifically to apply this formalism to wakefulness and deep sleep brain states. We show that the off-equilibrium thermodynamical signatures of brain states are significantly different in terms of the overall level of differential and integral violation of FDT. Furthermore, the framework allows for a detailed understanding of how different brain regions and networks are contributing to the off-equilibrium signatures in different brain states. Overall, this framework shows great promise for characterizing and differentiating brain states in health and disease.

Original language	English
Article number	013301
Journal	Physical Review Research
Volume	7
Issue	1
ISSN	2643-1564
DOIs	https://doi.org/10.1103/PhysRevResearch.7.013301
Publication status	Published - Jan 2025

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Fluctuation-dissipation theorem and the discovery of distinctive off-equilibrium signatures of brain states. / Monti, Juan Manuel; Perl, Yonatan Sanz; Tagliazucchi, Enzo et al.
In: Physical Review Research , Vol. 7, No. 1, 013301, 01.2025.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

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AU - Deco, Gustavo

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Fluctuation-dissipation theorem and the discovery of distinctive off-equilibrium signatures of brain states

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